134867-97-3
Chemical Structure
G256
- CAS No.: 134867-97-3
- Formula:C14H14ClN5
- Molecular Weight:287.75
IUPAC Name: (Z)-2-((2-amino-5-chlorophenyl)(phenyl)methylene)hydrazine-1-carboximidamide
InChIKey: VOMKMECTFJLAPY-UYRXBGFRSA-N
SMILES: N=C(N)N/N=C(C1=CC=CC=C1)\C2=C(N)C=CC(Cl)=C2
Biological Activity: G256 is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 can be used for research on arrhythmias[1].
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G256 | G256 is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 can be used for research on arrhythmias. | |||||||||||||||||||||
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Keywords
