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Cat. No.: HY-109177R

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Icenticaftor (Standard)

(Synonyms: QBW251 (Standard))

Icenticaftor (Standard) is the analytical standard of Icenticaftor (HY-109177). This product is intended for research and analytical applications. Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC₅₀s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research.

For research use only. We do not sell to patients.

CAS No.: 1334546-77-8
Formula: C₁₂H₁₃F₆N₃O₃
Molecular Weight:361.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Icenticaftor (Standard) Chemical Structure

CAS No.: 1334546-77-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1334546-77-8
Molecular Weight 361.24
Formula C₁₂H₁₃F₆N₃O₃
SMILES

O=C(C1=NC(OC)=C(C(F)(F)F)C=C1N)NC[C@](C)(O)C(F)(F)F
Synonyms

QBW251 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Darren Le Grand, et al. Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. J Med Chem. 2021 Jun 10;64(11):7241-7260. [Content Brief]

[2]. Steven M Rowe, et al. Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial. Int J Chron Obstruct Pulmon Dis. 2020 Oct 5;15:2399-2409. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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