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Results for "

potentiator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (1) Aldose Reductase (2) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (4) Antifolate (1) Autophagy (8) Bacterial (10) Beta-lactamase (2) Calcium Channel (1) CFTR (18) Chloride Channel (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug Derivative (1) Drug Intermediate (1) Endogenous Metabolite (1) Epigenetic Reader Domain (2) Fungal (1) GABA Receptor (4) iGluR (13) Insecticide (1) Isotope-Labeled Compounds (4) mAChR (2) mGluR (4) Microtubule/Tubulin (1) nAChR (2) NF-κB (3) NKCC (1) NOD-like Receptor (NLR) (1) Opioid Receptor (1) p38 MAPK (1) PKC (1) Ras (1) Reference Standards (4) TGF-β Receptor (1) Toll-like Receptor (TLR) (1) Trk Receptor (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (2) Endocrinology (8) Infection (13) Inflammation/Immunology (14) Metabolic Disease (2) Neurological Disease (30)

By Targets:

17β-HSD (1)

Aldose Reductase (2)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (4)

Antifolate (1)

Autophagy (8)

Bacterial (10)

Beta-lactamase (2)

Calcium Channel (1)

CFTR (18)

Chloride Channel (1)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (1)

Dopamine Receptor (1)

Drug Derivative (1)

Drug Intermediate (1)

Endogenous Metabolite (1)

Epigenetic Reader Domain (2)

Fungal (1)

GABA Receptor (4)

iGluR (13)

Insecticide (1)

Isotope-Labeled Compounds (4)

mAChR (2)

mGluR (4)

Microtubule/Tubulin (1)

nAChR (2)

NF-κB (3)

NKCC (1)

NOD-like Receptor (NLR) (1)

Opioid Receptor (1)

p38 MAPK (1)

PKC (1)

Ras (1)

Reference Standards (4)

TGF-β Receptor (1)

Toll-like Receptor (TLR) (1)

Trk Receptor (1)

By Research Areas:

Cancer (17)

Cardiovascular Disease (2)

Endocrinology (8)

Infection (13)

Inflammation/Immunology (14)

Metabolic Disease (2)

Neurological Disease (30)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13017

Ivacaftor Maximum Cited Publications 27 Publications Verification VX-770	CFTR Autophagy	Endocrinology
Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively.

HY-15448

Tezacaftor 20+ Cited Publications VX-661	CFTR	Cancer
Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-13667

Levoleucovorin Calcium 3 Publications Verification Calcium levofolinate; CL307782	Antifolate	Cancer
Levoleucovorin Calcium (Calcium levofolinate) is the active form of calcium Folinic acid (HY-13664) and has anti-tumor effects. Levoleucovorin Calcium is also a potentiator of the anti-cancer toxicity of 5-Fluorouracil (HY-90006) .

HY-108450

Polygodial 1 Publications Verification Poligodial; Tadeonal	Fungal	Infection Inflammation/Immunology
Polygodial (Poligodial) is an antifungal potentiator . Polygodial is a sesquiterpene with anti-hyperalgesic properties .

HY-P1649

SPR741 3 Publications Verification NAB741	Bacterial Antibiotic	Infection
SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 .

HY-111099

GLPG1837 2 Publications Verification ABBV-974	CFTR Autophagy	Others
GLPG1837 is a potent and reversible CFTR potentiator, with EC₅₀s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.

HY-107701

CGP 78608 hydrochloride	iGluR	Neurological Disease
CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC₅₀ of 6 nM. CGP 78608 hydrochloride acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC₅₀ in the low nM range (26.3 nM). Anticonvulsant activity .

HY-P1649B

SPR741 acetate 3 Publications Verification NAB741 acetate	Bacterial Antibiotic	Infection
SPR741 acetate (NAB741 acetate) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 acetate increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 acetate inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 acetate .

HY-10934

Mibampator LY451395	iGluR	Neurological Disease
Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.

HY-18699

CIQ 2 Publications Verification	iGluR	Neurological Disease
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit.

