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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
humanized mouse model
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "humanized mouse model" in MCE Product Catalog:
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Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models) .
Cat. No.: HY-P99056
CAS No.: 1417318-27-4
Synonyms: PF 05082566
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Cat. No.: HY-P99728
CAS No.: 2056881-92-4
Synonyms: RG7835; RO7049665
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Cat. No.: HY-P99697
CAS No.: 674782-26-4
Synonyms: PRO 140
Cat. No.: HY-P991363
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Cat. No.: HY-P990993
CAS No.: 2922218-19-5
Synonyms: GYM-329, RG6237, RG-70240
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Cat. No.: HY-P991598
CAS No.: 2304625-87-2
Synonyms: MOR12743; MOR03207
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ARB-272572 is an oral effective small molecule PD-L1 inhibitor, with an IC50 value of 400 pM. ARB-272572 has research significance in tumors and chronic viral infections .
Cat. No.: HY-P99249
CAS No.: 1638935-72-4
Synonyms: Pogalizumab; MOXR 0916
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Cat. No.: HY-P990025
CAS No.: 2579031-19-7
Synonyms: ARGX-117
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Cat. No.: HY-175370
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PROTAC RIPK1 Degrader-1 is a selective RIPK1 PROTAC degrader. PROTAC RIPK1 Degrader-1 degrades RIPK1 in multiple cancer cell lines (e.g., A375, B16F10 cells). PROTAC RIPK1 Degrader-1 enhances the anti-cancer effect of radiotherapy in syngeneic and humanized mouse models. PROTAC RIPK1 Degrader-1 can be used to study cancers such as melanoma .
Cat. No.: HY-P99809
CAS No.: 2254059-25-9
Synonyms: MK-1308
Cat. No.: HY-P991674
CAS No.: 3033337-14-0
Synonyms: BJT-778
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Cat. No.: HY-P991230
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Cat. No.: HY-170780
CAS No.: 3109381-06-5
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DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model .
Cat. No.: HY-P991646
Synonyms: heMab
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Cat. No.: HY-111141
CAS No.: 916219-50-6
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AM-3189 is an orally active and selective GPR40 agonist with EC50 values in buffer solution and in 100% human serum of 33 nM and 10 μM respectively. AM-3189 shows no significant activity on GPR41 and GPR43, and no agonistic activity on PPAR-α, -δ, and -γ. AM-3189 enhances glucose-stimulated insulin secretion by activating GPR40 on pancreatic β cells. AM-3189 has extremely low penetration into the central nervous system and significantly reduces blood glucose levels in two humanized GPR40 mouse models. AM-3189 can be used for the study of type 2 diabetes .
Cat. No.: HY-P991432
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Cat. No.: HY-163837
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PD-1/PD-L1-IN-48 (compound HD10) is a potent inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.1 nM. PD-1/PD-L1-IN-48 plays an important role in cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
