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Results for "

syk

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Syk (87) 5-HT Receptor (6) Adrenergic Receptor (3) Akt (1) AP-1 (1) Apoptosis (22) Aurora Kinase (1) Autophagy (2) Bacterial (1) Btk (4) c-Kit (4) Calcium Channel (1) Caspase (1) CDK (2) Chemerin Receptor (1) Complement System (1) COX (1) Dipeptidyl Peptidase (1) Drug Isomer (2) EGFR (1) Endogenous Metabolite (2) ERK (4) FAK (2) FLT3 (14) FXR (2) GSK-3 (1) Histamine Receptor (1) Influenza Virus (1) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (3) JAK (9) LRRK2 (1) MEK (1) Mixed Lineage Kinase (2) MMP (2) NF-κB (3) NO Synthase (4) NOD-like Receptor (NLR) (1) Opioid Receptor (2) P-selectin (1) p38 MAPK (4) PAK (2) PANoptosis (1) PARP (2) Phosphatase (1) PI3K (2) PKA (1) PKC (4) Prostaglandin Receptor (1) PROTACs (1) Pyk2 (2) Reactive Oxygen Species (ROS) (2) Reference Standards (11) RET (1) RIG-I-like receptor (RLR) (1) Small Interfering RNA (siRNA) (3) Src (9) STAT (1) TGF-beta/Smad (1) TNF Receptor (1) TREM receptor (4) VEGFR (4)
By Research Areas:	Cancer (56) Cardiovascular Disease (10) Endocrinology (4) Infection (2) Inflammation/Immunology (68) Metabolic Disease (4) Neurological Disease (11)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

113

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Syk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13038A

Fostamatinib 10+ Cited Publications R788	Syk FLT3	Inflammation/Immunology Cancer
Fostamatinib (R788) is the oral proagent of the active compound R406 . R406 is an orally available and competitive *Syk/FLT3* inhibitor with a K_i of 30 nM and an IC₅₀ of 41 nM . R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

HY-10230

Midostaurin Maximum Cited Publications 37 Publications Verification PKC412; CGP 41251	PKC VEGFR c-Kit NO Synthase Apoptosis	Cancer
Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, *Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ* and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-12067

R406 35+ Cited Publications	Syk FLT3 Apoptosis	Inflammation/Immunology Cancer
R406 is an orally available and competitive *Syk/FLT3* inhibitor for ATP binding with a K_i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC₅₀ of 41 nM, measured at an ATP concentration corresponding to its K_m value. R406 reduces immune complex-mediated inflammation . R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

HY-13518

Piceatannol Maximum Cited Publications 24 Publications Verification Astringenin; trans-Piceatannol	Syk Autophagy Apoptosis Endogenous Metabolite	Cancer
Piceatannol is a well-known *Syk* inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells .

HY-15968

Entospletinib 10+ Cited Publications GS-9973	Syk	Cancer
Entospletinib (GS-9973) is an orally bioavailable, selective *Syk* inhibitor with an IC₅₀ of 7.7 nM.

HY-103018

Gusacitinib 1 Publications Verification ASN-002	JAK Syk	Inflammation/Immunology Cancer
Gusacitinib (ASN-002) is an orally active dual *SYK/JAK* kinase inhibitor with IC₅₀ values of 5, 46, 4, 11 and 8 nM for *SYK, JAK1, JAK2, JAK3* and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma .

HY-145598

Sovleplenib HMPL-523	Syk	Cancer
Sovleplenib (HMPL-523) is a highly potent, orally available and selective *SYK* inhibitor with an IC₅₀ of 25 nM. Anti-tumor activity. Sovleplenib can be used for the research of immune thrombocytopenia (ITP) .