HY-12509

PEPA	iGluR	Neurological Disease
PEPA is an AMPA receptor allosteric potentiator. PEPA shows preferential action of PEPA on the flop form of AMPA receptors. PEPA is a more potent suppressor of desensitization of receptors containing GluR3 and GluR4 as opposed to those containing GluR1. PEPA has antianxiety effects .

HY-171844

CX1739	iGluR	Neurological Disease Inflammation/Immunology
CX1739 is an orally active, blood-brain barrier permeable, low-efficacy AMPA-glutamate receptor (AMPAR) potentiator. CX1739 enhances excitatory neurotransmission by potentiating glutamate-induced excitatory currents and promoting in vivo long-term potentiation. CX1739 eliminates amphetamine-induced locomotor activity, reverses opioid-, pentobarbital- and ethanol-induced respiratory depression, and exerts pro-cognitive effects in animals. CX1739 impairs motor function recovery and increases the risk of post-injury complications. CX1739 can be used in research related to attention-deficit/hyperactivity disorder, dementia, respiratory depression and spinal cord injury .

HY-169929

KCC2 potentiators-1	NKCC	Neurological Disease
KCC2 potentiators-1 (Compound 2) is a Potassium chloride cotransporter-2 (KCC2) potentiator. KCC2 potentiators-1 is promising for research of neurological disorder .

HY-109177

Icenticaftor QBW251	CFTR	Inflammation/Immunology
Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC₅₀s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research .

HY-123068

Captopril disulfide SQ 14551	Drug Derivative	Cardiovascular Disease
Captopril disulfide (SQ 14551) is an orally active disulfide dimer prodrug. Captopril disulfide is metabolized to Captopril and acts as a Bradykinin potentiator. Captopril disulfide enhances the vasodilatory effect of Bradykinin in anesthetized rats and the contractile response of isolated guinea pig ileum to Bradykinin. Captopril disulfide exhibits antihypertensive activity in spontaneously hypertensive rats. Captopril disulfide can be used in hypertension-related research .

HY-N9517

QS 7 QS 7 Api	Others	Inflammation/Immunology Cancer
QS 7 (QS 7 Api) is a triterpene saponin found in the bark of Quillaja saponaria and immune adjuvant with immune response potentiator activity. QS 7 can be used as vaccine adjuvant for the research of antitumor and antiviral vaccine development .

HY-112781

Pesampator PF-04958242	iGluR	Neurological Disease
Pesampator (PF-04958242) is a potent and highly selective positive allosteric modulator of AMPA receptor (an AMPA potentiator) with an EC₅₀ of 310 nM and a K_i of 170 nM .

HY-119936

GLPG2451	CFTR Autophagy	Inflammation/Immunology
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC₅₀ of 11.1 nM .

HY-122742

HBT1	iGluR	Neurological Disease
HBT1 is an effective AMPA receptor AMPA-R potentiator. HBT1 specifically binds to the ligand-binding domain (LBD) of AMPAR and enhances receptor activity only when AMPA is present., HBT1 has almost no agonistic effect (i.e., reaching the optimal concentration, and then the efficacy decreases as the concentration continues to increase) compared with traditional AMPA-R potentiator, avoiding the bell-shaped reaction of brain-derived neurotrophic factor (BDNF) production in primary neurons. HBT1 can be applicable to a wider range of neurological and psychiatric diseases (such as depression, Alzheimer's disease, etc.) .

HY-13017S2

Ivacaftor-d18 VX-770-d₁₈	Autophagy CFTR	Endocrinology
Ivacaftor-d₁₈ is the deuterium labeled Ivacaftor . Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively .

HY-115553

DETQ	Dopamine Receptor	Neurological Disease
DETQ is a selective, allosteric and orally active dopamine D1 receptor (Dopamine Receptor) potentiator. In HEK293 cells expressing the human D1 receptor, DETQ increases cAMP with an EC₅₀ of 5.8 nM and a K_b of 26 nM. DETQ shows ~30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor .

HY-158991

I1421	CFTR	Inflammation/Immunology
I1421 is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 of 64 nM for WT CFTR currents. I1421 also allosterically activates multiple mutants causing cystic fibrosis (CF) with good in vivo potency, with an oral bioavailability of 60% in mice corresponding to a half-life of 75 min. I1421 synergizes with Elexacaftor (HY-111772) to enhance CFTR currents .

