186 Results for "

polypeptide receptor

" in MedChemExpress (MCE) Product Catalog:
Products (186)

186 Results for "polypeptide receptor" in MCE Product Catalog:

25
25 Publications Verification
Cat. No.: HY-P1731C
Synonyms: LY3298176 sodium
Tirzepatide sodium (LY3298176 sodium) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide sodium exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide sodium can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity .
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5
5 Cited Publications
Cat. No.: HY-B0804
CAS No.: 42200-33-9
Synonyms: SQ-11725
Target:  

Adrenergic Receptor

Research Areas:  

Cardiovascular Disease

Nadolol (SQ-11725) is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research .
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3
3 Cited Publications
Cat. No.: HY-P3506
CAS No.: 2381089-83-2
Synonyms: LY3437943
Target:  

GCGR GLP Receptor

Research Areas:  

Metabolic Disease

Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity .
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3
3 Cited Publications
Cat. No.: HY-P10138
CAS No.: 1884226-05-4
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

Human GIP(3-30), amide is a high affinity antagonist of the human GIP receptor in vitro. Human GIP(3-30), amide has potential anti-obesity and anti-diabetic effects .
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3
3 Cited Publications
Cat. No.: HY-P3506A
Synonyms: LY3437943 TFA
Target:  

GLP Receptor GCGR

Research Areas:  

Metabolic Disease

Retatrutide (LY3437943) TFA is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide TFA binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide TFA can be used for the research of obesity .
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3
3 Cited Publications
Cat. No.: HY-P10138A
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

Human GIP(3-30), amide TFA is the TFA salt form of human GIP(3-30), amide (HY-P10138). Human GIP(3-30), amide TFA is a high affinity antagonist of the human GIP receptor in vitro. Human GIP(3-30), amide TFA has potential anti-obesity and anti-diabetic effects .
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3
3 Cited Publications
Cat. No.: HY-P3506B
Synonyms: LY3437943 acetate
Target:  

GCGR GLP Receptor

Research Areas:  

Metabolic Disease

Retatrutide (LY3437943) acetate is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide acetate can be used for the research of obesity .
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2
2 Cited Publications
Cat. No.: HY-P2537
CAS No.: 229961-08-4
Research Areas:  

Others

Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect .
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1
1 Cited Publications
Cat. No.: HY-147557
CAS No.: 2305204-24-2
Purity:  99.17%
Synonyms: PAC1R antagonist 1
Target:  

PACAP Receptor

Research Areas:  

Neurological Disease

PA-915 (PAC1R antagonist 1) is a potent and orally active antagonist of PAC1 receptor. PA-915 inhibits pituitary adenylate cyclase-activating polypeptide (PACAP)-induced CREB phosphorylation. PA-915 can inhibit PACAP- and nerve injury-induced allodynia. PA-915 can be used for the research of neuropathic pain .
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1
1 Cited Publications
Cat. No.: HY-P0132
CAS No.: 110590-64-2
Synonyms: Laminin Fragment 929-933
Target:  

NO Synthase

Research Areas:  

Cancer

YIGSR (Laminin Fragment 929-933) is a polypeptide that inhibits tumor growth and metastasis of leukemia cells. YIGSR specifically binds to the 67kDa laminin receptor and regulates the expression of eNOS in endothelial cells. YIGSR can be used in leukemia-related research .
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1
1 Cited Publications
Cat. No.: HY-P1072
CAS No.: 87403-73-4
Target:  

CGRP Receptor

PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism .
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1
1 Cited Publications
Cat. No.: HY-P2541A
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

GIP (1-30) amide, porcine TFA is a full glucose-dependent insulinotropic polypeptide (GIP) receptor agonist with high affinity equal to native GIP(1-42) . GIP (1-30) amide, porcine is a weak inhibitor of gastric acid secretion and potent stimulator of insulin.
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1
1 Cited Publications
Cat. No.: HY-P77721A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGAV; Integrin, Alpha V (Vitronectin receptor, Alpha polypeptide, Antigen CD51); Prev. MSK8; Vitronectin receptor; Prev. VNRA; Integrin AlphaVbeta3; Prev. VTNR; Integrin, Alpha V; Vitronectin receptor Subunit Alpha; CD51 Antigen; Integrin Alpha-V; IDNDC
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-P77719
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: ITGAV; Integrin, Alpha V (Vitronectin receptor, Alpha polypeptide, Antigen CD51); Prev. MSK8; Vitronectin receptor; Prev. VNRA; Integrin AlphaVbeta3; Prev. VTNR; Integrin, Alpha V; Vitronectin receptor Subunit Alpha; CD51 Antigen; Integrin Alpha-V; IDNDC
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-P77720
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: ITGAV; Integrin, Alpha V (Vitronectin receptor, Alpha polypeptide, Antigen CD51); Prev. MSK8; Vitronectin receptor; Prev. VNRA; Integrin AlphaVbeta3; Prev. VTNR; Integrin, Alpha V; Vitronectin receptor Subunit Alpha; CD51 Antigen; Integrin Alpha-V; IDNDC
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-P700762
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGAV; Integrin, Alpha V (Vitronectin receptor, Alpha polypeptide, Antigen CD51); Prev. MSK8; Vitronectin receptor; Prev. VNRA; Integrin AlphaVbeta3; Prev. VTNR; Integrin, Alpha V; Vitronectin receptor Subunit Alpha; CD51 Antigen; Integrin Alpha-V; IDNDC
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-P77718
Purity:  ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: ITGA5; Integrin Alpha-F; Prev. FNRA; CDNA FLJ50382, Moderately Similar To Integrin Alpha-5; CD49e; Very Late Activation Protein 5, Alpha Subunit; Integrin, Alpha 5 (Fibronectin receptor, Alpha polypeptide); Fibronectin receptor, Alpha Subunit; Fibronectin
Species:  
Source:  
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Cat. No.: HY-P2542
CAS No.: 1802086-25-4
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

GIP (3-42), human acts as a glucose-dependent insulinotropic polypeptide (GIP) receptor antagonist, moderating the insulin secreting and metabolic actions of GIP in vivo .
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Cat. No.: HY-P10959
CAS No.: 2923558-68-1
Synonyms: LY3532226
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

Macupatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. Macupatide improves insulin secretion responses and insulin sensitivity.Macupatide can be used for the research of type 2 diabetes .
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Cat. No.: HY-P990047
CAS No.: 2761478-99-1
Synonyms: AMG133 antibody

Research Areas:  

Metabolic Disease

Maridebart (AMG133 antibody) is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody. Maridebart is the antibody portion of Maridebart cafraglutide (HY-164535) and can be used for the synthesis of antibody-drug conjugates (ADC). Maridebart can be used for the reserrch of obesity and type 2 diabetes .
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