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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
ecto-domain
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "ecto-domain" in MCE Product Catalog:
2
2 Cited Publications
1
Cat. No.: HY-P3325
CAS No.: 2147724-76-1
Synonyms: D-P8RI
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Cat. No.: HY-P99556
CAS No.: 2420564-02-7
Synonyms: AZD8895; COV2-2196
Cat. No.: HY-N3942
CAS No.: 41983-91-9
Category:
Infection Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.
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RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth .
Cat. No.: HY-P99856
CAS No.: 2247196-23-0
Synonyms: 62-71-3
Cat. No.: HY-177710
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MEDI4276 is a biparatopic tetravalent antibody targeting two nonoverlapping epitopes in subdomains 2 and 4 of the HER2 ecto-domain. MEDI4276 is composed of MEDI4276 Antibody (HY-P991238) and a cytotoxic payload AZ1508 (HY-128962) linked through site-specific coupling. MEDI4276 exhibits antitumor activity .
Cat. No.: HY-P99963
CAS No.: 2387417-06-1
Synonyms: HS636
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Cat. No.: HY-P10829
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Cat. No.: HY-174529
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Human TGFBR3 mRNA encodes the human transforming growth factor beta receptor 3 (TGFBR3) protein, a transforming growth factor (TGF)-beta type III receptor. TGFBR3 is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers.
Cat. No.: HY-P11863
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Cat. No.: HY-182702
CAS No.: 1214405-38-5
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As48 is a selective TREM2 agonist with a KD value of 12.48 μM in TRIC binding assay. As48 binds near the TREM2 cleavage region, forms hydrogen bonds with Gly68, reduces conformational flexibility in regions 58-102, restricts protease accessibility to the cleavage site. As48 activates SYK phosphorylation, enhances microglial phagocytosis, and induces downstream calcium signaling in TREM2-expressing cells. As48 inhibits TREM2 ectodomain shedding without affecting ADAM10/17 protease activities. As48 can be used for the research of Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
