31 Results for "

scFv

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "scFv" in MCE Product Catalog:

Cat. No.: HY-P990688
CAS No.: 2559056-68-5
Synonyms: AMG-509

Target:  

CD3

Research Areas:  

Cancer

Xaluritamig (AMG-509) is a bispecific T cell engager and cytolytic agent with a Kd of 27.6 nM for human CD3ε. Xaluritamig binds to CD3ε via an anti-CD3 single-chain variable fragment (scFv) domain, and to STEAP1 via a bispecific anti-STEAP1 antigen-binding fragment (Fab) domain, thereby recruiting and activating T cells and forming a bridge between T cells and STEAP1-expressing cancer cells. Xaluritamig induces T cell-mediated redirected cytotoxicity, tumor cell lysis, cytokine release, CD8 + T cell activation and expansion, as well as tumor stasis or regression. Xaluritamig contains an Fc domain with no effector function, which prolongs serum half-life, exhibits only minimal activity against cells with low STEAP1 expression and normal cells, and shows extremely low target-related off-tumor toxicity in cynomolgus monkeys. Xaluritamig is used in STEAP1×CD3 XmAb 2+1 immunotherapy and in research on metastatic castration-resistant prostate cancer and Ewing sarcoma .
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Cat. No.: HY-P99521
CAS No.: 2138442-13-2
Synonyms: XmAb14045

Target:  

CD3

Research Areas:  

Inflammation/Immunology Cancer

Vibecotamab (XmAb14045) is a potent bispecific antibody targeting both CD123 and CD3. Vibecotamab targets T cell-mediated killing of CD123-expressing cells, regardless of T cell antigen specificity. Vibecotamab is a full length immunoglobulin molecule. Vibecotamab can be studied in research for diseases such as Myelodysplastic syndrome and acute myeloid leukemia. Recommend Isotype Control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .
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Cat. No.: HY-P990717
CAS No.: 2736407-54-6
Synonyms: IMC-F106C

Target:  

CD3

Research Areas:  

Cancer

Brenetafusp is a TCR/anti-CD3 bispecific fusion protein, consisting of a TCR targeting the PRAME peptide and an anti-CD3 scFv effector domain. Brenetafusp redirects CD3 + T cells to kill PRAME + tumor cells. Brenetafusp can be used in research related to cutaneous melanoma, non-small cell lung cancer, ovarian cancer, endometrial cancer, triple-negative breast cancer, and small cell lung cancer .
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Cat. No.: HY-P990735
CAS No.: 2765066-99-5
Synonyms: UCB-1381

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Donzakimig is a trispecific anti-IL-13/IL-22/HSA antibody. Donzakimig adopts a Fab-scFv-scFv structural format (without an Fc region), in which the Fab domain is linked to the scFv domains via a S (G4S)2 linker. Donzakimig binds to and inhibits the activities of IL-13 and IL-22, thereby blocking the signal transduction of these two cytokines. Donzakimig can extend its serum half-life by binding to human serum albumin, enhancing its in vivo stability and achieving long-acting efficacy. Donzakimig can be used in research on moderate-to-severe atopic dermatitis, moderate-to-severe asthma (especially eosinophilic type), psoriasis, inflammatory bowel disease, and other conditions .
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Cat. No.: HY-P990920
CAS No.: 2851862-91-2
Synonyms: MK-6070; HPN328

Target:  

CD3

Research Areas:  

Cancer

HY-P990920 is an CD3E/ALB/DLL3-targeting (scFv-heavy-lamdba)-VH-VH' type chimeric humanized antibody .
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Cat. No.: HY-P990314

Target:  

EGFR

Research Areas:  

Inflammation/Immunology

AFM24 is a bispecific antibody with a TandAb structure expressed in CHO, targeting EGFR&Fc-gamma-RIIIA. AFM24 contains a huIgG1-SCFV heavy chain and a λ light chain, with a predicted molecular weight (MW) of 196.34 kDa. The isotype control for AFM24 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P990730
CAS No.: 2755301-09-6
Synonyms: ARB202

Target:  

CD3 Cadherin

Research Areas:  

