72957-42-7
Chemical Structure
AMP-PNP tetralithium
Synonym(s): Adenylyl-imidodiphosphate tetralithium
- CAS No.: 72957-42-7
- Formula:C10H13Li4N6O12P3
- Molecular Weight:529.93
InChIKey: FDBDJIGGLGUOPP-KWIZKVQNSA-J
SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(N)=NC=N3)O[C@@H]([C@H]1O)COP(OP(NP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
Biological Activity: AMP-PNP (Adenylyl-imidodiphosphate) tetralithium is a non-hydrolyzable ATP analog. AMP-PNP tetralithium binds to ATP binding sites competely but is not hydrolyzed by enzymes, providing stable experimental conditions for studying ATP-dependent processes. AMP-PNP tetralithium can also be used to study enzyme activity, kinase regulation, DNA/RNA metabolism, ion channel function, and protein complex assembly[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AMP-PNP tetralithium | 99.92% | AMP-PNP (Adenylyl-imidodiphosphate) tetralithium is a non-hydrolyzable ATP analog. AMP-PNP tetralithium binds to ATP binding sites competely but is not hydrolyzed by enzymes, providing stable experimental conditions for studying ATP-dependent processes. AMP-PNP tetralithium can also be used to study enzyme activity, kinase regulation, DNA/RNA metabolism, ion channel function, and protein complex assembly. | ||||||||||||||||||||
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References
- [1]. Korkhov VM, et al. Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F. Nature. 2012 Oct 18;490(7420):367-72. [Content Brief]
- [2]. Sakharov PA, et al. Nonhydrolyzable ATP analog 5'-adenylyl-imidodiphosphate (AMP-PNP tetralithium) does not inhibit ATP-dependent scanning of leader sequence of mRNA. Biochemistry (Mosc). 2015 Jan;80(1):45-9. [Content Brief]
- [3]. Ellinghaus TL, et al. Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Sci Adv. 2021 Dec 24;7(52):eabk2392. [Content Brief]
- [4]. Hehl S, Neumcke B. KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP tetralithium. Eur Biophys J. 1994;23(4):231-7. [Content Brief]
