3109381-06-5
3109381-06-5
Chemical Structure
DSM1465
- CAS No.: 3109381-06-5
- Formula:C17H12ClF6N5O2
- Molecular Weight:467.75
InChIKey: AYPNKXCMMPXJPL-OAHLLOKOSA-N
SMILES: O=C1C2=NN(C)C([C@](O)(C3=CC(Cl)=C(C(F)(F)F)N=C3)C(F)(F)F)=C2N=CN1C4CC4
Biological Activity: DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DSM1465 | 98.99% | DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model. | ||||||||||||||||||||
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References
Keywords
