2430034-05-0
Chemical Structure
Lipid 14
- CAS No.: 2430034-05-0
- Formula:C56H110N2O6
- Molecular Weight:907.48
IUPAC Name: ((2-((4-(dimethylamino)butanoyl)oxy)ethyl)azanediyl)bis(octane-8,1-diyl) bis(2-hexyldecanoate)
InChIKey: NGUVKPMCPAGUDU-UHFFFAOYSA-N
SMILES: O=C(CCCN(C)C)OCCN(CCCCCCCCOC(C(CCCCCCCC)CCCCCC)=O)CCCCCCCCOC(C(CCCCCCCC)CCCCCC)=O
Biological Activity: Lipid 14 is an ionizable amino lipid. Lipid 14 delivers mRNA into target cells, significantly enhancing the in vivo expression efficiency and immunogenicity of mRNA. Lipid 14 can be used to synthesize lipid nanoparticles (LNPs). Lipid 14 can be used for studies of SARS-CoV-2 and Yersinia pestis[1][2].
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Lipid 14 | 95.0% | Lipid 14 is an ionizable amino lipid. Lipid 14 delivers mRNA into target cells, significantly enhancing the in vivo expression efficiency and immunogenicity of mRNA. Lipid 14 can be used to synthesize lipid nanoparticles (LNPs). Lipid 14 can be used for studies of SARS-CoV-2 and Yersinia pestis. | ||||||||||||||||||||
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- [1]. Elia U, et al. Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles. ACS Nano. 2021 Jun 22;15(6):9627-9637. [Content Brief]
- [2]. Kon E, et al. A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium. Sci Adv. 2023 Mar 10;9(10):eadg1036. [Content Brief]
Keywords
