Melredableukin alfa
Based on 1 Customer Validation
Melredableukin alfa (RG7835) is a bivalent conjugate composed of a human IL-2 mutant (T3A, N88D, C125A) and human IgG1. Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models. Melredableukin alfa can be used in research related to ulcerative colitis and autoimmune hepatitis.
For research use only. We do not sell to patients.
- Purity: 96.22%
- CAS No.: 2056881-92-4
- Molecular Weight:175.32 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
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IL-2 |
Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2056881-92-4
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Appearance Liquid
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Molecular Weight 175.32 kDa
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Color Colorless to light yellow
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SMILES
[Melredableukin alfa]
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Synonyms
RG7835; RO7049665
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Lykhopiy V, et al. IL-2 immunotherapy for targeting regulatory T cells in autoimmunity". Genes Immun. 2023 Oct;24(5):248-262. [Content Brief]
[2]. Efe O, et al. A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models. J Clin Invest. 2024;134(5):e173107. Published 2024 Mar 1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Melredableukin alfa Related Classifications
Cat. No.: HY-P99728
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- Melredableukin alfa
- 2056881-92-4
- RG7835
- RO7049665
- RG 7835
- RG-7835
- RO7049665
- RO 7049665
- RO-7049665
- Interleukin Related
- cynomolgus monkeys
- CD4-positive regulatory T cells
- CD56bright NK cells
- humanized mouse models
- CD8-positive regulatory T cells
- ulcerative colitis
- FOXP3-positive regulatory T cells
- interleukin-2 receptor alpha (CD25)
- immunosuppressive agent
- Treg
- Inhibitor
- inhibitor
- inhibit