1787787-60-3
Chemical Structure
NLRP3/AIM2-IN-3
- CAS No.: 1787787-60-3
- Formula:C16H14N2O2
- Molecular Weight:266.29
IUPAC Name: N-(3-hydroxyphenyl)-2-(1H-indol-6-yl)acetamide
InChIKey: UOBOMCZZCHPHBU-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(O)=C1)CC2=CC3=C(C=C2)C=CN3
Biological Activity: NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization[1].
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NLRP3/AIM2-IN-3 | 98.23% | NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization. | ||||||||||||||||||||
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Keywords
