2813310-07-3
2813310-07-3
Chemical Structure
KH-4-43
- CAS No.: 2813310-07-3
- Formula:C19H10ClF3N2O4
- Molecular Weight:422.74
IUPAC Name: 3-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)-7,8-dihydroxy-2-(trifluoromethyl)-4H-chromen-4-one
InChIKey: KDPAGFLLKCODNF-UHFFFAOYSA-N
SMILES: O=C1C2=CC=C(C(O)=C2OC(C(F)(F)F)=C1C3=CN(C4=CC=C(C=C4)Cl)N=C3)O
Biological Activity: KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4's core ligase complex and exhibits anticancer activity. KH-4-43 has a binding Kd to E3 ROC1-CUL4A CTD or the highly related ROC1-CUL1 CTD at 83 nM or 9.4 μM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KH-4-43 | 99.72% | KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4's core ligase complex and exhibits anticancer activity. KH-4-43 has a binding Kd to E3 ROC1-CUL4A CTD or the highly related ROC1-CUL1 CTD at 83 nM or 9.4 μM, respectively. | ||||||||||||||||||||
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References
Keywords
