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Cat. No.: HY-P11754

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YIGSRC

YIGSRC is a laminin-mimetic peptide. YIGSRC supports endothelial cell adhesion and tube formation. YIGSRC contains a cysteine residue for chemical modification to hydrogels via thiol-ene reaction. YIGSRC can be chemically modified onto hydrogels to improve in vitro vascularization.

For research use only. We do not sell to patients.

CAS No.: 123946-91-8
Formula: C₂₉H₄₇N₉O₉S
Molecular Weight:697.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

YIGSRC Chemical Structure

CAS No.: 123946-91-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

YIGSRC peptide (1.25 mM; 24 h) enhances spreading and tubular structure formation of human umbilical vein endothelial cells in non-porous hydrogels, increasing the HUVEC area relative to unmodified hydrogels^[1].
YIGSRC peptide (1.25 mM; 24 h) causes a minor, statistically significant increase in the area of human umbilical vein endothelial cells in microfiber network hydrogels, though the hydrogel's porous microstructure has a more dominant effect on cellular spreading^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 123946-91-8
Molecular Weight 697.80
Formula C₂₉H₄₇N₉O₉S
SMILES

O=C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)[C@H](CC1=CC=C(C=C1)O)N
Sequence

Tyr-Ile-Gly-Ser-Arg-Cys
Sequence Shortening

YIGSRC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nishiguchi A, et al. Development of Phase-Separating Microfiber Network Hydrogels to Promote In Vitro Vascularization. Biomacromolecules. 2024;25(9):6146-6154. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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