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non-hydrolyzable

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128933
    AMP-PNP tetralithium
    3 Publications Verification

    Adenylyl-imidodiphosphate tetralithium

    		 Potassium Channel Metabolic Disease
    AMP-PNP (Adenylyl-imidodiphosphate) tetralithium is a non-hydrolyzable ATP analog. AMP-PNP tetralithium binds to ATP binding sites competely but is not hydrolyzed by enzymes, providing stable experimental conditions for studying ATP-dependent processes. AMP-PNP tetralithium can also be used to study enzyme activity, kinase regulation, DNA/RNA metabolism, ion channel function, and protein complex assembly .
    AMP-PNP tetralithium
  • HY-130777A
    AMP-PNP lithium hydrate
    3 Publications Verification

    Adenylyl imidodiphosphate lithium hydrate

    		 Drug Derivative Metabolic Disease
    AMP-PNP (Adenylyl imidodiphosphate) lithium hydrate is a non-hydrolyzable ATP analog. AMP-PNP lithium hydrate binds to ATP binding sites competely but is not hydrolyzed by enzymes, providing stable experimental conditions for studying ATP-dependent processes. AMP-PNP lithium hydrate can also be used to study enzyme activity, kinase regulation, DNA/RNA metabolism, ion channel function, and protein complex assembly .
    AMP-PNP lithium hydrate
  • HY-137167
    Guanylyl imidodiphosphate lithium

    Gpp(NH)p lithium

    		 Adenylate Cyclase Metabolic Disease
    Guanylyl imidodiphosphate lithium (Gpp (NH) p lithium) is a non-hydrolyzable GTP analog. Guanylyl imidodiphosphate lithium increases adenylate cyclase activity. Guanylyl imidodiphosphate lithium binds to and irreversibly activates G proteins .
    Guanylyl imidodiphosphate lithium
  • HY-134353B
    ADP-β-S trilithium

    Adenosine 5'-β-thiodiphosphate trilithium

    		 P2Y Receptor NF-κB Interleukin Related Caspase Neurological Disease Inflammation/Immunology Cancer
    ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) trilithium is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S trilithium activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S trilithium activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S trilithium can be used in the research of diseases such as inflammation and diabetes .
    ADP-β-S trilithium
  • HY-137683A
    Guanosine 5'-O-2-thiodiphosphate trisodium

    GDPβS trisodium

    		 Adenylate Cyclase Cardiovascular Disease
    Guanosine 5'-O-(2-thiodiphosphate) trisodium (GDPβS trisodium) is a non-hydrolyzable derivative of GDP. Guanosine 5'-O-(2-thiodiphosphate) trisodium acts as an inhibitor of adenylyl cyclase (AC) with a Ki value of 600 nM. In the absence of glutamic-pyruvic transaminase (GPT) in cerebral cortex membranes of rodent models, Guanosine 5'-O-(2-thiodiphosphate) trisodium partially activates AC with an EC50 of 400 nM. Guanosine 5'-O-(2-thiodiphosphate) trisodium prevents norepinephrine-induced nitric oxide release in ventricular myocytes .
    Guanosine 5'-O-2-thiodiphosphate trisodium
  • HY-146081
    CD22 ligand-1

    		CD22 Cancer
    CD22 ligand-1 (compound 12) is a potent and selective CD22 ligand with KD of 0.335, 30.7 µM for hCD22 and MAG, respectively. CD22 ligand-1 has the potential for the research of B-cell related disease .
    CD22 ligand-1
  • HY-157093
    Cytidine, 5′-P,P′,P′′,P′′-tetrahydrogen imidotriphosphate

    		Nucleoside Antimetabolite/Analog Others
    Cytidine, 5′-(P,P′,P′′,P′′-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide .
    Cytidine, 5′-P,P′,P′′,P′′-tetrahydrogen imidotriphosphate
  • HY-157091
    Uridine, 5'-P,P',P'',P''-tetrahydrogen imidotriphosphate

    		Nucleoside Antimetabolite/Analog Others
    Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide that can synthesize RNA oligonucleotides .
    Uridine, 5'-P,P',P'',P''-tetrahydrogen imidotriphosphate
  • HY-134353A
    ADP-β-S trisodium

    Adenosine 5'-(β-thiodiphosphate) trisodium

    		 Interleukin Related P2Y Receptor NF-κB Caspase Neurological Disease Inflammation/Immunology Cancer
    ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) trilithium is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S trilithium activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S trilithium activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S trilithium can be used in the research of diseases such as inflammation and diabetes .
    ADP-β-S trisodium
  • HY-128041
    alpha-Hydroxy farnesyl phosphonic acid

    Hydroxyfarnesyl phosphate

    		 Farnesyl Transferase Others
    α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.
    alpha-Hydroxy farnesyl phosphonic acid
  • HY-118556
    Prostaglandin E2 serinol amide

    		Prostaglandin Receptor Endocrinology
    Prostaglandin E2 serinol amide is a weak inhibitor of the hydrolysis of [3H]2-oleoylglycerol. Prostaglandin E2 serinol amide is non-hydrolyzable to produce PGE2 and thus cannot inhibit leukotriene B4 biosynthesis, superoxide production, migration and antimicrobial peptide release .
    Prostaglandin E2 serinol amide

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