2451028-69-4
Chemical Structure
And1-IN-1
- CAS No.: 2451028-69-4
- Formula:C15H11BCl2O2
- Molecular Weight:304.96
IUPAC Name: 7,7''-dibromo-9,9,9',9',9'',9''-hexaoctyl-9H,9'H,9''H-2,2':7',2''-terfluorene
InChIKey: CKTQNMPMPHGBHO-OWOJBTEDSA-N
SMILES: OB1OCC2=CC(/C=C/C3=CC=C(Cl)C(Cl)=C3)=CC=C21
Biological Activity: And1-IN-1 is a potent And1 inhibitor with an IC50 of 2.08 μM. And1-IN-1 binds to the N-terminus of And-1 and induces a conformational change in And-1, which promotes the interaction of And-1 with E3 ligase CUL4B for ubiquitin-mediated degradation. And1-IN-1 suppresses the growth of a broad range of cancers and resensitizes platinum-resistant ovarian cancer cells to platinum agents. And1-IN-1 can be used for the studies of ovarian cancer and breast cancer[1].
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And1-IN-1 | 98.01% | And1-IN-1 is a potent And1 inhibitor with an IC50 of 2.08 μM. And1-IN-1 binds to the N-terminus of And-1 and induces a conformational change in And-1, which promotes the interaction of And-1 with E3 ligase CUL4B for ubiquitin-mediated degradation. And1-IN-1 suppresses the growth of a broad range of cancers and resensitizes platinum-resistant ovarian cancer cells to platinum agents. And1-IN-1 can be used for the studies of ovarian cancer and breast cancer. | ||||||||||||||||||||
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Keywords
