13 Results for "

hemolysin

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "hemolysin" in MCE Product Catalog:

7
7 Cited Publications
Cat. No.: HY-110082
CAS No.: 130-89-2
Quinine hydrochloride is an alkaloid extracted from cinchona bark and exhibits oral activity, acting as a potassium channel inhibitor. Quinine hydrochloride modulates the tolerance of red blood cells and presents dose-dependent toxicity and embryonic effects. Quinine hydrochloride is a typical hemolysin that directly lyses red blood cells, with cellular components of red blood cell membranes as its action targets. Quinine hydrochloride disrupts red blood cell membranes and induces hemolysis at high concentrations, while merely weakening the anti-hemolytic capacity of red blood cells at low concentrations. Quinine hydrochloride continuously reduces red blood cell tolerance after in vivo administration, and high doses can also alter blood cell counts. Quinine hydrochloride can be applied to researches related to red blood cell hemolysis, cancer and malaria .
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1 Cited Publications
Cat. No.: HY-P71454
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: lukF; Leukocidin-F subunit; Gamma-hemolysin; H-gamma-I subunit
Species:  
Source:  
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Cat. No.: HY-P5492
CAS No.: 74838-20-3
Synonyms: Delta-lysin
Target:  

Bacterial

Research Areas:  

Others

Delta-hemolysin (Delta-lysin), a 26 amino acid peptide, is a hemolytic peptide produced by Staphylococcus. Delta-hemolysin may slightly perturb a membrane or lead to cell lysis. Delta-hemolysin is a model in the study of peptides interacting with membranes. Delta-hemolysin is poorly active against bacteria .
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Cat. No.: HY-N2245
CAS No.: 98619-25-1
Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera . Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia .
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Cat. No.: HY-P99551
CAS No.: 1374419-41-6
Synonyms: KBSA301; AR-301

Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent. Recommend Isotope Control: Human IgG1 lambda1, Isotype Control (HY-P99992) .
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Cat. No.: HY-173526
CAS No.: 2886748-00-9
Research Areas:  

Infection

H052 is a selective Staphylococcus aureus α-hemolysin (Hla) inhibitor. H052 binds to Hla monomers, disrupts the interaction with host cell membranes to block pore formation, inhibiting calcium ion influx, cytotoxicity, and inflammatory responses. H052 exhibits potency (EC50=30 nM in U937 cells) against Hla-induced calcium influx. H052 is promising for research of lung infections caused by S. aureus .
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Cat. No.: HY-P5492A
Synonyms: Delta-lysin TFA
Target:  

Bacterial

Research Areas:  

Others

Delta-hemolysin (Delta-lysin) TFA, a 26 amino acid peptide, is a hemolytic peptide produced by Staphylococcus. Delta-hemolysin TFA may slightly perturb a membrane or lead to cell lysis. Delta-hemolysin TFA is a model in the study of peptides interacting with membranes. Delta-hemolysin TFA is poorly active against bacteria .
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Cat. No.: HY-124469
CAS No.: 1799734-10-3
Target:  

Bacterial

Research Areas:  

Infection

UM-C162, a benzimidazole derivative, can rescue nematodes from a S. aureus infection. UM-C162 prevents the formation of biofilm without interfering with bacterial viability. UM-C162 mediates the disruption of S. aureus hemolysins, proteases and clumping factors production. UM-C162 has the potential to be used as an anti-virulence agent to control S. aureus infections .
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Cat. No.: HY-E70983
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Antistreptolysin O, Human is a hemolysin produced by group A streptococci. As a protein antigen, Antistreptolysin O, Human triggers an antibody response in the body.
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Cat. No.: HY-P71835
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: hlgC; SA2208Gamma-hemolysin component C
Species:  
Source:  
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Cat. No.: HY-P71806
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: hlgB; SA2209; Gamma-hemolysin component B; H-gamma-1; H-gamma-I
Species:  
Source:  
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Cat. No.: HY-P71485
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: hlgA; hlg2; MW2342; Gamma-hemolysin component A; H-gamma-2; H-gamma-II
Species:  
Source:  
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Cat. No.: HY-131920
CAS No.: 27416-86-0
Synonyms: Polyuridylic acid
Poly (U) (Polyuridylic acid) is an RNA chain that exists in a disordered extended state at room temperature and serves as a TLR7 ligand. Poly (U) produces distinguishable blocking effects when transported through α-hemolysin nanopores. Poly (U) forms a triple helix with adenosine or adenosine monophosphate, thereby significantly promoting the nucleotide bond condensation reaction between adenosine monophosphate and adenosine, while exerting minimal effects on other nucleosides. When conjugated with cationic lipids, Poly (U) specifically stimulates plasmacytoid dendritic cells to produce type I interferons .
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