And1-IN-1
Based on 1 Customer Validation
And1-IN-1 is a potent And1 inhibitor with an IC50 of 2.08 μM. And1-IN-1 binds to the N-terminus of And-1 and induces a conformational change in And-1, which promotes the interaction of And-1 with E3 ligase CUL4B for ubiquitin-mediated degradation. And1-IN-1 suppresses the growth of a broad range of cancers and resensitizes platinum-resistant ovarian cancer cells to platinum agents. And1-IN-1 can be used for the studies of ovarian cancer and breast cancer.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 2451028-69-4
- Formula: C15H11BCl2O2
- Molecular Weight:304.96
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All DNA/RNA Synthesis Isoforms
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Biological Activity
And1[1]
And1-IN-1 (Compound CH3) (5 μM, 48 h) induces And-1 degradation via the CUL4B-mediated proteasome degradation pathway in IGROV1 cells[1].
And1-IN-1 (0.01-100 μM) demonstrates potent anti-proliferative effects across the NCI-60 cancer cell line panel (particularly sensitive to renal cancer, leukemia, and CNS tumors), achieving an average growth inhibition rate of 98.16% at 10 μM[1].
And1-IN-1 (1 μM) displays great synergy with Cisplatin (HY-17394) to reduce the clonogenic capacity of IGROV1 CR cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IGROV1 cells
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Concentration:5 μM
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Incubation Time:48 h
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Result:Reduced And-1 protein levels, and reduced And-1 levels were restored by MG132 (HY-13259) treatment.
Increased the interaction between FLAG-And-1 and CUL4B.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ovarian cancer (IGROV1) and breast Cancer (MCF7) xenograft model established in female nude mice[1]
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Dosage:20 and 40 mg/kg
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Administration:Intraperitoneal injection (i.p.), every 3 days for 3 weeks
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Result:Reduced tumor volume by 67% (IGROV1) and 59% (MCF7) at 40 mg/kg.
Reduced tumor volume by ~82% in cisplatin-resistant IGROV1 CR tumors with Cisplatin.
Reduced And-1 protein levels and increased cleaved caspase-3 in tumors.
Chemical Information
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CAS No. 2451028-69-4
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Appearance Solid
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Molecular Weight 304.96
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Formula C15H11BCl2O2
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Color White to off-white
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SMILES
OB1OCC2=CC(/C=C/C3=CC=C(Cl)C(Cl)=C3)=CC=C21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 120 mg/mL (393.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2791 mL | 16.3956 mL | 32.7912 mL | 81.9780 mL |
| 5 mM | 0.6558 mL | 3.2791 mL | 6.5582 mL | 16.3956 mL | |
| 10 mM | 0.3279 mL | 1.6396 mL | 3.2791 mL | 8.1978 mL | |
| 15 mM | 0.2186 mL | 1.0930 mL | 2.1861 mL | 5.4652 mL | |
| 20 mM | 0.1640 mL | 0.8198 mL | 1.6396 mL | 4.0989 mL | |
| 25 mM | 0.1312 mL | 0.6558 mL | 1.3116 mL | 3.2791 mL | |
| 30 mM | 0.1093 mL | 0.5465 mL | 1.0930 mL | 2.7326 mL | |
| 40 mM | 0.0820 mL | 0.4099 mL | 0.8198 mL | 2.0494 mL | |
| 50 mM | 0.0656 mL | 0.3279 mL | 0.6558 mL | 1.6396 mL | |
| 60 mM | 0.0547 mL | 0.2733 mL | 0.5465 mL | 1.3663 mL | |
| 80 mM | 0.0410 mL | 0.2049 mL | 0.4099 mL | 1.0247 mL | |
| 100 mM | 0.0328 mL | 0.1640 mL | 0.3279 mL | 0.8198 mL |
And1-IN-1 Related Classifications
HY-150184 Related Classifications
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