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Cat. No.: HY-184840

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(2-Sulfanylethyl)phosphonic acid

(2-Sulfanylethyl)phosphonic acid (compound 2) is a thiol-containing alkylphosphonic acid inhibitor of purple acid phosphatase (PAP), which inhibits PAP derived from red kidney beans with an IC₅₀ of 3000 μM. The phosphonic acid group of (2-Sulfanylethyl)phosphonic acid acts as a non-hydrolyzable phosphate substrate mimic, and the terminal thiol is designed to enhance interactions with the dinuclear metal active center of PAP. (2-Sulfanylethyl)phosphonic acid can be used in studies related to PAP inhibitors and the structure-activity relationships of dinuclear metal phosphatase inhibition.

For research use only. We do not sell to patients.

CAS No.: 43064-23-9
Formula: C₂H₇O₃PS
Molecular Weight:142.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(2-Sulfanylethyl)phosphonic acid Chemical Structure

CAS No.: 43064-23-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

Purple acid phosphatase

3000 μM (IC₅₀, red kidney bean)

In Vitro

(2-Sulfanylethyl)phosphonic acid (compound 2) inhibits purple acid phosphatase from red kidney beans with an IC₅₀ of 3000 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 43064-23-9
Molecular Weight 142.11
Formula C₂H₇O₃PS
SMILES

O=P(O)(CCS)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. McGeary RP, et al. The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-β-lactamases and arginases. European journal of medicinal chemistry. 2014 Apr 09;76:132-44. [Content Brief]

[2]. Myers JK, et al. Motifs for Metallophosphatase Inhibition. Journal of the American Chemical Society. 1997;119(13):3163-3164.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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