human TREM2

By Targets:	TREM receptor (12) Calcium Channel (1) Ser/Thr Kinase (1) Small Interfering RNA (siRNA) (1) Syk (2)
By Research Areas:	Cancer (1) Inflammation/Immunology (6) Neurological Disease (6)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Targets Recommended: TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10136

IA9 2 Publications Verification human TREM-2 182-190	TREM receptor	Inflammation/Immunology
IA9 (human TREM-2 182-190) is a potent, CNS-penetrant *TREM-2* inhibitor. IA9 can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 can be used for neuroinflammation PET imaging. IA9 can be used for Rheumatoid arthritis (RA) and neuroinflammation research .

HY-P991220

AL002	TREM receptor	Neurological Disease
AL002 is a humanized monoclonal IgG1 antibody and a blood-brain barrier-permeable TREM2 modulator. AL002 binds to TREM2 on the surface of microglia, promotes TREM2 clustering and the formation of the TREM2-DAP12 complex, activates the TREM2 signaling pathway and PI3K cascade, and induces TREM2 internalization and degradation. AL002 is applicable to research related to Alzheimer's disease .

HY-P990043

Iluzanebart VGL101	Ser/Thr Kinase TREM receptor	Inflammation/Immunology
Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP) .

HY-P991734

VHB937	TREM receptor Syk Calcium Channel	Neurological Disease Inflammation/Immunology
VHB937 is a potent and selective *TREM2* agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research .

HY-P991442

DNL-919 (Human IgG1) TAK-920	TREM receptor	Neurological Disease
DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting *TREM-2. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human* IgG1 kappa, Isotype Control (HY-P99001) .

HY-P10136A

IA9 TFA 2 Publications Verification human TREM-2 182-190 TFA	TREM receptor	Inflammation/Immunology
IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant *TREM-2* inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research .

HY-P991621

EOS006215 EOS-215	TREM receptor	Cancer
EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer .

HY-RS15003

TREM2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TREM2 Human Pre-designed siRNA Set A contains three designed siRNAs for TREM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TREM2 Human Pre-designed siRNA Set A TREM2 Human Pre-designed siRNA Set A

HY-P991174

Anti-TREM2 Antibody (AL2p-58)	TREM receptor	Inflammation/Immunology
Anti-TREM2 Antibody (AL2p-58) is a humanized IgG1 monoclonal antibody targeting *TREM2. Anti-TREM2* Antibody (AL2p-58) can be used for the research of neuroinflammation. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992118

Lifonebart	TREM receptor	Inflammation/Immunology
Lifonebart is a humanized monoclonal antibody targeting *TREM2* (triggering receptor expressed on myeloid cells 2). The antibody isotype of Lifonebart is human IgG1κ, and the recommended isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992516

DNL-919 (ATV)	TREM receptor	Neurological Disease
DNL-919 ATV is a brain-penetrant TREM2 agonist. DNL-919 ATV induces responsive microglial cell state changes and modulates microglial biomarkers. DNL-919 ATV can be used for the research of Alzheimer's disease .

HY-P992513

Anti-Mouse TREM2 Antibody (4D9)	TREM receptor	Neurological Disease
Anti-Mouse TREM2 Antibody (4D9) is a monoclonal antibody targeting TREM2. Anti-Mouse TREM2 Antibody (4D9) enhances microglial signaling, induces reversible morphological changes in microglia, converts microglia into a metabolically responsive state, and increases the state diversity of microglia. Anti-Mouse TREM2 Antibody (4D9) can be used in studies related to Alzheimer's disease .

HY-182702

As48	TREM receptor Syk	Neurological Disease
As48 is a selective TREM2 agonist with a K_D value of 12.48 μM in TRIC binding assay. As48 binds near the TREM2 cleavage region, forms hydrogen bonds with Gly68, reduces conformational flexibility in regions 58-102, restricts protease accessibility to the cleavage site. As48 activates SYK phosphorylation, enhances microglial phagocytosis, and induces downstream calcium signaling in TREM2-expressing cells. As48 inhibits TREM2 ectodomain shedding without affecting ADAM10/17 protease activities. As48 can be used for the research of Alzheimer's disease .

Cat. No.	Product Name	Target	Research Area

HY-P10136

IA9 2 Publications Verification human TREM-2 182-190	TREM receptor	Inflammation/Immunology
IA9 (human TREM-2 182-190) is a potent, CNS-penetrant *TREM-2* inhibitor. IA9 can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 can be used for neuroinflammation PET imaging. IA9 can be used for Rheumatoid arthritis (RA) and neuroinflammation research .

