CGP 78608 hydrochloride
Based on 1 Customer Validation
CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 hydrochloride acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.85%
- CAS No.: 1135278-54-4
- Formule: C11H14BrClN3O5P
- Masse moléculaire:414.58
-
Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-100714A
D-AP5NMDA Antagonist -
HY-15084
Dizocilpine maleateNMDA Antagonist -
HY-100714
DL-AP5NMDA Receptor Antagonist -
HY-N2311
Ibotenic acidiGluR Agonist -
HY-13993
Ro 25-6981NMDAR Antagonist -
HY-100834
5,7-Dichlorokynurenic acidNMDA Receptor Antagonist -
HY-13993A
Ro 25-6981 MaleateNMDAR Antagonist -
HY-N2311R
Ibotenic acid (Standard)iGluR Agonist -
HY-16728
RapastinelNMDAR Modulator -
HY-12881
EliprodilNR2B-NMDA Inhibitor -
HY-13059
SDZ 220-581NMDA Receptor Antagonist -
HY-107711
DQP-1105NMDA Receptor Antagonist
Voir tous les produits spécifiques à Isoform iGluR
More
Activité biologique
Description
IC50 & Target
|
NMDA Receptor |
In Vitro
CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites[2].
CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1135278-54-4
-
Appearance Solid
-
Masse moléculaire 414.58
-
Formule C11H14BrClN3O5P
-
Color White to off-white
-
SMILES
OP(O)([C@H](NCC1=CC(Br)=CC(NC2=O)=C1NC2=O)C)=O.[H]Cl
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
1 M NaOH : ≥ 50 mg/mL (120.60 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
-
Fiche technique (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Catarzi D, et al. Competitive Gly/NMDA receptor antagonists. Curr Top Med Chem. 2006;6(8):809-21. [Content Brief]
[2]. Grand T, et al. Unmasking GluN1/GluN3A excitatory glycine NMDA receptors. Nat Commun. 2018 Nov 13;9(1):4769. [Content Brief]
[3]. Hilgier W, et al. A novel glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia. Brain Res. 2004 Jul 23;1015(1-2):186-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1 M NaOH | 1 mM | 2.4121 mL | 12.0604 mL | 24.1208 mL | 60.3020 mL |
| 5 mM | 0.4824 mL | 2.4121 mL | 4.8242 mL | 12.0604 mL | |
| 10 mM | 0.2412 mL | 1.2060 mL | 2.4121 mL | 6.0302 mL | |
| 15 mM | 0.1608 mL | 0.8040 mL | 1.6081 mL | 4.0201 mL | |
| 20 mM | 0.1206 mL | 0.6030 mL | 1.2060 mL | 3.0151 mL | |
| 25 mM | 0.0965 mL | 0.4824 mL | 0.9648 mL | 2.4121 mL | |
| 30 mM | 0.0804 mL | 0.4020 mL | 0.8040 mL | 2.0101 mL | |
| 40 mM | 0.0603 mL | 0.3015 mL | 0.6030 mL | 1.5075 mL | |
| 50 mM | 0.0482 mL | 0.2412 mL | 0.4824 mL | 1.2060 mL | |
| 60 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0050 mL | |
| 80 mM | 0.0302 mL | 0.1508 mL | 0.3015 mL | 0.7538 mL | |
| 100 mM | 0.0241 mL | 0.1206 mL | 0.2412 mL | 0.6030 mL |
CGP 78608 hydrochloride Related Classifications
HY-107701 Related Classifications
Powered by Bioz