HY-13038

Fostamatinib Disodium 10+ Cited Publications R788Disodium	Syk FLT3	Inflammation/Immunology Cancer
Fostamatinib Disodium (R788 Disodium) is the oral proagent of the active compound R406 . R406 is an orally available and competitive *Syk/FLT3* inhibitor with a K_i of 30 nM and an IC₅₀ of 41 nM . R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

HY-15323

PRT062607 Hydrochloride 4 Publications Verification P505-15 Hydrochloride	Syk Mixed Lineage Kinase PAK Pyk2 FAK Apoptosis Src	Cancer
PRT062607 (P505-15) Hydrochloride is an orally available *Syk* inhibitor (IC₅₀: 1 nM) that inhibits inflammation and induction Apoptosis. PRT062607 Hydrochloride exerts potent antitumor activity in tumor xenograft mouse models .

HY-15999

Cerdulatinib 5+ Cited Publications PRT062070; PRT2070	JAK Syk	Cancer
Cerdulatinib (PRT062070) is a selective Tyk2 inhibitor with an IC₅₀ of 0.5 nM. Cerdulatinib (PRT062070) also is a dual JAK and *SYK* inhibitor with IC₅₀s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively.

HY-109091

Lanraplenib 2 Publications Verification GS-9876	Syk	Inflammation/Immunology Cancer
Lanraplenib (GS-9876) is a highly selective and orally active *SYK* inhibitor (IC₅₀=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib (GS-9876) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans .

HY-11108

R406 free base 35+ Cited Publications	Syk FLT3 Apoptosis	Inflammation/Immunology Cancer
R406 free base is an orally available and competitive *Syk/FLT3* inhibitor for ATP binding with a K_i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC₅₀ of 41 nM, measured at an ATP concentration corresponding to its K_m value. R406 free base reduces immune complex-mediated inflammation . R406 free base also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

HY-14985

BAY 61-3606 dihydrochloride 5+ Cited Publications	Syk Apoptosis	Inflammation/Immunology Cancer
BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective *Syk* inhibitor with a K_i of 7.5 nM an IC₅₀ of 10 nM . BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell . BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates . Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells .

HY-100867A

Mivavotinib monohydrochloride TAK-659 monohydrochloride; CB-659 monohydrochloride	Syk FLT3	Cancer
TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC₅₀ of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL) .

HY-P991734

VHB937	TREM receptor Syk Calcium Channel	Neurological Disease Inflammation/Immunology
VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as *Syk* phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research .

HY-N7675

Flavanomarein	NF-κB TGF-beta/Smad Syk	Cardiovascular Disease Neurological Disease Metabolic Disease
Flavanomarein is a substance with cytoprotective, anti-inflammatory and antioxidant activities, with a K_a of 3.064e-5 M against human *Syk*. Flavanomarein enhances the phosphorylation level of AKT, regulates the expression of PKC-δ, P85α, PKC-β1, Sirt1, Bcl-2 and ICAD, and inhibits the nuclear translocation of NF-κB p65. Flavanomarein regulates EMT marker proteins, promotes the proliferation of HK-2 cells, and protects neuronal cells from 6-OHDA-induced neurotoxic damage. Flavanomarein can be used in studies related to Parkinson's disease and diabetic nephropathy.

HY-13038B

Fostamatinib disodium hexahydrate 10+ Cited Publications R788 disodium hexahydrate	Syk FLT3	Inflammation/Immunology Cancer
Fostamatinib (R788) disodium hexahydrate is the oral proagent of the active compound R406 . R406 is an orally available and competitive *Syk/FLT3* inhibitor with a K_i of 30 nM and an IC₅₀ of 41 nM . R406 also inhibits Lyn (IC₅₀=63 nM) and Lck (IC₅₀=37 nM) .

HY-12072

Lck Inhibitor 3 Publications Verification	Src	Inflammation/Immunology
Lck Inhibitor is a potent, orally active Lck (lymphocyte specific kinase) inhibitor with IC₅₀s of 7, 2.1, 4.2 and 200 nM for Lck, Lyn, Src and Syk kinases, respectively. Lck Inhibitor shows >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Lck Inhibitor inhibits T cell proliferation and in vivo models of arthritis .

