1214405-38-5
Chemical Structure
As48
- CAS No.: 1214405-38-5
- Formula:C20H15N3OS
- Molecular Weight:345.42
InChIKey: PUTAEPSTVVIYFM-UHFFFAOYSA-N
SMILES: O=C(N1C2=C(CC1)C=C(C3=CN4C=CC=CC4=N3)C=C2)C5=CC=CS5
Biological Activity: As48 is a selective TREM2 agonist with a KD value of 12.48 μM in TRIC binding assay. As48 binds near the TREM2 cleavage region, forms hydrogen bonds with Gly68, reduces conformational flexibility in regions 58-102, restricts protease accessibility to the cleavage site. As48 activates SYK phosphorylation, enhances microglial phagocytosis, and induces downstream calcium signaling in TREM2-expressing cells. As48 inhibits TREM2 ectodomain shedding without affecting ADAM10/17 protease activities. As48 can be used for the research of Alzheimer's disease[1].
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As48 | As48 is a selective TREM2 agonist with a KD value of 12.48 μM in TRIC binding assay. As48 binds near the TREM2 cleavage region, forms hydrogen bonds with Gly68, reduces conformational flexibility in regions 58-102, restricts protease accessibility to the cleavage site. As48 activates SYK phosphorylation, enhances microglial phagocytosis, and induces downstream calcium signaling in TREM2-expressing cells. As48 inhibits TREM2 ectodomain shedding without affecting ADAM10/17 protease activities. As48 can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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Keywords