HY-P10136A

IA9 TFA 2 Publications Verification human TREM-2 182-190 TFA	TREM receptor	Inflammation/Immunology
IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant *TREM-2* inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991220

AL002	TREM receptor	Neurological Disease
AL002 is a humanized monoclonal IgG1 antibody and a blood-brain barrier-permeable TREM2 modulator. AL002 binds to TREM2 on the surface of microglia, promotes TREM2 clustering and the formation of the TREM2-DAP12 complex, activates the TREM2 signaling pathway and PI3K cascade, and induces TREM2 internalization and degradation. AL002 is applicable to research related to Alzheimer's disease .

HY-P990043

Iluzanebart VGL101	Ser/Thr Kinase TREM receptor	Inflammation/Immunology
Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP) .

HY-P991734

VHB937	TREM receptor Syk Calcium Channel	Neurological Disease Inflammation/Immunology
VHB937 is a potent and selective *TREM2* agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research .

HY-P991442

DNL-919 (Human IgG1) TAK-920	TREM receptor	Neurological Disease
DNL-919 (TAK-920) is a human IgG1 monoclonal antibody (mAb) targeting *TREM-2. DNL-919 can be used in Alzheimer's disease research. Recommended isotype control: Human* IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991621

EOS006215 EOS-215	TREM receptor	Cancer
EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer .

HY-P991174

Anti-TREM2 Antibody (AL2p-58)	TREM receptor	Inflammation/Immunology
Anti-TREM2 Antibody (AL2p-58) is a humanized IgG1 monoclonal antibody targeting *TREM2. Anti-TREM2* Antibody (AL2p-58) can be used for the research of neuroinflammation. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992118

Lifonebart	TREM receptor	Inflammation/Immunology
Lifonebart is a humanized monoclonal antibody targeting *TREM2* (triggering receptor expressed on myeloid cells 2). The antibody isotype of Lifonebart is human IgG1κ, and the recommended isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992516

DNL-919 (ATV)	TREM receptor	Neurological Disease
DNL-919 ATV is a brain-penetrant TREM2 agonist. DNL-919 ATV induces responsive microglial cell state changes and modulates microglial biomarkers. DNL-919 ATV can be used for the research of Alzheimer's disease .

HY-P992513

Anti-Mouse TREM2 Antibody (4D9)	TREM receptor	Neurological Disease
Anti-Mouse TREM2 Antibody (4D9) is a monoclonal antibody targeting TREM2. Anti-Mouse TREM2 Antibody (4D9) enhances microglial signaling, induces reversible morphological changes in microglia, converts microglia into a metabolically responsive state, and increases the state diversity of microglia. Anti-Mouse TREM2 Antibody (4D9) can be used in studies related to Alzheimer's disease .

Species:	Human (5)
Tag:	His (2) Avi (1) Fc (3)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78222

	TREM-2 Protein, Human (Biotinylated, HEK293, His-Avi) PLOSL2; TREM2; TREM-2; TREM2a; TREM2b; TREM2c	Human	HEK293
	TREM-2 Protein is a receptor for amyloid beta protein 42, lipoprotein particles, and apolipoprotein. TREM-2 Protein is involved in cell proliferation and apoptosis through Wnt/β, MTOR, PI3K and NF-kappa-B signaling pathways. TREM-2 Protein is expressed by macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia to activate the immune response. TREM-2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TREM-2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P70534

	TREM-2 Protein, Human (HEK293, His) Triggering receptor expressed on myeloid cells 2; TREM-2; Triggering receptor expressed on monocytes 2; TREM2	Human	HEK293
	TREM-2 Protein is a receptor for amyloid beta protein 42, lipoprotein particles, and apolipoprotein. TREM-2 Protein is involved in cell proliferation and apoptosis through Wnt/β, MTOR, PI3K and NF-kappa-B signaling pathways. TREM-2 Protein is expressed by macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia to activate the immune response. TREM-2 Protein, Human (HEK293, His) is the recombinant human-derived TREM-2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704937

	TREM-2 Protein, Human (HEK293, mFc) Triggering receptor expressed on myeloid cells 2; TREM-2; Triggering receptor expressed on monocytes 2; TREM2	Human	HEK293

HY-P704938

	TREM-2 Protein, Human (HEK293, Fc) Triggering receptor expressed on myeloid cells 2; TREM-2; Triggering receptor expressed on monocytes 2; TREM2	Human	HEK293

HY-P704939

	TREM-2 Protein, Human (113a.a, HEK293, Fc) Triggering receptor expressed on myeloid cells 2; TREM-2; Triggering receptor expressed on monocytes 2; TREM2	Human	HEK293

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HY-RS15003

TREM2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TREM2 Human Pre-designed siRNA Set A contains three designed siRNAs for TREM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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