AMP-PNP lithium hydrate
Based on 1 publication(s) in Google Scholar
AMP-PNP (Adenylyl imidodiphosphate) lithium hydrate is a non-hydrolyzable ATP analog. AMP-PNP lithium hydrate binds to ATP binding sites competely but is not hydrolyzed by enzymes, providing stable experimental conditions for studying ATP-dependent processes. AMP-PNP lithium hydrate can also be used to study enzyme activity, kinase regulation, DNA/RNA metabolism, ion channel function, and protein complex assembly.
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- Pureté : 99.98%
- Formule: C10H17N6O12P3·xLi·yH2O
- Masse moléculaire:506.20 (free acid)
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) AMP-PNP lithium hydrate
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Activité biologique
Description
In Vitro
AMP-PNP lithium hydrate (100 nM-3.3 mM) competitively elutes BtuCD(EQNC)-F from ATP-agarose beads, inhibiting the ATPase activity of both wild-type and mutant BtuCD-F[1].
AMP-PNP lithium hydrate (1.9-2 mM, 0-15 min) fails to inhibit the ATP-dependent scanning process of the 5' leader sequence of eukaryotic mRNA[2].
AMP-PNP lithium hydrate (1 μM-1 mM) concentration-dependently blocked the single ATP-sensitive potassium channels (KATP channels) in the skeletal muscles of mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Masse moléculaire 506.20 (free acid)
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Formule C10H17N6O12P3·xLi·yH2O
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Color White to light yellow
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(NP(O)(O)=O)(O)=O)(O)=O.[x].[Li].[y].O
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Synonyms
Adenylyl imidodiphosphate lithium hydrate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Cell
2025 Mar 20;85(6):1176-1188.e5. PMID: 40010342
Solvant et solubilité
In Vitro:
H2O : 50 mg/mL (Need ultrasonic and warming)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Korkhov VM, et al. Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F. Nature. 2012 Oct 18;490(7420):367-72. [Content Brief]
[2]. Sakharov PA, et al. Nonhydrolyzable ATP analog 5'-adenylyl-imidodiphosphate (AMP-PNP) does not inhibit ATP-dependent scanning of leader sequence of mRNA. Biochemistry (Mosc). 2015 Jan;80(1):45-9. [Content Brief]
[3]. Ellinghaus TL, et al. Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Sci Adv. 2021 Dec 24;7(52):eabk2392. [Content Brief]
[4]. Hehl S, Neumcke B. KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur Biophys J. 1994;23(4):231-7. [Content Brief]
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