18 Results for "

human TIM-3

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "human TIM-3" in MCE Product Catalog:

  • Targets Recommended:
1
1 Cited Publications
Cat. No.: HY-P81703
Synonyms: CD366 antibody; FLJ14428 antibody; HAVcr-2 antibody; Havcr2 antibody; HAVR2_human antibody; Hepatitis A virus cellular receptor 2 antibody; Kidney injury molecule 3 antibody; KIM 3 antibody; KIM3 antibody; T cell immunoglobulin and mucin domain containing 3 antibody; T cell immunoglobulin mucin 3 antibody; T-cell immunoglobulin and mucin domain-containing protein 3 antibody; T-cell immunoglobulin mucin family member 3 antibody; T-cell immunoglobulin mucin receptor 3 antibody; T-cell membrane protein 3 antibody; TIM 3 antibody; TIM-3 antibody; TIM3 antibody; TIMD-3 antibody; TIMD3 antibody;

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, FC

Reactivity:  

Human

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Cat. No.: HY-155175
CAS No.: 1113126-49-0
Purity:  98.93%
Target:  

Tim3 IFNAR

Research Areas:  

Cancer

TIM-3-IN-2 is a TIM-3 inhibitor. TIM-3-IN-2 blocks the interactions of TIM-3 with PtdSer, CEACAM1 and Gal-9, and inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 restores IFNγ release from peripheral blood mononuclear cells. TIM-3-IN-2 inhibits the proliferation of acute myeloid leukemia cells. TIM-3-IN-2 can be used for the research of acute myeloid leukemia .
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Cat. No.: HY-P99962
CAS No.: 2342597-90-2
Synonyms: BGB-A425

Target:  

Mucin

Research Areas:  

Cancer

Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer .
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Cat. No.: HY-P991198

Target:  

Tim3

Research Areas:  

Cancer

M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM). M6903 binds to TIM-3, blocking the binding of TIM-3 to phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9), thus relieving TIM-3-mediated T cell inhibition and exerting the activities of activating antigen-specific T cells and enhancing anti-tumor immunity. M6903 is promising for research of cancers .
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Cat. No.: HY-P991396

Target:  

Tim3

Research Areas:  

Cancer

LY-3321367 is a humanized IgG1 monoclonal antibody targeting TIM-3. LY-3321367 partially blocks the formation of the TIM-3/GAL-9 complex, completely blocks the binding of TIM-3 to phosphatidylserine, but does not block the formation of the TIM-3/CEACAM-1 complex. LY-3321367 is applicable to research related to various solid tumors, such as small cell lung cancer .
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Cat. No.: HY-159884
CAS No.: 328540-44-9
Target:  

Tim3 TNF Receptor IFNAR

Research Areas:  

Cancer

MG-T-19 is a potent small-molecule inhibitor targeting human TIM-3. MG-T-19 blocks the interactions between TIM-3 and its ligands such as phosphatidylserine, CEACAM1 and Galectin-9. MG-T-19 promotes the secretion of TNF-α and IFN-γ by peripheral blood mononuclear cells, and significantly enhances their ability to inhibit cancer cell proliferation. MG-T-19 can be used in studies related to acute myeloid leukemia .
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Cat. No.: HY-P991395

Target:  

Tim3

Research Areas:  

Cancer

TQB2618 is a human IgG4 monoclonal antibody (mAb) targeting TIM-3/HAVCR2/CD366. TQB2618 activates immune cell function and induces significant anti-tumor activity when used in combination with anti-PD-1 agents .
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Cat. No.: HY-P991397

Target:  

Tim3

Research Areas:  

Cancer

Sym023 is a human monoclonal antibody (mAb) targeting TIM-3/HAVCR2/CD366. Sym023 enhances immunostimulatory and anti-tumor activities. Sym023 can be used in Non-small cell lung cancer, Solid tumors and Lymphoma research .
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Cat. No.: HY-P78217
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD366; TIM3; TIM-3; TIMD-3; TIM 3;  FLJ14428; HAVCR2; KIM3
Species:  
Source:  
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Cat. No.: HY-P992342

Target:  

Tim3

Research Areas:  

Cancer

DCB-8 is a specific inhibitor targeting human TIM-3. DCB-8 regulates T cell function, enhances cytokine secretion, and inhibits tumor growth in disease animal models. DCB-8 can be used for cancer research .
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Cat. No.: HY-P992398

Target:  

Tim3

Research Areas:  

Cancer

LBL-003 is a fully human monoclonal antibody targeting TIM-3. LBL-003 can be used for cancer research.
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Cat. No.: HY-P990716
CAS No.: 2648346-74-9
Synonyms: AZD7789

Target:  

PD-1/PD-L1 Tim3

Research Areas:  

Inflammation/Immunology

Sabestomig (AZD7789) is a monovalent bispecific antibody targeting PD-1 and TIM-3. Sabestomig binds to PD-1 and an epitope in the TIM-3 IgV domain outside the phosphatidylserine-binding cleft, thereby precisely regulating immune responses. Sabestomig promotes IL-2 production, efferocytosis and cross-presentation of tumor antigens, and enhances the release of anti-tumor T cell cytokines, cytotoxicity, and secretion of IFN-γ. Sabestomig inhibits the growth of solid tumors, prolongs the duration of tumor suppression, and significantly enhances anti-tumor responses following anti-PD-1 therapy. Sabestomig has been used in studies related to non-small cell lung cancer and classical Hodgkin lymphoma .
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Cat. No.: HY-P992454

Target:  

Tim3

Research Areas:  

Cancer

S095018 (Sym023) is a human IgG2-type inhibitor targeting T cell immunoglobulin and TIM-3. S095018 competitively blocks the binding of multiple ligands such as Gal-9 and phosphatidylserine to TIM-3. S095018 stimulates the anti-tumor activity of T cells, dendritic cells and macrophages, and exhibits good safety both as a monotherapy and in combination with the anti-PD-1 antibody Sym021. S095018 also induces an increase in the density of CD8 + T cells in the tumor microenvironment, and upregulates gene signatures associated with IFN-γ signaling, antigen presentation and T cell activation. S095018 can be used for the research of advanced/metastatic recurrent biliary tract cancer .
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Cat. No.: HY-P70482
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Hepatitis A Virus Cellular Receptor 2; HAVcr-2; T-Cell Immunoglobulin and Mucin Domain-Containing Protein 3; TIMD-3; T-Cell Membrane Protein 3; TIM-3; HAVCR2; TIM3; TIMD3
Species:  
Source:  
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Cat. No.: HY-P70812
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell membrane protein 3; FLJ14428; KIM-3; TIM-3; TIM3; TIMD3
Species:  
Source:  
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Cat. No.: HY-P72419
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Hepatitis A virus cellular receptor 2; HAVcr-2; TIMD-3; TIM-3; T-cell membrane protein 3; HAVCR2; TIMD3
Species:  
Source:  
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Cat. No.: HY-P7415
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuTIM-3, Fc Chimera; TIMD-3; CD366; HAVCR2
Species:  
Source:  
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Cat. No.: HY-P704923
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuTIM-3, Fc Chimera; TIMD-3; CD366; HAVCR2
Species:  
Source:  
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