64806-05-9
Chemical Structure
Captopril disulfide
Synonym(s): SQ 14551
- CAS No.: 64806-05-9
- Formula:C18H28N2O6S2
- Molecular Weight:432.55
IUPAC Name: (2'S)-((2S,2'S)-3,3'-disulfanediylbis(2-methylpropanoyl))di-L-proline
InChIKey: ZWKRXBCJAUKDCI-MQYQWHSLSA-N
SMILES: O=C([C@@H](CSSC[C@H](C(N1[C@H](C(O)=O)CCC1)=O)C)C)N2[C@H](C(O)=O)CCC2
Biological Activity: Captopril disulfide (SQ 14551) is an orally active disulfide dimer prodrug. Captopril disulfide is metabolized to Captopril and acts as a Bradykinin potentiator. Captopril disulfide enhances the vasodilatory effect of Bradykinin in anesthetized rats and the contractile response of isolated guinea pig ileum to Bradykinin. Captopril disulfide exhibits antihypertensive activity in spontaneously hypertensive rats. Captopril disulfide can be used in hypertension-related research[1][2].
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Captopril disulfide | 99.29% | Captopril disulfide (SQ 14551) is an orally active disulfide dimer prodrug. Captopril disulfide is metabolized to Captopril and acts as a Bradykinin potentiator. Captopril disulfide enhances the vasodilatory effect of Bradykinin in anesthetized rats and the contractile response of isolated guinea pig ileum to Bradykinin. Captopril disulfide exhibits antihypertensive activity in spontaneously hypertensive rats. Captopril disulfide can be used in hypertension-related research. | ||||||||||||||||||||
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Captopril disulfide (Standard) | ≥98% | Captopril disulfide (Standard) is the analytical standard of Captopril disulfide. This product is intended for research and analytical applications. Captopril disulfide is a metabolite of Captopril with antihypertensive activity. | ||||||||||||||||||||
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- [1]. Drummer OH, et al. Captopril disulfide conjugates may act as prodrugs: disposition of the disulfide dimer of captopril in the rat. Biochem Pharmacol. 1984;33(22):3567-3571. [Content Brief]
- [2]. Drummer OH, et al. Bradykinin-potentiating activity of captopril disulphide dimer (SQ 14,551). Eur J Pharmacol. 1988;153(1):11-17. [Content Brief]
