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Cat. No.: HY-127147

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Fazadinium bromide

(Synonyms: AH 8165 bromide)

Fazadinium bromide (AH 8165 bromide) is a species-specific neuromuscular blocking agent that primarily targets the acetylcholine receptor (AChR) at the skeletal neuromuscular junction, blocking the receptor agonist binding site in a competitive and reversible manner. Fazadinium bromide induces sustained tetanic fade, and tetanic contractions are more sensitive than single twitches. Fazadinium bromide can be used in anesthesia and research related to neuromuscular transmission.

For research use only. We do not sell to patients.

CAS No.: 49564-56-9
Formula: C₂₈H₂₄Br₂N₆
Molecular Weight:604.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Fazadinium bromide Chemical Structure

CAS No.: 49564-56-9

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

All mAChR Isoforms :

In Vivo

Fazadinium bromide (0.125-4.0 mg/kg; i.v.) produces complete neuromuscular blockade in anaesthetized cats at 2.0 mg/kg i.v. with a 1-minute onset and 15-minute mean recovery time, while inducing vagal blockade at lower doses and minimal sympathetic blockade at supramaximal doses^[1].
Fazadinium bromide (0.0625-4.0 mg/kg; i.v.) is four times more potent in anaesthetized rhesus monkeys than in cats, producing complete neuromuscular blockade at 0.5 mg/kg i.v. with a 1.5-5 minute onset and 36-minute mean recovery time, while inducing vagal blockade at near-paralyzing doses and sympathetic blockade at supramaximal doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 49564-56-9
Molecular Weight 604.34
Formula C₂₈H₂₄Br₂N₆
SMILES

CC1=C(N(C2=CC=CC=[N+]21)/N=N/N3C(C4=CC=CC=C4)=C([N+]5=CC=CC=C53)C)C6=CC=CC=C6.[Br-].[Br-]
Synonyms

AH 8165 bromide
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hughes R, Payne JP, Sugai N. Studies on fazadinium bromide (ah 8165): a new non-depolarizing neuromuscular blocking agent. Canadian Anaesthetists' Society journal. 1976 Jan;23(1):36-47. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Fazadinium bromide

All mAChR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Fazadinium bromide Related Classifications

HY-127147 Related Classifications