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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
legumain-cleavable linker
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "legumain-cleavable linker" in MCE Product Catalog:
Cat. No.: HY-176806
CAS No.: 606967-53-7
Synonyms: Doxorubicin-LNAA-Boc
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Legubicin (Doxorubicin-LNAA-Boc) is a novel conjugate of Doxorubicin (HY-15142A) and a Legumain-cleavable peptide linker. Legubicin is activated by Legumain to release leucine-doxorubicin while sparing normal tissues. Legubicin inhibits tumor cell growth and reduces DNA binding in non-legumain expressing cells. Legubicin completely arrests tumor growth in mice bearing CT26 tumors. Legubicin can be used for the study of colon carcinoma (CRC) .
Cat. No.: HY-176976
CAS No.: 3076725-05-5
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Exatecan-mpGNNG (Compound 10a) is the linker-payload component of an antibody-drug conjugate (ADC). Exatecan-mpGNNG is composed of Exatecan (HY-13631), a potent topoisomerase I inhibitor, and the linker .
Cat. No.: HY-185461
CAS No.: 3108288-42-9
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Mc-Asn-Asn-E104 is a conjugate of E104 (HY-156174) and a legumain-cleavable linker, can be used for the synthesis of E104 ISACs.
Cat. No.: HY-185462
CAS No.: 3059867-76-1
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Research Areas:
Mc-Asn-Asn is a legumain cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Asn-Asn can be used in the synthesis of ADCs.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
