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delivering mRNA

" in MedChemExpress (MCE) Product Catalog:

46

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2

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21

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2

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1

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1

Click Chemistry

38

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2

GMP Molecules

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134541
    SM-102
    Maximum Cited Publications
    45 Publications Verification

    		 Liposome Infection
    SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .
    SM-102
  • HY-145405
    C12-200
    15+ Cited Publications

    		 Liposome Others
    C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
    C12-200
  • HY-147081
    AS 1411
    2 Publications Verification

    AGRO-100

    		 Histone Methyltransferase Bcl-2 Family Cancer
    AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .
    AS 1411
  • HY-151507
    306Oi10
    1 Publications Verification

    		 Liposome Others
    306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
    306Oi10
  • HY-172723
    DSPE-PEG2000-T7

    		Liposome Transferrin Receptor Neurological Disease Cancer
    DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .
    DSPE-PEG2000-T7
  • HY-46759
    Genevant CL1

    		Liposome Infection
    Genevant CL1 is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 is a component of lipid nanoparticle delivery systems for mRNA vaccines .
    Genevant CL1
  • HY-147332
    TCL053

    		Liposome Neurological Disease
    TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .
    TCL053
  • HY-150229
    306-N16B

    		Liposome Cancer
    306-N16B is a selective lung-targeted lipid nanoparticle that reversibly targets lung endothelial cells and specific immune cells through selective adsorption of a protein corona mediated by differences in tail structure (such as fibrinogen β/γ chain). 306-N16B binds to specific plasma proteins in the blood to form a protein corona, which guides the particles to be enriched in the lungs, releases mRNA and promotes target cell gene expression, exerts efficient lung cell transfection activity, and can precisely regulate gene delivery of different cell types in the lungs (such as endothelial cells and macrophages). 306-N16B can be used in gene therapy technologies for hereditary lung diseases including pulmonary lymphangioleiomyomatosis (LAM), restoring tumor suppressor function by delivering Tsc2 mRNA, and can also be used for lung-specific mRNA vaccines and gene editing therapies .
    306-N16B
  • HY-139306
    BAMEA-O16B

    		Liposome Inflammation/Immunology
    BAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing .
    BAMEA-O16B
  • HY-134541GL
    SM-102 (GMP Like)

    		Liposome Infection
    SM-102 (GMP Like) is SM-102 (HY-134541) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .
    SM-102 (GMP Like)
  • HY-156857
    PPZ-A10

    		Liposome Inflammation/Immunology Cancer
    PPZ-A10 is an ionizable cationic lipid. PPZ-A10 preferentially delivers mRNA to liver and spleen immune cells. Pi-LNPs containing PPZ-A10 can effectively deliver mRNA/siRNA to solid tumors .
    PPZ-A10
  • HY-153377
    Lipid 14

    		Liposome SARS-CoV Bacterial Infection Inflammation/Immunology
    Lipid 14 is an ionizable amino lipid. Lipid 14 delivers mRNA into target cells, significantly enhancing the in vivo expression efficiency and immunogenicity of mRNA. Lipid 14 can be used to synthesize lipid nanoparticles (LNPs). Lipid 14 can be used for studies of SARS-CoV-2 and Yersinia pestis .
    Lipid 14
  • HY-W440915
    DSPE-PEG2000-FITC

    		Liposome Inflammation/Immunology
    DSPE-PEG2000-FITC is a PEG lipid conjugated with fluorescein. FITC is a green dye with a peak absorption at 494 nm and a maximum emission at 520 nm, which is used for staining biological samples or nanoparticles. DSPE-PEG2000-FITC spontaneously forms lipid bilayers or micelles in water and can be used to prepare liposomes for delivering substances such as mRNA vaccines .
    DSPE-PEG2000-FITC
  • HY-134541S6
    SM-102-d4

    		Isotope-Labeled Compounds Liposome Infection
    SM-102-d4 is the deuterium labeled SM-102 (HY-134541). SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .
    SM-102-d4
  • HY-134541G
    SM-102

    		Liposome Infection
    SM-102 (GMP) is SM-102 (HY-134541) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .
    SM-102
  • HY-147081A
    AS 1411 sodium
    2 Publications Verification

    AGRO-100 sodium

    		 Histone Methyltransferase Bcl-2 Family Cancer
    AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 sodium inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 sodium reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. S 1411 sodium works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. S 1411 sodium-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity
    AS 1411 sodium
  • HY-159854
    C14-O2