HY-12974

PRT-060318 4 Publications Verification PRT318	Syk Apoptosis	Inflammation/Immunology Cancer
PRT-060318 (PRT318) s a potent, selective and orally active tyrosine kinase *Syk* inhibitor with an IC₅₀ of 3 nM. PRT-060318 suppresses chronic lymphocytic leukemia (CLL) B cell activation and migration, and induces apoptosis. PRT-060318 prevents Heparin (HY-17567)-induced thrombocytopenia and thrombosis in a transgenic mouse model. PRT-060318 dihydrochloride can be used for CLL and thrombus research .

HY-15999A

Cerdulatinib hydrochloride 5+ Cited Publications PRT062070 hydrochloride; PRT2070 hydrochloride	Syk JAK	Cancer
Cerdulatinib hydrochloride (PRT062070) is a selective, oral active and reversible ATP-competitive inhibitor of dual *SYK* and JAK, with IC₅₀s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for *SYK* and Tyk2, JAK1, 2, 3, respectively. Cerdulatinib hydrochloride could be used to research autoimmune disease and B-cell malignancies .

HY-178129

MRL-SYKi	Syk	Inflammation/Immunology
MRL-SYKi is a chemical probe for gain-of-function variants of spleen tyrosine kinase (SYK). MRL-SYKi reduces the catalytic activity of *SYK* ^S550Y, *SYK* ^S550F and *SYK* ^P342T, and downregulates the phosphorylation level of *SYK* ^S550Y. MRL-SYKi serves as a template for developing NanoBRET tracers targeting *SYK, enabling NanoBRET cellular target engagement assays for gain-of-function variants of SYK*. MRL-SYKi is applicable to research related to inflammatory and immune diseases .

HY-174369

TREM2 agonist-3	TREM receptor Syk	Neurological Disease
TREM2 agonist-3 (Compound 4i) is a TREM2 agonist with a K_D value of 19.0 µM. The K_D value of TREM2 agonist-3 for TREM1 is 39.8 µM. TREM2 agonist-3 induces an increase in phosphorylated *SYK* levels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases and other diseases associated with TREM2 dysfunction .

HY-P6442

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of *Syk, ERK* and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury .

HY-16420

R112	Syk	Inflammation/Immunology
R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk) kinase. R112 inhibits Syk kinase activity with an IC₅₀ value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis .

HY-16902

RO9021	Syk	Inflammation/Immunology
RO9021 is an orally bioavailable, novel ATP-competitive inhibitor of *SYK, with an average IC₅₀* of 5.6 nM.

HY-109091B

Lanraplenib succinate 2 Publications Verification GS-9876 succinate	Syk	Inflammation/Immunology Cancer
Lanraplenib succinate (GS-9876 succinate) is a highly selective and orally active *SYK* inhibitor (IC₅₀=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib succinate (GS-9876 succinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans .

HY-109082

Cevidoplenib SKI-O-703	Syk	Inflammation/Immunology
Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC₅₀s of 6.2 nM (Syk), 1.859 μM (Jak2), 5.807 μM (Jak3), 0.412 μM (RET), 0.687 μM (KOR), 1.783 μM (FLT3), 16.96 μM (FGFR1), 5.662 μM (FGFR3), and 0.709 μM (Pyk2), respectively .

HY-178324

T2M-010	TREM receptor Syk	Neurological Disease Inflammation/Immunology
T2M-010 is a potent, brain-penetrant TREM2 agonist (K_d = 0.83 μM). T2M-010 activates receptor-proximal signaling, inducing *SYK* phosphorylation in TREM2-expressing cells, and promotes microglial phagocytosis. T2M-010 can be used for the study of protective microglial responses relevant to Alzheimer’s disease (AD) .

HY-100338

CNX-500	Btk	Cancer
CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC₅₀ of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn .

HY-112390A

Syk Inhibitor II 2 Publications Verification	Syk 5-HT Receptor	Inflammation/Immunology
Syk Inhibitor II is a potent, high selective and ATP-competitive *Syk* inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect .

