Melredableukin alfa  (Synonyms: RG7835; RO7049665)

Melredableukin alfa (RG7835) is a bivalent conjugate composed of a human IL-2 mutant (T3A, N88D, C125A) and human IgG1. Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models. Melredableukin alfa can be used in research related to ulcerative colitis and autoimmune hepatitis^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Single-dose IgG-(IL-2N88D)₂ induces a sustained 10- to 14-fold expansion of functionally suppressive CD4^pos, CD8^pos CD25^pos FOXP3^pos regulatory T cells in humanized NSG mice and cynomolgus monkeys^[1].
Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

175.32 kDa

2056881-92-4

Liquid

Colorless to light yellow

[Melredableukin alfa]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG1 kappa

• [1]. Lykhopiy V, et al. IL-2 immunotherapy for targeting regulatory T cells in autoimmunity". Genes Immun. 2023 Oct;24(5):248-262.  [Content Brief]

  [2]. Efe O, et al. A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models. J Clin Invest. 2024;134(5):e173107. Published 2024 Mar 1.  [Content Brief]