136623-15-9
Chemical Structure
(E/Z)-G256 dihydrochloride
- CAS No.: 136623-15-9
- Formula:C14H16Cl3N5
- Molecular Weight:360.67
IUPAC Name: (Z)-2-((2-amino-5-chlorophenyl)(phenyl)methylene)hydrazine-1-carboximidamide hydrochloride
InChIKey: CFYLXZYRXHKYPX-SJNXHXLPSA-N
SMILES: ClC1=CC=C(C(/C(C2=CC=CC=C2)=N\NC(N)=N)=C1)N.Cl.Cl
Biological Activity: (E/Z)-G256 (dihydrochloride) is an isomer of G256 dihydrochloride (HY-177148A). G256 dihydrochloride is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 dihydrochloride undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 dihydrochloride generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 dihydrochloride produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 dihydrochloride can be used for research on arrhythmias[1].
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(E/Z)-G256 dihydrochloride | (E/Z)-G256 (dihydrochloride) is an isomer of G256 dihydrochloride (HY-177148A). G256 dihydrochloride is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 dihydrochloride undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 dihydrochloride generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 dihydrochloride produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 dihydrochloride can be used for research on arrhythmias. | |||||||||||||||||||||
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Keywords
