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selenoprotein

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By Targets:	Apoptosis (3) Autophagy (2) Caspase (1) COX (1) Ferroptosis (2) MDM-2/p53 (2) Reactive Oxygen Species (ROS) (1) SOD (1) TrxR (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Antibodies

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19980

Eprenetapopt 10+ Cited Publications APR-246; PRIMA-1Met	MDM-2/p53 Autophagy Apoptosis Ferroptosis	Cancer
Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

HY-N0864

Macranthoidin B Macranthoiside I	Apoptosis COX Reactive Oxygen Species (ROS) Caspase SOD	Cancer
Macranthoidin B (Macranthoiside I) is an orally active triterpene saponin. Macranthoidin B inhibits epithelial-mesenchymal transition in endometriosis via the COX‑2/PGE2 pathway, and also induces tumor cell apoptosis and inhibits their proliferation by regulating metabolism and increasing ROS levels . Macranthoidin B can be used in studies related to endometriosis, colorectal cancer and hepatocellular carcinoma .

HY-115640

TRFS-green 10+ Cited Publications	TrxR	Others
TRFS-green is a highly selective off−on fluorescent probe for imaging selenoprotein thioredoxin reductase (TrxR) in living cells. TRFS-green has the maximum absorbance at around 373 nm. After it is activated by TrxR, the maximum absorbance shifts to around 440 nm .

HY-P2759

Thioredoxin reductase TrxR	TrxR	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Thioredoxin reductase (TrxR) is a selenoprotein that plays a central role in cellular redox homeostasis by utilizing highly reactive selenocysteine (Sec) residues exposed to solvents at its active site. Thioredoxin reductase can be used for the study of diverse diseases, from rheumatoid arthritis and ischemia to cancer and parasitic infections .

HY-19980G

Eprenetapopt APR-246; PRIMA-1Met	MDM-2/p53 Apoptosis Autophagy Ferroptosis	Cancer
Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

Cat. No.	Product Name	Type

HY-19980G

Eprenetapopt APR-246; PRIMA-1Met	Fluorescent Dye
Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

Eprenetapopt

APR-246; PRIMA-1Met

Fluorescent Dye

Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

Cat. No.	Product Name	Type

HY-19980G

Eprenetapopt APR-246; PRIMA-1Met	Biochemical Assay Reagents
Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

Eprenetapopt

APR-246; PRIMA-1Met

Biochemical Assay Reagents

Macranthoidin B Macranthoiside I	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis COX Reactive Oxygen Species (ROS) Caspase SOD
Macranthoidin B (Macranthoiside I) is an orally active triterpene saponin. Macranthoidin B inhibits epithelial-mesenchymal transition in endometriosis via the COX‑2/PGE2 pathway, and also induces tumor cell apoptosis and inhibits their proliferation by regulating metabolism and increasing ROS levels . Macranthoidin B can be used in studies related to endometriosis, colorectal cancer and hepatocellular carcinoma .

Species:	Human (2)
Tag:	Tag Free (1) GST (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71603

	*SELM Protein, Human* SELENOM; SELM; selenoprotein M; SelM	Human	E. coli
	SELM protein emerged as a potential thiol-disulfide bond oxidoreductase that plays a key role in the complex disulfide bond formation process. This highlights the importance of SELM proteins in cellular machinery, actively contributing to the delicate coordination of molecular interactions. SELM Protein, Human is the recombinant human-derived SELM protein, expressed by E. coli , with tag free.

HY-P70905

	*EPT1 Protein, Human (GST)* Ethanolaminephosphotransferase 1; hEPT1; selenoprotein I; SelI; EPT1; KIAA1724; SELI	Human	E. coli
	The EPT1 protein is an ethanolamine phosphotransferase that crucially transfers phosphoethanolamine in the final step of PE synthesis. This process is critical for PE production and involves multiple membrane-related cellular functions. EPT1 Protein, Human (GST) is the recombinant human-derived EPT1 protein, expressed by E. coli , with N-GST labeled tag.

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Host:	Mouse (3) Rabbit (1)
Reactivity:	Human (3) mouse (1) rat (1) human (1)
Application:	IHC-P (2) ICC/IF (1) IF-Tissue (2) IP (1) WB (4) ELISA (1)
Isotype:	IgG (1) IgG1 (3)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810013

	Selenoprotein P Antibody (YA9357)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human, mouse, rat
	Selenoprotein P Antibody (YA9357) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Selenoprotein P.

HY-P80913

	Thioredoxin Reductase 2 Antibody (YA661) mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2.	WB	Human
	Thioredoxin Reductase 2 Antibody (YA661) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thioredoxin Reductase 2.

HY-P85559

	Thioredoxin Reductase 2 Antibody (YA5251) mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2.	WB, IHC-P, IF-Tissue	Human
	Thioredoxin Reductase 2 Antibody (YA5251) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Thioredoxin Reductase 2.

HY-P80913A

	Thioredoxin Reductase 2 Antibody (YA661)(PBS only) mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2.	WB	Human
	Thioredoxin Reductase 2 Antibody (YA661) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thioredoxin Reductase 2.

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19980G

Eprenetapopt APR-246; PRIMA-1Met	MDM-2/p53 Apoptosis Autophagy Ferroptosis	Cancer
Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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selenoprotein

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Antibodies

GMP Molecules

Natural
Products