HY-P3985

*Bradykinin potentiator* B** Bradykinin potentiating peptide B	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Others
Bradykinin potentiator B (Bradykinin potentiating peptide B) is venom of Agkistrodon halys blomhoffi. Bradykinin potentiator B is a potent ACE inhibitor. Bradykinin potentiator inhibits the activity of bradykinin inhibitory peptidase .

HY-10935

LY450108 1 Publications Verification	iGluR	Neurological Disease
LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research .

HY-13017S3

Ivacaftor-d4 VX-770-d₄	CFTR	Endocrinology
Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor (HY-13017). Ivacaftor is a potent and orally active CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively .

HY-117517

NG-012	Trk Receptor	Cancer
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

HY-136939

CFTR corrector 6	CFTR	Metabolic Disease Inflammation/Immunology
CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research .

HY-134598A

653-47 hydrochloride	Epigenetic Reader Domain	Cancer
653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC₅₀ of 26.3 μM .

HY-177552

4''-Oxoavermectin B1a	GABA Receptor Chloride Channel Insecticide	Infection
4''-Oxoavermectin B1a is a potentiator targeting GABA (γ-aminobutyric acid) and glutamate-gated chloride channels with insecticidal and acaricidal activities. 4''-Oxoavermectin B1a is promising for research of agricultural pests .

HY-107508

VU-29	mGluR	Neurological Disease
VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor (EC₅₀=9 nM and K_i=244 nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC₅₀: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM) .

HY-14563

VU10010	mAChR	Neurological Disease
VU10010 is a potent, highly selective and allosteric M₄ mAChR potentiator with an EC₅₀ of 400 nM. VU10010 binds to an allosteric site on M₄ mAChR and increases affinity for acetylcholine and coupling to G proteins. VU10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus .

HY-P3991

*Bradykinin potentiator* C**	Angiotensin-converting Enzyme (ACE)	Metabolic Disease
Bradykinin potentiator C is a potent angiotensin-converting enzyme (ACE) inhibitor with an IC₅₀ of 7.1 μM for rabbit lung ACE. Bradykinin potentiator C is a postulated prototype of functional peptide .

HY-103369

PG01	CFTR	Endocrinology
PG01 is a potent CFTR Cl ^- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with K_d values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (K_a of 0.3 μM). PG01 increases ΔF508-CFTR Cl ^- current after adding Forskolin .

HY-13017B

Ivacaftor hydrate VX-770 hydrate	CFTR Autophagy	Endocrinology
Ivacaftor hydrate (VX-770 hydrate) is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.

HY-145126

CP-628006	CFTR	Inflammation/Immunology
CP-628006, a small molecule CFTR potentiator, restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR.

HY-15442

Biphenylindanone A BINA	mGluR	Neurological Disease
Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders .

HY-161839

AKR1C2/3-IN-1	Aldose Reductase	Cancer
AKR1C2/3-IN-1 (compound 3a) is a potent AKR1C2 and AKR1C3 inhibitor with IC₅₀ values of 90, 50 nM, respectively. AKR1C2/3-IN-1 can be used as a radiation sensitizer and as a potentiator of chemotherapy cytotoxicity .

HY-161753

*CFTR potentiator* 1**	CFTR	Inflammation/Immunology
CFTR potentiator 1 (I1421) is a potent CFTR potentiator with an EC₅₀ value of 64 nM. CFTR potentiator 1 allosterically activates a wide range of CF-causing mutants, such as ΔF508 and G551D CFTR .

HY-P3129

KRAS G13D peptide, 25 mer	Ras	Inflammation/Immunology Cancer
KRAS G13D peptide, 25 mer, a KRAS activating oncogene mutation peptide, is an immune potentiator extracted from patent WO2018144775A1. KRAS G13D peptide, 25 mer can be used to prepare KRAS vaccine .

HY-147367

AM-1488	Others	Neurological Disease
AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC₅₀=0.45 μM) .

HY-107683

LY-2087101	nAChR	Neurological Disease
LY-2087101 is an allosteric potentiator of α7 nAChRs. LY-2087101 causes potentiation of agonist-evoked α7 responses by binding within the nAChR transmembrane region .

