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species-specific

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AIM2 (2) Calcium Channel (1) CGRP Receptor (1) Complement System (2) Environmental Pollutants (2) Ferroptosis (1) Insecticide (2) NOD-like Receptor (NLR) (2) P2X Receptor (3) Parasite (2) Pyroptosis (1) Renin (1) Sex Pheromone (3)
By Research Areas:	Cardiovascular Disease (2) Endocrinology (4) Infection (4) Inflammation/Immunology (2) Neurological Disease (6)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10301

MK-3207 5 Publications Verification	CGRP Receptor	Neurological Disease
MK-3207 is an orally active, highly selective and species-specific CGRP receptor antagonist (for human CGRP receptor: IC₅₀=0.12 nM; K_i=0.024 nM). MK-3207 can be used for migraine studies .

HY-144226

NLRP3/AIM2-IN-3 Maximum Cited Publications 10 Publications Verification	NOD-like Receptor (NLR) AIM2 Pyroptosis	Inflammation/Immunology
NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC₅₀ of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization .

HY-P1036

Compstatin 3 Publications Verification	Complement System	Others
Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC₅₀ values of 63 μM and 12 μM for classical and alterative complement pathway, respectively .

HY-144223

NLRP3/AIM2-IN-2 2 Publications Verification	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
NLRP3/aim2-in-2 (compound 8) is a new potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent cell death. Its < b > IC < sub > 50 < / sub > < / b > value is 0.2392 μ M。

HY-110237

BX430	P2X Receptor Calcium Channel	Cardiovascular Disease
BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC₅₀ of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.

HY-P1036A

Compstatin TFA 3 Publications Verification	Complement System	Others
Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibits only the activation of primates’ complement system. Compstatin TFA exhibits IC₅₀ values of 63 μM and 12 μM for classical and alterative complement pathway, respectively .

HY-15469

GW791343 dihydrochloride 1 Publications Verification	P2X Receptor	Neurological Disease
GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC₅₀ of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease .

HY-15470

GW791343 trihydrochloride	P2X Receptor	Neurological Disease
GW791343 trihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC₅₀ of 6.9-7.2. GW791343 trihydrochloride can enhance ATP rhythm. GW791343 trihydrochloride can be used in study of neurological disease .

HY-W014885

Decyl acetate	Sex Pheromone	Endocrinology
Decyl acetate is a synthetic pheromone attracting male false codling moths (Cryptophlebia leucotreta) .

HY-125625

ES 6864	Renin	Cardiovascular Disease
ES 6864 is an orally active, competitive inhibitor for human renin, with an IC₅₀ of 6.9 nM and a K_i of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets .

HY-121328

Empenthrin S-2852F	Parasite	Infection Neurological Disease
Empenthrin (S-2852F) is a synthetic pyrethroid. Empenthrin can be used in insecticides. Empenthrin shows a clear species-specificity in the inhibitory effect on the Pentobarbital (PTB)-metabolizing enzyme(s). Empenthrin prolongs PTB induced-sleeping time in mice through an inhibition of the PTB-metabolizing enzyme(s) in the liver, an effect that does not occur in rats. Empenthrin shows a clear species-specificity in the inhibitory effect on the PTB-metabolizing enzyme(s) .

HY-W710976

4-Methyl-5-nonanone	Sex Pheromone	Endocrinology
4-Methyl-5-nonanone is a species-specific sex pheromone isolated from the Asian palm red weevil (Rhynehophorus ferrugineus) .

HY-W331198

Tralopyril	Insecticide Ferroptosis	Infection
Tralopyril is an orally active, blood-brain barrier-penetrating antifouling insecticide and endocrine disruptor. By interfering with the thyroid hormone system and mitochondrial oxidative phosphorylation, Tralopyril downregulates the transcription of genes such as TRHR, Nkx2.1, TRα and induces ferroptosis. Tralopyril disrupts amino acid, energy and lipid metabolism, exhibits significant skeletal and reproductive toxicity, and causes developmental damage. Tralopyril has a long half-life in vivo and wide tissue distribution, posing potential risks to aquatic organisms and human health. Tralopyril shows species specificity in in vitro liver microsomal metabolism, exerts lethal effects on target insects and laboratory animals, and is commonly used in studies of chlorfenapyr poisoning and related toxic mechanisms .

HY-W150928

Tridecyl acetate	Others	Endocrinology
Tridecyl acetate is a species-specific female sex pheromone isolated from Adoxophyes sp. (smaller tea tortrix, STT) .

