PD-1/PD-L1-IN-48
PD-1/PD-L1-IN-48 (compound HD10) is a potent inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.1 nM. PD-1/PD-L1-IN-48 plays an important role in cancer research.
For research use only. We do not sell to patients.
- Formula: C32H29F2N3O5
- Molecular Weight:573.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MC-38 | IC50 |
>8 μM
Compound: HD10
|
Antiproliferative activity against mouse MC38 cells expressing hPD-L1 incubated for 48 hrs by CCK8 assay
Antiproliferative activity against mouse MC38 cells expressing hPD-L1 incubated for 48 hrs by CCK8 assay
|
[PMID: 39032403] |
Chemical Information
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Molecular Weight 573.59
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Formula C32H29F2N3O5
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SMILES
N#CC1=CN=CC(COC2=CC(OCC3=C(C(C4=CC5=C(OCCO5)C=C4)=CC=C3)C(F)F)=CC=C2CNCCO)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)