HY-116152S

Cipepofol-d6 Ciprofol-d₆; HSK3486-d₆	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Cipepofol-d₆ (Ciprofol-d₆; HSK3486-d₆) is deuterium labeled Cipepofol (HY-116152). Cipepofol (HSK3486), a psychomotor stabilizing agent, is a gamma-aminobutyric acid (GABA) receptor potentiator.

HY-147352

*NMDA receptor potentiator-1*	iGluR	Neurological Disease
NMDA receptor potentiator-1 (Compound 1368) is a subunit selective NMDA receptor potentiator with IC₅₀s of 4 μM and 5 μM against NR2C and NR2D expression, respectively .

HY-120811

PF-04701475	iGluR	Neurological Disease
PF-04701475 is a potent AMPA receptor potentiator with an EC₅₀ of 123 nM. PF-04701475 can be used for the study of neurological disorders .

HY-149861

Mip-IN-1	Bacterial	Infection
Mip-IN-1（S,S-28i）is a new rapamycin-derived macrophage infectivity potentiator (Mip) inhibitor. Mip-IN-1 displays strong anti-enzymatic activity against the Mip proteins of Neisseria meningitidis and Neisseria gonorrhoeae and substantially improved the ability of macrophages to kill the bacteria .

HY-P1649A

SPR741 TFA NAB741 TFA	Bacterial Antibiotic	Infection
SPR741 TFA (NAB741 TFA) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 TFA increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 TFA inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 TFA .

HY-13017A

Ivacaftor benzenesulfonate VX-770 benzenesulfonate	CFTR Autophagy	Endocrinology
Ivacaftor benzenesulfonate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.

HY-169193

Azocarnil	GABA Receptor	Neurological Disease
Azocarnil is a GABAergic agonist-potentiator. Azocarnil can be used in neurological research .

HY-139715

IMD-ferulic	NF-κB	Cancer
IMD-ferulic is a covalently linked NF-κB modulator that improves the adjuvanticity of small molecule immune potentiators.

HY-139717

IMD-biphenylA	NF-κB	Cancer
IMD-biphenylA is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves the adjuvanticity of small molecule immune potentiators.

Cat. No.	Product Name	Target	Research Area

HY-P1649

SPR741 3 Publications Verification NAB741	Bacterial Antibiotic	Infection
SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 .

HY-P1649B

SPR741 acetate 3 Publications Verification NAB741 acetate	Bacterial Antibiotic	Infection
SPR741 acetate (NAB741 acetate) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 acetate increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 acetate inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 acetate .

HY-P3985

*Bradykinin potentiator* B** Bradykinin potentiating peptide B	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Others
Bradykinin potentiator B (Bradykinin potentiating peptide B) is venom of Agkistrodon halys blomhoffi. Bradykinin potentiator B is a potent ACE inhibitor. Bradykinin potentiator inhibits the activity of bradykinin inhibitory peptidase .

HY-P3991

*Bradykinin potentiator* C**	Angiotensin-converting Enzyme (ACE)	Metabolic Disease
Bradykinin potentiator C is a potent angiotensin-converting enzyme (ACE) inhibitor with an IC₅₀ of 7.1 μM for rabbit lung ACE. Bradykinin potentiator C is a postulated prototype of functional peptide .

HY-P3129

KRAS G13D peptide, 25 mer	Ras	Inflammation/Immunology Cancer
KRAS G13D peptide, 25 mer, a KRAS activating oncogene mutation peptide, is an immune potentiator extracted from patent WO2018144775A1. KRAS G13D peptide, 25 mer can be used to prepare KRAS vaccine .

HY-P1649A

SPR741 TFA NAB741 TFA	Bacterial Antibiotic	Infection
SPR741 TFA (NAB741 TFA) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 TFA increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 TFA inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 TFA .

HY-P11720

M104 peptide	Beta-lactamase Bacterial	Infection
M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48 . M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13667

Levoleucovorin Calcium 3 Publications Verification Calcium levofolinate; CL307782	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Antifolate
Levoleucovorin Calcium (Calcium levofolinate) is the active form of calcium Folinic acid (HY-13664) and has anti-tumor effects. Levoleucovorin Calcium is also a potentiator of the anti-cancer toxicity of 5-Fluorouracil (HY-90006) .

