110590-64-2
Chemical Structure
YIGSR
Synonym(s): Laminin Fragment 929-933
- CAS No.: 110590-64-2
- Formula:C26H42N8O8
- Molecular Weight:594.66
IUPAC Name: L-tyrosyl-L-isoleucylglycyl-L-seryl-L-arginine
InChIKey: MWOGMBZGFFZBMK-LJZWMIMPSA-N
SMILES: N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CO)NC(CNC([C@H]([C@@H](C)CC)NC([C@H](CC1=CC=C(C=C1)O)N)=O)=O)=O)=O
Biological Activity: YIGSR (Laminin Fragment 929-933) is a polypeptide that inhibits tumor growth and metastasis of leukemia cells. YIGSR specifically binds to the 67kDa laminin receptor and regulates the expression of eNOS in endothelial cells. YIGSR can be used in leukemia-related research[1][2].
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YIGSR | 99.38% | YIGSR (Laminin Fragment 929-933) is a polypeptide that inhibits tumor growth and metastasis of leukemia cells. YIGSR specifically binds to the 67kDa laminin receptor and regulates the expression of eNOS in endothelial cells. YIGSR can be used in leukemia-related research. | ||||||||||||||||||||
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- [1]. Gloe T, et al. The 67-kDa laminin-binding protein is involved in shear stress-dependent endothelial nitric-oxide synthase expression. J Biol Chem. 1999;274(23):15996-16002. [Content Brief]
- [2]. N Yoshida, et al. The laminin-derived peptide YIGSR (Tyr–Ile–Gly–Ser–Arg) inhibits human pre-B leukaemic cell growth and dissemination to organs in SCID mice. Br J Cancer. 1999 Aug; 80(12): 1898–1904. [Content Brief]
Keywords