HY-136198

SRX3207	Syk PI3K	Cancer
SRX3207 is an orally active and first-in-class dual *Syk/PI3K* inhibitor, with IC₅₀ values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression .

HY-76474A

BAY 61-3606 hydrochloride 4 Publications Verification	Apoptosis Syk	Inflammation/Immunology Cancer
BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

HY-76474

BAY 61-3606	Syk Apoptosis	Inflammation/Immunology Cancer
BAY 61-3606 is an orally available, ATP-competitive, reversible and highly selective *Syk* inhibitor with a K_i of 7.5 nM and an IC₅₀ of 10 nM . BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell . BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates . Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells .

HY-123846

MLS-0437605 1 Publications Verification	Phosphatase	Cardiovascular Disease
MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC₅₀ of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs) .

HY-12736A

GSK143 dihydrochloride 1 Publications Verification	Syk ERK	Inflammation/Immunology Cancer
GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.5. GSK143 dihydrochloride inhibits phosphorylated Erk (pErk: pIC₅₀=7.1) . GSK143 dihydrochloride reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice .

HY-103094

LY266097 hydrochloride	5-HT Receptor	Inflammation/Immunology
LY266097 hydrochloride is a selective 5-HT2B receptor antagonist with pK_is of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression .

HY-131341

Syk-IN-4	Syk	Inflammation/Immunology Cancer
Syk-IN-4 is a potent, selective and orally bioavailable *SYK* inhibitor with an IC₅₀ of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers .

HY-112386

OXSI-2	Syk	Inflammation/Immunology
OXSI-2 is a bioavailable, cell-permeable *Syk* inhibitor with an EC₅₀ of 313 nM and an IC₅₀ of 14 nM .

HY-112319

(R,S)-MK-8457	Drug Isomer Syk	Cardiovascular Disease Inflammation/Immunology
(R,S)-MK-8457 is a stereoisomer of MK-8457. MK-8457 is a dual inhibitor of *Syk* and ZAP70 .

HY-N10182

Spinacetin 1 Publications Verification	Histamine Receptor	Inflammation/Immunology
Spinacetin is a natural product that can be isolated from Inula japonica. Spinacetin inhibits the release of histamine. Spinacetin has anti-inflammatory activity .

HY-12657

Syk-IN-1 1 Publications Verification	Syk	Inflammation/Immunology
Syk-IN-1 (compound 4) is a potent *Syk* inhibitor, with an IC₅₀ of 35 nM .

HY-15324

PRT062607 acetate 4 Publications Verification P505-15 acetate; PRT-2607 acetate; BIIB-057 acetate	Syk Src Mixed Lineage Kinase PAK Pyk2 FAK Apoptosis	Cancer
PRT062607 (P505-15) acetate is an orally available *Syk* inhibitor (IC₅₀: 1 nM) that inhibits inflammation and induction Apoptosis. PRT062607 acetate exerts potent antitumor activity in tumor xenograft mouse models . .

HY-109082A

Cevidoplenib dimesylate SKI-O-703 dimesylate	Syk	Inflammation/Immunology
Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities .

HY-100867

Mivavotinib TAK-659; CB-659	Syk FLT3	Cancer
TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC₅₀ of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL) .

HY-112809

GSK2646264	Syk Src LRRK2 GSK-3 JAK VEGFR Aurora Kinase	Inflammation/Immunology
GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.1. GSK2646264 also inhibits other kinases with pIC₅₀ values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin .

HY-145029

SYK/JAK-IN-1	Syk JAK	Inflammation/Immunology Cancer
SYK/JAK-IN-1 is dual *SYK/JAK* inhibitor with IC₅₀s of <5 nM for SYK and JAK2, respectively .

HY-120533

Syk-IN-11	Syk	Inflammation/Immunology
Syk-IN-11 (BIIB-057) is a selective *Syk* inhibitor with an IC₅₀ Of 13 nM. Syk-IN-11 can be used in the study of arthritis and chronic lymphocytic leukemia .

