1334546-77-8
1334546-77-8
Chemical Structure
Icenticaftor
Synonym(s): QBW251
- CAS No.: 1334546-77-8
- Formula:C12H13F6N3O3
- Molecular Weight:361.24
IUPAC Name: (S)-3-amino-6-methoxy-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide
InChIKey: USHQRIKZLHNPQR-JTQLQIEISA-N
SMILES: O=C(C1=NC(OC)=C(C(F)(F)F)C=C1N)NC[C@](C)(O)C(F)(F)F
Biological Activity: Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC50s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Icenticaftor | 99.66% | Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC50s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research. | ||||||||||||||||||||
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Icenticaftor (Standard) | ≥98% | Icenticaftor (Standard) is the analytical standard of Icenticaftor (HY-109177). This product is intended for research and analytical applications. Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC50s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research. | ||||||||||||||||||||
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References
Keywords
