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Results for "

hyphal formation

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Peptides

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124833
    Quinalizarin

    		Casein Kinase Apoptosis Fungal Reactive Oxygen Species (ROS) Caspase MDM-2/p53 PARP Bcl-2 Family Akt ERK STAT JNK p38 MAPK CDK Infection Cancer
    Quinalizarin is a protein kinase CK2 inhibitor with a Ki of 0.052 μM. Quinalizarin exhibits antifungal and anticancer activities. Quinalizarin induces ROS production, apoptotic signaling, mitochondrial pathway activation, cell cycle arrest, and cytotoxicity in cancer cells. Quinalizarin inhibits hyphal growth, biofilm formation, and mature biofilm integrity of Candida albicans. Quinalizarin can be used in research related to cancer and fungal infections .
    Quinalizarin
  • HY-P10304A
    Cyclo(Arg-Pro) TFA

    Cyclo(Pro-Arg) TFA

    		 Fungal Infection
    Cyclo (Arg-Pro) TFA is a chitinase inhibitor. Cyclo (Arg-Pro) TFA disrupts cell separation and morphological transition of yeast by inhibiting chitinase activity. Cyclo (Arg-Pro) TFA prevents cell separation of Saccharomyces cerevisiae, leading to the formation of grape-like cell clusters, without inhibiting cell growth. Cyclo (Arg-Pro) TFA blocks the morphological transition of Candida albicans from yeast form to hyphal form, without inhibiting cell growth .
    Cyclo(Arg-Pro) TFA
  • HY-W142410
    2-Dodecanol

    		Fungal Others
    2-Dodecanol inhibits hyphal formation and SIR2 expression in C. albicans .
    2-Dodecanol
  • HY-179518
    Antifungal agent 140

    		Fungal PKA Ras Infection
    Antifungal agent 140 (compound 5p) is a potent antifungal agent with broad-spectrum antifungal activity. Antifungal agent 140 exerts a dual mechanism by targeting the Ras/cAMP/PKA pathway to inhibit hyphal formation and the ergosterol biosynthesis pathway. Antifungal agent 140 enhances survival, reduces fungal load in the kidneys, and strengthens host immune responses in a murine model of systemic candidiasis. Antifungal agent 140 can be used for research of resistant fungal infections .
    Antifungal agent 140
  • HY-181511
    CYP51-IN-32

    		Cytochrome P450 Fungal Infection
    CYP51-IN-32 is an antifungal agent with an IC50 of 0.331 μM against CYP51 of Candida albicans. CYP51-IN-32 releases hydrogen sulfide (H2S) and inhibits hyphal formation and biofilm development of Candida albicans. CYP51-IN-32 can be formulated into PEG-based nanovesicles. CYP51-IN-32 is applicable to the research of Candida albicans infection .
    CYP51-IN-32
  • HY-175699
    Antimicrobial agent-42

    		Fungal Infection
    Antimicrobial agent-42 (Compound 6j) is an antimicrobial agent. Antimicrobial agent-42 interacts with key amino acids such as Lys59 and Ser170 within the ALS3 protein, crucial for the binding of host peptides. Antimicrobial agent-42 significantly inhibits Candida albicans biofilm formation and reduces planktonic cells aggregation and hyphal formation. Antimicrobial agent-42 has an antifungal activity, promising for fungal infections reseach .
    Antimicrobial agent-42
  • HY-183333
    CHNQD-02204

    		Fungal Infection
    CHNQD-02204 is a potent and selective antifungal agent with in vitro activity against Candida albicans, with a MIC of 0.025 μg/mL. CHNQD-02204 inhibits ergosterol biosynthesis, disrupts the membrane integrity and biofilm formation of Candida albicans, and suppresses the morphological transition of Candida albicans from yeast to hyphal form. CHNQD-02204 can be used in studies related to candidal infections .
    CHNQD-02204
  • HY-N19791
    6-Methoxymellein

    		NF-κB Fungal Interleukin Related Infection Cancer
    6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44 +/CD24 − breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot .
    6-Methoxymellein
  • HY-181114
    P-gp-IN-34

    		P-glycoprotein Fungal Infection
    P-gp-IN-34 (compound 4a) is an Mdr1p (Mdr1 pump) inhibitor. P-gp-IN-34 inhibits yeast to hyphal shift in Candida albicans. P-gp-IN-34 can be used for the research of candidiasis .
    P-gp-IN-34

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