HY-124146

BI1002494	Syk	Inflammation/Immunology
BI1002494 is an orally active, potent, and selective spleen tyrosine kinase (SYK) inhibitor. BI 1002494 exhibits an IC₅₀ of 115 nM in inhibiting high-affinity IgE receptor-mediated mast cell and basophil degranulation. BI1002494 can be utilized in immunology reesearch .

HY-12736

GSK143	Syk ERK	Inflammation/Immunology Cancer
GSK143 is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.5. GSK143 inhibits phosphorylated Erk (pErk: pIC₅₀=7.1) . GSK143 reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice .

HY-10230S

Midostaurin-d5 PKC412-d₅; CGP 41251-d₅	Isotope-Labeled Compounds PKC Syk Akt PKA c-Kit	Cancer
Midostaurin-d₅ (PKC412-d₅) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM .

Cat. No.	Product Name	Target	Research Area

HY-P6442

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of *Syk, ERK* and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury .

HY-P2505

Syk Kinase Peptide Substrate	Syk	Others
Syk Kinase Peptide Substrate is a Syk kinase peptide substrate.

HY-P2504

Syk Kinase Peptide Substrate, Biotin labeled	Syk	Others
Syk Kinase Peptide Substrate, Biotin labeled is a biotin-labled Syk kinase peptide substrate.

Cat. No.	Product Name	Target	Research Area	Image

HY-P991734

VHB937	TREM receptor Syk Calcium Channel	Neurological Disease Inflammation/Immunology
VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as *Syk* phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research .

HY-P990119

Anti-Mouse Kappa Immunoglobulin Light Chain Antibody (HB-58)	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse Kappa Immunoglobulin Light Chain Antibody (HB-58) is an anti-mouse Kappa Immunoglobulin Light Chain IgG1 monoclonal antibody. Anti-Mouse Kappa Immunoglobulin Light Chain Antibody (HB-58) can reduce the phosphorylation levels of Src and Syk in B cells and the antigen presentation ability of B cells. Anti-Mouse Kappa Immunoglobulin Light Chain Antibody (HB-58) can be used for research on immunology .

HY-P991954

GT103	Complement System Syk	Inflammation/Immunology Cancer
GT103 is a human-derived monoclonal antibody targeting complement factor H (CFH). GT103 binds to a conformationally distinct epitope of CFH on tumor cells. GT103 activates the classical complement pathway, induces complement-dependent cytotoxicity, and triggers antibody-dependent cellular phagocytosis (ADCP) of tumor cells. GT103 increases calreticulin translocation to tumor cell plasma membranes. GT103 mediates B-cell activation via *Syk* kinase phosphorylation. GT103 inhibits tumor growth and metastasis in animal models. GT103 can be used for the research of non-small cell lung cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13518

Piceatannol Maximum Cited Publications 24 Publications Verification Astringenin; trans-Piceatannol	Microorganisms Stilbenes Rheum palmatum L. Classification of Application Fields Polygonaceae Plants Disease Research Fields Source Classification Cancer	Syk Autophagy Apoptosis Endogenous Metabolite
Piceatannol is a well-known *Syk* inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells .

HY-N7675

Flavanomarein	Cardiovascular Disease Structural Classification Classification of Application Fields Cercis chinensis Bunge Metabolic Disease Plants Compositae Flavonoids other families Flavonones Phenols Polyphenols Disease Research Fields Source Classification	NF-κB TGF-beta/Smad Syk
Flavanomarein is a substance with cytoprotective, anti-inflammatory and antioxidant activities, with a K_a of 3.064e-5 M against human *Syk*. Flavanomarein enhances the phosphorylation level of AKT, regulates the expression of PKC-δ, P85α, PKC-β1, Sirt1, Bcl-2 and ICAD, and inhibits the nuclear translocation of NF-κB p65. Flavanomarein regulates EMT marker proteins, promotes the proliferation of HK-2 cells, and protects neuronal cells from 6-OHDA-induced neurotoxic damage. Flavanomarein can be used in studies related to Parkinson's disease and diabetic nephropathy.

