Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
microsomal hydroxylation
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "microsomal hydroxylation" in MCE Product Catalog:
Target:
Research Areas:
Doxylamine succinate is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine succinate is orally active, possessing analgesic and hypnotic activities. Doxylamine succinate enhances the activities of CYP2B, CYP2A, CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine succinate decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine succinate induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine succinate can be used for the research of nausea, allergy, insomnia .
Category:
Other Monoterpenes Terpenoids Other Diseases Plants Umbelliferae Vernonia Schreb. Disease Research Fields
Target:
Target:
Research Areas:
Doxylamine is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine is orally active, possessing analgesic and hypnotic activities. Doxylamine enhances the activities of CYP2B, CYP2A, CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine can be used for the research of nausea, allergy, insomnia .
Research Areas:
Doxylamine succinate (Standard) is the analytical standard of Doxylamine succinate (HY-A0069). This product is intended for research and analytical applications. Doxylamine succinate is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine succinate is orally active, possessing analgesic and hypnotic activities. Doxylamine succinate enhances the activities of CYP2B, CYP2A, CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine succinate decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine succinate induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine succinate can be used for the research of nausea, allergy, insomnia .
Cat. No.: HY-177148
CAS No.: 134867-97-3
Target:
Research Areas:
G256 is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 can be used for research on arrhythmias .
Cat. No.: HY-177148A
CAS No.: 134867-96-2
Target:
Research Areas:
G256 dihydrochloride is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 dihydrochloride undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 dihydrochloride generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 dihydrochloride produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 dihydrochloride can be used for research on arrhythmias .
Cat. No.: HY-A0069AS
CAS No.: 1173020-59-1
Cat. No.: HY-A0069S
CAS No.: 1216840-94-6
Cat. No.: HY-177148B
CAS No.: 136623-15-9
Target:
Research Areas:
(E/Z)-G256 (dihydrochloride) is an isomer of G256 dihydrochloride (HY-177148A). G256 dihydrochloride is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 dihydrochloride undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 dihydrochloride generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 dihydrochloride produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 dihydrochloride can be used for research on arrhythmias .
Cat. No.: HY-W421914
CAS No.: 500-28-7
Target:
Research Areas:
Chlorthion is an organic phosphorothionate insecticide. Chlorthion inhibits liver microsomal hydroxylation of testosterone .
Cat. No.: HY-W040305
CAS No.: 99-30-9
Research Areas:
2,6-Dichloro-4-nitroaniline is an orally active Herbicide, Fungicide and uncoupler. 2,6-Dichloro-4-nitroaniline uncouples oxidative phosphorylation and inhibits electron transport. 2,6-Dichloro-4-nitroaniline induces biphenyl hydroxylase activity in rat liver. 2,6-Dichloro-4-nitroaniline increases the relative liver weight of rats via hepatomegaly without altering their body weight .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
