1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. CGP 78608 hydrochloride

CGP 78608 hydrochloride 

Cat. No.: HY-107701
Handling Instructions

CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity.

For research use only. We do not sell to patients.

CGP 78608 hydrochloride Chemical Structure

CGP 78608 hydrochloride Chemical Structure

CAS No. : 1135278-54-4

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Description

CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity[1][2].

In Vitro

CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites[2].
CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity[3].

In Vivo

CGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice[1].

Molecular Weight

414.58

Formula

C₁₁H₁₄BrClN₃O₅P

CAS No.

1135278-54-4

SMILES

OP(O)([[email protected]](NCC1=CC(Br)=CC(NC2=O)=C1NC2=O)C)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CGP 78608CGP78608CGP-78608iGluRIonotropic glutamate receptorsammonia-dependentcGMPsynthesisGlyneurotoxicityanticonvulsantGluN1GluN3AInhibitorinhibitorinhibit

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CGP 78608 hydrochloride
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HY-107701
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