HY-N0805

Alisol B 23-acetate 3 Publications Verification 23-Acetylalismol B; 23-O-Acetylalisol B; Alisol B monoacetate	Triterpenes Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Other Diseases Alismataceae Plants Disease Research Fields Source Classification	Apoptosis Reactive Oxygen Species (ROS) CDK MMP PARP FXR Syk
Alisol B 23-acetate is an orally active prototerpane-type triterpenoid. Alisol B 23-acetate can be isolated from Alisma orientalis. Alisol B 23-acetate induces Apoptosis, promotes ROS generation, downregulates CDK4/6, MMP-2/9, upregulates cleaved PARP, activates FXR and inhibits *Syk*. Alisol B 23-acetate has anti-inflammatory and hepatoprotective activities. Alisol B 23-acetate protects the kidney from ischemia-reperfusion injury. Alisol B 23-acetate has anticancer activity against ovarian cancer, colon cancer, lung cancer, and gastric cancer. Alisol B 23-acetate can be used in the study of atherosclerosis and allergic asthma .

HY-W031757

Anthraquinone-2-carboxylic acid	Quinones Structural Classification other families Classification of Application Fields Anthraquinones Acrostichum speciosum Willd. Plants Inflammation/Immunology Disease Research Fields	Influenza Virus Bacterial Dipeptidyl Peptidase COX NF-κB AP-1 RIG-I-like receptor (RLR) STAT
Anthraquinone-2-carboxylic acid is an orally active anthraquinone compound and Antibacterial agent. Anthraquinone-2-carboxylic acid can be isolated from Bajitian. Anthraquinone-2-carboxylic acid inhibits the activation of DPP-IV, COX-2, NF-κB and AP-1. Anthraquinone-2-carboxylic acid blocks IAV-induced activation of the RIG-I/STAT1 pathway, alleviates IAV-mediated weight loss, and protects against lethal IAV infection. Anthraquinone-2-carboxylic acid inhibits the growth of various Staphylococcus strains. It possesses potent anti-inflammatory, immunomodulatory, analgesic and antibacterial activities .\n

HY-N10182

Spinacetin 1 Publications Verification	Phyllodium pulchellum (L.) Desv. Flavonols Flavonoids Plants Compositae Source Classification	Histamine Receptor
Spinacetin is a natural product that can be isolated from Inula japonica. Spinacetin inhibits the release of histamine. Spinacetin has anti-inflammatory activity .

HY-13518R

Piceatannol (Standard) Astringenin (Standard); trans-Piceatannol (Standard)	Structural Classification Microorganisms Stilbenes Rheum palmatum L. Polygonaceae Plants Source Classification	Reference Standards Syk Autophagy Apoptosis Endogenous Metabolite
Piceatannol (Standard) is the analytical standard of Piceatannol. This product is intended for research and analytical applications. Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells .

HY-N3702

Dehydroabietinol	Structural Classification Terpenoids Verbenaceae Callicarpa bodinieri Levl. Diterpenoids Plants Source Classification	Syk
Dehydroabietinol is a *SYK* inhibitor with an IC₅₀ of 46.4 μM. Dehydroabietinol inhibits the growth of Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes and Leishmania infantum promastigotes. Dehydroabietinol indirectly inhibits the growth of Plasmodium falciparum, alters the erythrocyte membrane, and induces spherostomatocyte transformation and endovesicle formation. Dehydroabietinol can be used in studies related to immune-mediated diseases, Chagas disease, leishmaniasis and malaria .

HY-N7314

Asebogenin	Glycosmis parviflora Kurz. Phenols Polyphenols Plants Salicaceae Source Classification	Syk
Asebogenin has antimalarial activity in vitro . Asebogenin can inhibit the phosphorylation of *Syk*, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps .

HY-N7675A

(2R)-Flavanomarein	Flavonoids Cercis chinensis Bunge Flavonones Plants Compositae Source Classification	Others
(2R)-Flavanomarein is a predominant flavonoid of Coreopsis tinctoria Nutt with protective effects against diabetic nephropathy. (2R)-Flavanomarein has good antioxidative, antidiabetic, antihypertensive and anti-hyperlipidemic activities .

HY-N0805R

Alisol B 23-acetate (Standard) 23-Acetylalismol B (Standard); 23-O-Acetylalisol B (Standard); Alisol B monoacetate (Standard)	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Terpenoids Alismataceae Plants Source Classification	Reference Standards Apoptosis Reactive Oxygen Species (ROS) CDK MMP PARP FXR Syk
Alisol B 23-acetate (Standard) is the analytical standard of Alisol B 23-acetate (HY-N0805). This product is intended for research and analytical applications. Alisol B 23-acetate is an orally active prototerpane-type triterpenoid. Alisol B 23-acetate can be isolated from Alisma orientalis. Alisol B 23-acetate induces Apoptosis, promotes ROS generation, downregulates CDK4/6, MMP-2/9, upregulates cleaved PARP, activates FXR and inhibits *Syk*. Alisol B 23-acetate has anti-inflammatory and hepatoprotective activities. Alisol B 23-acetate protects the kidney from ischemia-reperfusion injury. Alisol B 23-acetate has anticancer activity against ovarian cancer, colon cancer, lung cancer, and gastric cancer. Alisol B 23-acetate can be used in the study of atherosclerosis and allergic asthma .

Recombinant Proteins Recommended:

Species:	Human (4)
Tag:	His (2) Tag Free (1) Avi (1) GST (1)
Source:	Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701637

	SYK Protein, Human (sf9, His) syk; Tyrosine-protein kinase syk; Spleen tyrosine kinase; p72-syk	Human	Sf9 insect cells
	SYK protein is a non-receptor tyrosine kinase that mediates signal transduction across different receptors, including B-cell receptors (BCR), affecting innate and adaptive immunity, cell adhesion, and osteoclast maturation , platelet activation and vascular development. SYK forms complexes with activated receptors, phosphorylates downstream effectors, and is critical in BCR and T cell receptor signaling. SYK Protein, Human (sf9, His) is the recombinant human-derived SYK protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P701638

	SYK Protein, Human (Active, sf9) syk; Tyrosine-protein kinase syk; Spleen tyrosine kinase; p72-syk	Human	Sf9 insect cells
	SYK protein is a non-receptor tyrosine kinase that mediates signal transduction across different receptors, including B-cell receptors (BCR), affecting innate and adaptive immunity, cell adhesion, and osteoclast maturation , platelet activation and vascular development. SYK forms complexes with activated receptors, phosphorylates downstream effectors, and is critical in BCR and T cell receptor signaling. SYK Protein, Human (sf9) is the recombinant human-derived SYK protein, expressed by sf9 insect cells , with tag free.

HY-P702728

	SYK Protein, Human (Active, Biotinylated, sf9, Avi) syk; spleen tyrosine kinase; tyrosine-protein kinase syk; p72-syk; FLJ25043; FLJ37489; DKFZp313N1010	Human	Sf9 insect cells
	SYK protein is a non-receptor tyrosine kinase that mediates signal transduction across different receptors, including B-cell receptors (BCR), affecting innate and adaptive immunity, cell adhesion, and osteoclast maturation, platelet activation and vascular development. SYK forms complexes with activated receptors, phosphorylates downstream effectors, and is critical in BCR and T cell receptor signaling. SYK Protein, Human (Biotinylated, sf9, Avi) is the recombinant human-derived SYK, expressed by Sf9 insect cells, with N-Avi labeled tag.