    		Liposome Cancer
    C14-O2 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
    C14-O2
  • HY-159858
    Lipid 16

    		Liposome Cancer
    Lipid 16 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads. Lipid 16 as a potent cell type-specific ionizable lipid for the CD11bhi macrophage population without an additional targeting moiety .
    Lipid 16
  • HY-156936
    RCB-02-4-8

    		Liposome Others
    RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice .
    RCB-02-4-8
  • HY-W440834
    DSPE-PEG5000-azide

    		Liposome Others
    DSPE-PEG5000-azide is a click chemistry reactive phospholipid polyPEG which forms lipid bilayer or micelles in an aqueous solution. The polymer can be used to prepare liposomes or nanoparticles used for delivering nutrients or therapeutic agents, for example mRNA or DNA vaccine.
    DSPE-PEG5000-azide
  • HY-159709
    VL-422

    		Liposome Metabolic Disease
    VL-422 is an ionizable cationic lipid. VL-422 delivers CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA to enable in vitro and in vivo gene editing. LNPs containing VL-422 loaded with Cas9 mRNA and sgRNA targeting the ANGPTL3 gene induce the deletion of premature stop codons within the ANGPTL3 gene in the liver of cynomolgus monkeys. Loss-of-function of ANGPTL3 leads to decreased levels of LDL, HDL and cholesterol in plasma. The VL-422 delivery system can be used for the research of gene editing strategies targeting lipid metabolism diseases .
    VL-422
  • HY-159865
    CL15F6

    		Liposome Others
    CL15F6 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
    CL15F6
  • HY-159856
    16:0 Cardiolipin

    Diphosphatidylglycerol (16:0)

    		 Liposome Others
    16:0 Cardiolipin (Diphosphatidylglycerol (16:0)) is a phospholipid derived from Palmitic acid (16:0) that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
    16:0 Cardiolipin
  • HY-153737
    113-N16B

    		Liposome Others
    113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
    113-N16B
  • HY-134780
    L-369

    		Liposome Others
    L-369 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles and deliver mRNA .
    L-369
  • HY-159862
    IM21.7c

    		Liposome Infection
    IM21.7c is a cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
    IM21.7c
  • HY-132289
    Lipid M

    		Liposome Inflammation/Immunology
    Lipid M (pKa: 6.75) can be used to deliver mRNA vaccine and yield a robust immune response with improved tolerability .
    Lipid M
  • HY-159869
    G0-C14 analog

    		Liposome Others
    G0-C14 analog is a G0-C14 derivative. G0-C14 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) .
    G0-C14 analog
  • HY-P3402
    HBpep-K

    		Amino Acid Derivatives Others
    HBpep-K is a peptide that can form co aggregated droplets. HBpep-K can efficiently load and deliver small peptides, proteins, and mRNA. HBpep-K can protect mRNA from RNase degradation. HBpep-K is commonly used for drug delivery .
    HBpep-K
  • HY-P3402A
    HBpep-K acetate

    		Amino Acid Derivatives Others
    HBpep-K acetate is a peptide that can form co aggregated droplets. HBpep-K acetate can efficiently load and deliver small peptides, proteins, and mRNA. HBpep-K acetate can protect mRNA from RNase degradation. HBpep-K acetate is commonly used for drug delivery .
    HBpep-K acetate
  • HY-151508
    Diamino lipid DAL4

    		Liposome Cancer
    Diamino lipid DAL4 is diamino lipid for the preparation of lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12, IL-27 and GM-CSF. Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity .
    Diamino lipid DAL4
  • HY-46759A
    Genevant CL1 monohydrochloride

    		Liposome Infection
    Genevant CL1 monohydrochloride is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 monohydrochloride is a component of lipid nanoparticle delivery systems for mRNA vaccines .
    Genevant CL1 monohydrochloride
  • HY-151506
    Phospholipid PL1

    		Liposome Cancer
    Phospholipid PL1 is a phospholipid-derived nanoparticle, can deliver costimulatory receptor mRNA (CD137 or OX40) to T cells. Phospholipid PL1 could induce the activation of various immune cells, including T cells and dendritic cells (DCs) in order to boost antitumor immunity .
    Phospholipid PL1
  • HY-171954
    9C-SCC-10

    		Liposome Cancer
    9C-SCC-10 is a crown-like biodegradable ionizable lipid. 9C-SCC-10 an be used to prepare lipid nanoparticles for delivering mRNA and targeting lung tissue. 9C-SCC-10 can be used for early detection and diagnosis of lung cancer .
    9C-SCC-10
  • HY-159853
    C14-A1

