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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
non-hydrolyzable
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "non-hydrolyzable" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: Adenylyl-imidodiphosphate tetralithium
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AMP-PNP (Adenylyl-imidodiphosphate) tetralithium is a non-hydrolyzable ATP analog. AMP-PNP tetralithium binds to ATP binding sites competely but is not hydrolyzed by enzymes, providing stable experimental conditions for studying ATP-dependent processes. AMP-PNP tetralithium can also be used to study enzyme activity, kinase regulation, DNA/RNA metabolism, ion channel function, and protein complex assembly .
3
3 Cited Publications
Cat. No.: HY-130777A
Purity: ≥94.0%
Synonyms: Adenylyl imidodiphosphate lithium hydrate
Synonyms: Gpp(NH)p lithium
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Guanylyl imidodiphosphate lithium (Gpp (NH) p lithium) is a non-hydrolyzable GTP analog. Guanylyl imidodiphosphate lithium increases adenylate cyclase activity. Guanylyl imidodiphosphate lithium binds to and irreversibly activates G proteins .
Synonyms: Adenosine 5'-β-thiodiphosphate trilithium
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ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) trilithium is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S trilithium activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S trilithium activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S trilithium can be used in the research of diseases such as inflammation and diabetes .
Cat. No.: HY-137683A
Synonyms: GDPβS trisodium
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Guanosine 5'-O-(2-thiodiphosphate) trisodium (GDPβS trisodium) is a non-hydrolyzable derivative of GDP. Guanosine 5'-O-(2-thiodiphosphate) trisodium acts as an inhibitor of adenylyl cyclase (AC) with a Ki value of 600 nM. In the absence of glutamic-pyruvic transaminase (GPT) in cerebral cortex membranes of rodent models, Guanosine 5'-O-(2-thiodiphosphate) trisodium partially activates AC with an EC50 of 400 nM. Guanosine 5'-O-(2-thiodiphosphate) trisodium prevents norepinephrine-induced nitric oxide release in ventricular myocytes .
Cat. No.: HY-157093
CAS No.: 497064-76-3
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Cytidine, 5′-(P,P′,P′′,P′′-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide .
Cat. No.: HY-157091
CAS No.: 497064-75-2
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Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide that can synthesize RNA oligonucleotides .
Cat. No.: HY-134353A
Synonyms: Adenosine 5'-(β-thiodiphosphate) trisodium
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ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) trilithium is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S trilithium activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S trilithium activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S trilithium can be used in the research of diseases such as inflammation and diabetes .
Cat. No.: HY-128041
CAS No.: 148796-53-6
Synonyms: Hydroxyfarnesyl phosphate
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α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.
Cat. No.: HY-118556
CAS No.: 951209-67-9
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Prostaglandin E2 serinol amide is a weak inhibitor of the hydrolysis of [3H]2-oleoylglycerol. Prostaglandin E2 serinol amide is non-hydrolyzable to produce PGE2 and thus cannot inhibit leukotriene B4 biosynthesis, superoxide production, migration and antimicrobial peptide release .
Cat. No.: HY-184840
CAS No.: 43064-23-9
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(2-Sulfanylethyl)phosphonic acid (compound 2) is a thiol-containing alkylphosphonic acid inhibitor of purple acid phosphatase (PAP), which inhibits PAP derived from red kidney beans with an IC50 of 3000 μM. The phosphonic acid group of (2-Sulfanylethyl)phosphonic acid acts as a non-hydrolyzable phosphate substrate mimic, and the terminal thiol is designed to enhance interactions with the dinuclear metal active center of PAP. (2-Sulfanylethyl)phosphonic acid can be used in studies related to PAP inhibitors and the structure-activity relationships of dinuclear metal phosphatase inhibition .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
