2056881-92-4
2056881-92-4
Chemical Structure
Melredableukin alfa
Synonym(s): RG7835; RO7049665
- CAS No.: 2056881-92-4
- Formula:N/A
- Molecular Weight:(175.32 kDa)
IUPAC Name: 3-(chloromethyl)-5-(difluoromethyl)pyridine
SMILES: [Melredableukin alfa]
Biological Activity: Melredableukin alfa (RG7835) is a bivalent conjugate composed of a human IL-2 mutant (T3A, N88D, C125A) and human IgG1. Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models. Melredableukin alfa can be used in research related to ulcerative colitis and autoimmune hepatitis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Melredableukin alfa | 96.22% | Melredableukin alfa (RG7835) is a bivalent conjugate composed of a human IL-2 mutant (T3A, N88D, C125A) and human IgG1. Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models. Melredableukin alfa can be used in research related to ulcerative colitis and autoimmune hepatitis. | ||||||||||||||||||||
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References
- [1]. Lykhopiy V, et al. IL-2 immunotherapy for targeting regulatory T cells in autoimmunity". Genes Immun. 2023 Oct;24(5):248-262. [Content Brief]
- [2]. Efe O, et al. A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models. J Clin Invest. 2024;134(5):e173107. Published 2024 Mar 1. [Content Brief]
Keywords
