Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
77 Results for "
plasma protein binding
" in MedChemExpress (MCE) Product Catalog:
Products (77)
77 Results for "plasma protein binding" in MCE Product Catalog:
5
5 Cited Publications
Target:
Research Areas:
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding .
LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .
2
Zotiraciclib (TG02; SB1317) is an orally active JAK2/FLT3/CDK2 inhibitor with IC50 values of 13 nM, 73 nM and 56 nM , respectively. Zotiraciclib inhibits cancer cell proliferation, tumor growth and the activity of CYP2D6. Zotiraciclib exhibits high plasma protein binding rate, Caco-2 permeability and tissue distribution capacity, as well as metabolic stability in human and canine liver microsomes. Zotiraciclib achieves tumor growth inhibition in nude mouse models of colon cancer and lymphoma xenografts. Zotiraciclib can be used for research related to colon cancer, B-cell lymphoma, advanced leukemia, acute leukemia and multiple myeloma .
2
2 Cited Publications
Cat. No.: HY-P70832
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HABP2; Factor VII Activating protein; Hyaluronan binding protein 2; Hyaluronan-binding protein 2; HGFAL; FVII Activator; PHBP; PHBSP; FSAP; Hyaluronic Acid binding protein 2; HABP; plasma Hyaluronan-binding protein; Hepatocyte Growth Factor Activator-Like
1
1 Cited Publications
Research Areas:
OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression .
1
1 Cited Publications
Research Areas:
N-Desmethyl-Apalutamide, the major active metabolite of Apalutamide (HY-16060), is a selective competitive inhibitor of androgen receptor. N-Desmethyl-Apalutamide is catalyzed by CYP3A4 and CYP2C8 enzymes. The plasma protein binding rate of N-Desmethyl-Apalutamide reaches 95%, with albumin as the primary binding protein. N-Desmethyl-Apalutamide is suitable for prostate cancer-related research .
1
1 Cited Publications
Cat. No.: HY-P72031
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RBP4; Retinol-binding protein 4, Interstitial; Retinol binding protein 4; Retinol-binding protein 4, plasma; plasma Retinol-binding protein; Retinol binding protein 4, plasma; Retinol-binding protein 4; Retinol-binding protein; PRBP; MCOPCB10; RBP; RDCCAS
1
1 Cited Publications
Cat. No.: HY-P74598
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: RBP4; Retinol-binding protein 4, Interstitial; Retinol binding protein 4; Retinol-binding protein 4, plasma; plasma Retinol-binding protein; Retinol binding protein 4, plasma; Retinol-binding protein 4; Retinol-binding protein; PRBP; MCOPCB10; RBP; RDCCAS
Target:
Cat. No.: HY-NP002L
Synonyms: Canine Serum Albumin
Cat. No.: HY-P10502
CAS No.: 2378836-93-0
Synonyms: (R)-VX-445
Target:
Research Areas:
(R)-Elexacaftor ((R)-VX-445) is the enantiomer of Elexacaftor (HY-111772). Elexacaftor is an orally active CFTR modulator that targets nucleotide-binding domain 1. Elexacaftor stabilizes misfolded F508del-CFTR protein, enhances its trafficking to the plasma membrane, and significantly improves metabolic stability, thermal stability and ion conductivity. Elexacaftor not only restores chloride transport function in nasal epithelial cells and rescues multiple CFTR mutation subtypes, but also exerts multiplicative synergistic effects with Ivacaftor (HY-13017), and is often used in a triple combination therapy with Tezacaftor (HY-15448). Elexacaftor is widely used in basic and clinical translational research on cystic fibrosis .
Cat. No.: HY-P10502A
Cat. No.: HY-NP180
Cat. No.: HY-NP002K
Synonyms: Rat Serum Albumin
Cat. No.: HY-P991629
Target:
Research Areas:
Cat. No.: HY-P4856
CAS No.: 120298-73-9
Research Areas:
Cat. No.: HY-P10383
CAS No.: 1621616-13-4
Target:
Research Areas:
Cat. No.: HY-178794
CAS No.: 3038861-75-2
Target:
Research Areas:
AGU661 is a Microsomal prostaglandin E2 synthase 1 (mPGES-1) inhibitor with an IC50 of 0.22 nM. AGU661 lowers PGE2 formation in human pro-inflammatory M1 macrophages and activated monocytes without affecting other lipid mediator pathways. AGU661 has unfavorable physicochemical properties with poor metabolic stability and strong plasma protein binding tendencies. AGU661 into PLGA-based NPs significantly enhances its bioactivity. AGU661 can be used for inflammatory disorders research .
Cat. No.: HY-E70696
EGFR is a driver of tumorigenesis. EGFR is mainly found in an auto-inhibited, dimerization-incompetent, state at the plasma membrane (PM). Ligand binding promotes receptor dimerization, which determines a series of structural rearrangements that are conveyed to the cytoplasmic domain allowing the formation of asymmetric dimers between the two juxtaposed catalytic domains. EGFR has multiple mutants. EGFR C797S/L858R Recombinant Human Active Protein Kinase is a recombinant EGFR C797S/L858R protein that can be used to study EGFR C797S/L858R-related functions .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