Cancer

Cabotamig is a humanized bispecific T-cell engager antibody targeting CDH17/CD3. Cabotamig is generated from anti-CDH17 monoclonal ARB102 by linking a CD3-binding scFv in the format of IgG4-scFv. Cabotamig can be used for the research of cancer, such as gastric cancer and colon cancers .
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Cat. No.: HY-P990903
CAS No.: 2577961-36-3
Synonyms: YMS-5A

Target:  

CD3

Research Areas:  

Inflammation/Immunology

HY-P990903 is an CD3E/CD33-targeting [H-γ1 _ L-κ-scFv heavy -κ]-dimer type bispecific antibody .
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Cat. No.: HY-P990714
CAS No.: 2750126-32-8

Target:  

CD3

Research Areas:  

Inflammation/Immunology

Obertamig is an engineered, humanized, anti-CD3E/HLA-G monoclonal antibody with humanized CH2-CH3 modifications and consists of half immunoglobulin IgG1 λ2 and a single-chain variable fragment (scFv) .
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Cat. No.: HY-P99772
CAS No.: 1957239-88-1
Synonyms: L19TNF

Target:  

TNF Receptor

Research Areas:  

Cancer

Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research .
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Cat. No.: HY-P991671
CAS No.: 3009026-69-8
Synonyms: JNJ-80948543

Research Areas:  

Cancer

Anafiltamig is a trivalent monoclonal antibody inhibitor targeting CD79B, CD3E and MS4A1. Anafiltamig consists of a humanized IgG1κ anti-CD79B arm and a bispecific scFv-based arm targeting CD3E and MS4A1. Anafiltamig simultaneously bridges T and B cells, activating T cells and specifically killing B cell tumors. Anafiltamig can be used for B cell malignancies such as non-Hodgkin lymphoma research .
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Cat. No.: HY-P991147
CAS No.: 2769743-01-1

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Ledostomig is an immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody targeting human netrin-5 (NTS5) and programmed death-1 (PD-1). Ledostomig is promising for research of various cancers .
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Cat. No.: HY-P99886
CAS No.: 219685-93-5
Synonyms: h5G1. 1-SC
Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction .
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Cat. No.: HY-P991151
CAS No.: 2923499-76-5
Synonyms: LBL-024

Target:  

PD-1/PD-L1 TNF Receptor

Research Areas:  

Cancer

Opamtistomig is a humanized immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody targeting human programmed death ligand 1 (PD-L1), CD274 and tumor necrosis factor receptor superfamily member 9 (TNFRSF9). Opamtistomig is promising for research of various solid tumors and hematological malignancies .
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Cat. No.: HY-P991461
Synonyms: XmAb968

Target:  

CD38

Research Areas:  

Cancer

AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .
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Cat. No.: HY-P991101

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Anti-Amyloid Beta Antibody (scFv59) is a human antibody expressed in CHO cells, targeting Amyloid-β. Anti-Amyloid Beta Antibody (scFv59) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P4043
CAS No.: 104504-34-9
Target:  

HBV

Research Areas:  

Infection Inflammation/Immunology

Hepatitis b virus pre-s region (120-145) is a preS2 peptide that inhibits the binding of single-chain Fv fragment (scFv) or IgG to r-HBsAg .
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Cat. No.: HY-P990695
CAS No.: 2642197-17-7

Target:  

EGFR

Research Areas:  

Inflammation/Immunology

Lunaxafusp is an anti-ERBB2 scFv-heavy-κ monoclonal antibody composed of a single chain variable fragment, an antibody heavy chain, and a kappa antibody light chain .
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Cat. No.: HY-P990912
CAS No.: 2852680-10-3
Synonyms: AK-129

Target:  

LAG-3

Research Areas:  

Inflammation/Immunology

HY-P990912 is an PDCD1/LAG3-targeting IgG1κ-[scFv-heavy -κ]2 type chimeric human and humanized antibody .
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Cat. No.: HY-P990935
CAS No.: 2779564-38-2
Synonyms: IMGN-151 Antibody

Target:  

Antifolate

Research Areas:  

Inflammation/Immunology

HY-P990935 is an FOLR1-targeting half-IG G1 -κ/(scFv -κ-heavy) -h-CH2-CH3 type chimeric antibody .
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