    		Liposome Inflammation/Immunology
    C14-A1 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
    C14-A1
  • HY-159855
    CAP 2 hydrochloride

    Cholesterol-amino-phosphate 2 hydrochloride

    		 Liposome Others
    CAP 2 (Cholesterol-amino-phosphate 2) hydrochloride is Cholesterol-amino-phosphate (CAP) lipid. CAP 2 can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
    CAP 2 hydrochloride
  • HY-176512
    FO-32

    		Liposome Cancer
    FO-32 is an ionizable cationic lipid with a pKa of 6.46 and can be used to generate lipid nanoparticles (LNPs) to deliver mRNA in vivo. FO-32 can efficiently deliver mRNA to ferret lungs. FO-32 can be studied in research on optimizing drug delivery .
    FO-32
  • HY-160908
    Lipid 88

    		Liposome Others
    Lipid 88 is an ionizable cationic lipid. Lipid 88 can be used to synthesize lipid nanoparticles and deliver mRNA .
    Lipid 88
  • HY-160512
    Lipid 9

    		Liposome Others
    Lipid 9 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads .
    Lipid 9
  • HY-W440897
    DSPE-PEG3400-SH

    		Biochemical Assay Reagents Others
    DSPE-PEG3400-SH is a maleimide reactive PEG lipid. The amphiphilic polymer forms lipid bilayer in water and can be used to prepare liposomes for drug nanocarriers to deliver mRNA, DNA or siRNA.
    DSPE-PEG3400-SH
  • HY-W440928
    Stearic acid-PEG3400-NHS

    		Liposome Others
    Stearic acid-PEG3400-NHS is a phospholipid polyPEG which can self-assemble in water to form lipid bilayer. The polymer can be used to prepare liposomes as drug carrier to deliver nutrients/therpeutic agents, such as mRNA or DNA.
    Stearic acid-PEG3400-NHS
  • HY-172334
    2N12B

    		Liposome Metabolic Disease
    2N12B is a bioreducible ionizable lipid containing disulfide bonds. 2N12B can be used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. Lipid nanoparticles containing 2N12B can deliver siRNA to inhibit retinal neovascularization .
    2N12B
  • HY-171953
    THP1 Lipid

    		Liposome Others
    THP1 Lipid is an ionizable lipidoid. THP1 Lipid can be used to synthesize lipid nanoparticles (LNPs) for delivering mRNA to muscles with minimal toxicity and editing genes in specific liver tissues in tdTomato transgenic mice model. THP1 Lipid can be used for vaccine delivery and CRISPR/Cas9-mediated gene editing research .
    THP1 Lipid
  • HY-171984
    514O6,10

    		Liposome Infection Inflammation/Immunology Cancer
    514O6,10 is an ionizable lipidoid containing a branched-tail. 514O6,10 can be used to synthesize lipid nanoparticles (LNPs) for delivering mRNA to natural killer and dendritic cells within the lung. 514O6,10 can be used for the RNA therapies for lung diseases associated with immune cell dysregulation, including cancer, viral infections, and autoimmune disorders research .
    514O6,10
  • HY-W1130456
    Lipid TD5

    		Liposome Inflammation/Immunology
    Lipid TD5 is an ionizable cationic lipid with a pKa of 7.3. Lipid TD5 can be used to generate lipid nanoparticles (LNPs) to deliver mRNA in vitro and in vivo. Lipid TD5 LNPs can undergo endocytosis in a 5-HT receptor subtype 1A-dependent manner in primary mouse astrocytes .
    Lipid TD5
  • HY-157415
    1,2-Dierucoyl-sn-glycero-3-PE

    1,2-Dierucoyl-sn-3-phosphatidylethanolamine; di22:1-PE; PE(22:1/22:1)

    		 Liposome Inflammation/Immunology
    1,2-Dierucoyl-sn-glycero-3-PE (1,2-Dierucoyl-sn-3-phosphatidylethanolamine) is a phospholipid that contains erucic acid. 1,2-Dierucoyl-sn-glycero-3-PE can be used in the generation of lipid nanoparticles (LNPs) to deliver mRNA in vivo. 1,2-Dierucoyl-sn-glycero-3-PE can also be used to synthesize numerous PEG-conjugates for liposomes incorporation .
    1,2-Dierucoyl-sn-glycero-3-PE

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