CGP 78608 hydrochloride
Based on 1 Customer Validation
CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 hydrochloride acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 1135278-54-4
- Formula: C11H14BrClN3O5P
- Molecular Weight:414.58
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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NMDA Receptor |
CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites[2].
CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1135278-54-4
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Appearance Solid
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Molecular Weight 414.58
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Formula C11H14BrClN3O5P
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Color White to off-white
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SMILES
OP(O)([C@H](NCC1=CC(Br)=CC(NC2=O)=C1NC2=O)C)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
1 M NaOH : ≥ 50 mg/mL (120.60 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Catarzi D, et al. Competitive Gly/NMDA receptor antagonists. Curr Top Med Chem. 2006;6(8):809-21. [Content Brief]
[2]. Grand T, et al. Unmasking GluN1/GluN3A excitatory glycine NMDA receptors. Nat Commun. 2018 Nov 13;9(1):4769. [Content Brief]
[3]. Hilgier W, et al. A novel glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia. Brain Res. 2004 Jul 23;1015(1-2):186-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1 M NaOH | 1 mM | 2.4121 mL | 12.0604 mL | 24.1208 mL | 60.3020 mL |
| 5 mM | 0.4824 mL | 2.4121 mL | 4.8242 mL | 12.0604 mL | |
| 10 mM | 0.2412 mL | 1.2060 mL | 2.4121 mL | 6.0302 mL | |
| 15 mM | 0.1608 mL | 0.8040 mL | 1.6081 mL | 4.0201 mL | |
| 20 mM | 0.1206 mL | 0.6030 mL | 1.2060 mL | 3.0151 mL | |
| 25 mM | 0.0965 mL | 0.4824 mL | 0.9648 mL | 2.4121 mL | |
| 30 mM | 0.0804 mL | 0.4020 mL | 0.8040 mL | 2.0101 mL | |
| 40 mM | 0.0603 mL | 0.3015 mL | 0.6030 mL | 1.5075 mL | |
| 50 mM | 0.0482 mL | 0.2412 mL | 0.4824 mL | 1.2060 mL | |
| 60 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0050 mL | |
| 80 mM | 0.0302 mL | 0.1508 mL | 0.3015 mL | 0.7538 mL | |
| 100 mM | 0.0241 mL | 0.1206 mL | 0.2412 mL | 0.6030 mL |
CGP 78608 hydrochloride Related Classifications
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