HY-W036015

(Z)-7-Tetradecen-2-one	Parasite	Infection
(Z)-7-Tetradecen-2-one acts as a species-specific nematicide. (Z)-7-Tetradecen-2-one induces terminal embryogenesis, morphological abnormalities, irreversible developmental arrest and increases eggshell permeability in Pristionchus pacificus embryos. (Z)-7-Tetradecen-2-one exerts olfactory attraction toward Pristionchus pacificus. (Z)-7-Tetradecen-2-one can be used to study the symbiotic relationship between hosts and nematodes .

HY-Y0282

Sodium bromide NSC 77384; Sanibrom 40	Environmental Pollutants	Neurological Disease
Sodium bromide (NSC 77384; Sanibrom 40) is a GABA-ergic system modulator that crosses the blood-brain barrier, and it effectively reduces and blocks epileptiform discharges. Sodium bromide exerts significant anticonvulsant effects by enhancing GABA-ergic inhibitory functions, such as increasing the amplitude of inhibitory postsynaptic currents and paired-pulse inhibition. Sodium bromide specifically enhances stimulation-induced extracellular alkalosis without affecting baseline pH or subsequent acidosis processes. Sodium bromide exhibits species-specific pharmacokinetic characteristics, competes with chloride ions for renal tubular reabsorption sites, and serves as a marker for extracellular fluid volume. Sodium bromide can be used in the research of epilepsy and related neurological diseases .

HY-W106720

(E)-11-Tetradecenyl acetate	Insecticide	Infection
(E)-11-Tetradecenyl acetate is a monounsaturated 14-carbon acetate insecticide and a component of the sex pheromone of the currant shoot borer. (E)-11-Tetradecenyl acetate triggers strong antennal responses in males and is used in combination with (Z)-11-tetradecenyl acetate to produce an attracting effect. (E)-11-Tetradecenyl acetate has important application value in the sustainable control of pests, and can be used to monitor population dynamics and implement mating disruption. (E)-11-Tetradecenyl acetate is highly species-specific, triggering only extremely weak responses and showing no attracting activity towards Melanotus communis beetles. (E)-11-Tetradecenyl acetate can be used in studies related to the currant shoot borer and targeted pest control .

HY-119716

Cyheptamide		Neurological Disease
Cyheptamide is an orally active anticonvulsant and antiepileptic agent. Cyheptamide exhibits moderate acute toxicity in animal models, with lethal doses varying by species specificity. Cyheptamide can be used in studies related to convulsions and epilepsy .

HY-W099803

(Z)-11-Hexadecenyl acetate	Environmental Pollutants Sex Pheromone	Endocrinology
(Z)-11-Hexadecenyl acetate is a component of insect sex pheromones, which elicits electroantennogram responses in male Plutella xylostella and induces their wing-fanning and claspers-exposing behaviors. (Z)-11-Hexadecenyl acetate also serves as a sex pheromone component of Spodoptera exigua and Chilo suppressalis. When used in combination with other pheromones, (Z)-11-Hexadecenyl acetate significantly enhances the attraction effect on male Tryporyza incertulas, and it exists in trace amounts in the eluate of the ovipositor of female Tryporyza incertulas. (Z)-11-Hexadecenyl acetate shows no attraction effect on male Cnaphalocrocis medinalis and exhibits species specificity .

Cat. No.	Product Name	Target	Research Area

HY-P1036

Compstatin 3 Publications Verification	Complement System	Others
Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC₅₀ values of 63 μM and 12 μM for classical and alterative complement pathway, respectively .

HY-P1036A

Compstatin TFA 3 Publications Verification	Complement System	Others
Compstatin TFA, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin TFA binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin TFA inhibits only the activation of primates’ complement system. Compstatin TFA exhibits IC₅₀ values of 63 μM and 12 μM for classical and alterative complement pathway, respectively .

Decyl acetate	Natural Products Animals Source Classification	Sex Pheromone
Decyl acetate is a synthetic pheromone attracting male false codling moths (Cryptophlebia leucotreta) .

4-Methyl-5-nonanone	Natural Products Animals Source Classification	Sex Pheromone
4-Methyl-5-nonanone is a species-specific sex pheromone isolated from the Asian palm red weevil (Rhynehophorus ferrugineus) .

Tridecyl acetate	Natural Products Animals Source Classification	Others
Tridecyl acetate is a species-specific female sex pheromone isolated from Adoxophyes sp. (smaller tea tortrix, STT) .

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species-specific

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