HY-108450

Polygodial 1 Publications Verification Poligodial; Tadeonal	other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Inflammation/Immunology Disease Research Fields Source Classification	Fungal
Polygodial (Poligodial) is an antifungal potentiator . Polygodial is a sesquiterpene with anti-hyperalgesic properties .

HY-N9517

QS 7 QS 7 Api	Triterpenes Structural Classification Quillajaceae Quillaja saponaria Molina Terpenoids Plants Pentacyclic Triterpenoids Source Classification	Others
QS 7 (QS 7 Api) is a triterpene saponin found in the bark of Quillaja saponaria and immune adjuvant with immune response potentiator activity. QS 7 can be used as vaccine adjuvant for the research of antitumor and antiviral vaccine development .

HY-117517

NG-012	Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification Cancer	Trk Receptor
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

HY-113319R

β-D-Fructose, (Standard)	Structural Classification Endogenous metabolite Saccharides Monosaccharides Source Classification	Reference Standards Drug Intermediate
β-D-Fructose, (Standard) is the analytical standard of β-D-Fructose (HY-113319R). This product is intended for research and analytical applications. β-D-Fructose is a monosaccharide. Derivatives synthesized using β-D-Fructose as the sugar backbone exhibit potent and selective antiproliferative activity against breast cancer MCF-7 cells .

HY-N13170

Glycoside H2	Structural Classification Asclepiadaceae Plants Periploca sepium Bunge Steroids Source Classification	Others
Glycoside H2 is a potentiator of NGF-mediated nerve fiber outgrowth .

HY-N15435

Conimine	Apocynaceae Structural Classification Alkaloids Other Alkaloids Plants Holarrhena antidysenterica Roth Source Classification	Bacterial
Conimine is a steroidal alkaloid, antibacterial agent and potentiator. Conimine is isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Conimine exhibits intrinsic antibacterial activity against methicillin-sensitive *Staphylococcus aureus* and methicillin-resistant *Staphylococcus aureus. When combined with Penicillin, Conimine shows synergistic antibacterial effects against methicillin-resistant Staphylococcus aureus; when combined with Vancomycin (HY-B0671), it exerts synergistic antibacterial effects against both methicillin-sensitive and methicillin-resistant Staphylococcus aureus* .

HY-N17845

3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl	Bletilla striata (Thunb. ex Murray) Rchb. f. Structural Classification Simple Phenylpropanols Orchidaceae Phenylpropanoids Plants Source Classification	Microtubule/Tubulin
3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl, a stilbenoid compound, is a tubulin inhibitor with an IC₅₀ of 10 μM. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl inhibits tubulin polymerization. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl functions as a potentiator that potentiates SN-38 (HY-13704) cytotoxicity in BCRP-transduced cancer cells. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl can be used for the study of breast cancer .

Cat. No.	Product Name	Chemical Structure

HY-13017S2

Ivacaftor-d18
Ivacaftor-d₁₈ is the deuterium labeled Ivacaftor . Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively .

HY-13017S3

Ivacaftor-d4
Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor (HY-13017). Ivacaftor is a potent and orally active CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively .

HY-116152S

Cipepofol-d6
Cipepofol-d₆ (Ciprofol-d₆; HSK3486-d₆) is deuterium labeled Cipepofol (HY-116152). Cipepofol (HSK3486), a psychomotor stabilizing agent, is a gamma-aminobutyric acid (GABA) receptor potentiator.

HY-116152S2

Cipepofol-d6-2
Cipepofol-d₆-2 (Ciprofol-d₆-2; HSK3486-d₆-2) is deuterium labeled Cipepofol (HY-116152). Cipepofol (HSK3486), a psychomotor stabilizing agent, is a gamma-aminobutyric acid (GABA) receptor potentiator.

HY-13017S4

Ivacaftor-13C6
Ivacaftor- ¹³C₆ (VX-770- ¹³C₆) is ¹³C labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively.

HY-15448S1

Tezacaftor-d6

Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

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