HY-P702729

	ZAP70 Protein, Human (Active, sf9, His, GST) ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; SRK, zeta chain (TCR) associated protein kinase (70 kD); tyrosine-protein kinase ZAP-70; STD; ZAP 70; syk-related tyrosine kinase; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; zeta-chain associated protein kinase, 70kD; SRK; TZK; ZAP-70; FLJ17670; FLJ17679	Human	Sf9 insect cells
	ZAP70 Protein, Human (sf9, His, GST) is the recombinant human-derived ZAP70, expressed by Sf9 insect cells , with His, GST labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-10230S

Midostaurin-d5
Midostaurin-d₅ (PKC412-d₅) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM .

HY-103018S

Gusacitinib-d4

Gusacitinib-d₄ (ASN-002-d₄) is the deuterium labeled Gusacitinib (HY-103018). Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC₅₀ values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma .

HY-W751179

Midostaurin-13C6

Midostaurin- ¹³C₆ (PKC412- ¹³C₆) is the ¹³C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

Host:	Mouse (10) Rabbit (5)
Reactivity:	Human (15) Rat (3) Mouse (5)
Application:	IHC-P (3) ICC/IF (8) IP (6) WB (13) FC (5) ELISA (11)
Isotype:	IgG (1) IgG1 (7) IgG/Kappa (3) IgG2b (2) IgG,IgG/Kappa (1)
Conjugation:	Non-conjugated (15) Biotin (1)
Clonality:	Monoclonal (9) Monoclonal Antibody (1)
Modification:	Phosphorylated (2) Unmodified (8)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86408

	SYK Antibody (YA6100) syk; Tyrosine-protein kinase syk; Spleen tyrosine kinase; p72-syk	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	SYK Antibody (YA6100) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SYK.

HY-P86108

	*Phospho-SYK(Tyr525/526)Antibody(YA5800)* syk; Tyrosine-protein kinase syk; Spleen tyrosine kinase; p72-syk	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-SYK(Tyr525/526)Antibody(YA5800) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-SYK(Tyr525/526).

HY-P86168

	*Phospho-Zap70(Tyr319)/Syk(Tyr352)Antibody (YA5860)* ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; syk-related tyrosine kinase; syk; Tyrosine-protein kinase syk; Spleen tyrosine kinase; p72-syk;	WB, ICC/IF, ELISA	Human, Mouse
	Phospho-Zap70(Tyr319)/Syk(Tyr352)Antibody (YA5860) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Zap70(Tyr319)/Syk(Tyr352).

HY-P84329

	SYK Antibody (YA4026) p72-syk	WB, FC, ELISA	Human
	SYK Antibody (YA4026) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYK.

HY-P84328

	SYK Antibody (YA4025) p72-syk	ICC/IF, FC, ELISA	Human
	SYK Antibody (YA4025) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYK.

HY-P84328A

	SYK Antibody (YA4025)(PBS only) p72-syk	ICC/IF, FC, ELISA	Human
	SYK Antibody (YA4025) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYK.

HY-P84329A

	SYK Antibody (YA4026)(PBS only) p72-syk	WB, FC, ELISA	Human
	SYK Antibody (YA4026) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYK.

HY-P810592

	*Phospho-Syk* (Tyr352) Antibody (YA9856)** p72-syk	WB, ICC/IF, FC	Human
	Phospho-Syk (Tyr352) Antibody (YA9856) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-Syk (Tyr352).

HY-P80937

	ZAP70 Antibody (YA651) ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; syk-related tyrosine kinase	WB, IP	Human
	ZAP70 Antibody (YA651) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ZAP70.

HY-P86150

	ZAP70 Antibody (YA5842) ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; syk-related tyrosine kinase	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ZAP70 Antibody (YA5842) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ZAP70.

HY-P80937A

	ZAP70 Antibody (YA651)(PBS only) ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; syk-related tyrosine kinase	WB, IP	Human
	ZAP70 Antibody (YA651) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ZAP70.

HY-P85379

	SYK Antibody (YA5071) SLC22A1; OCT1; Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1	WB, ELISA	Human
	SYK Antibody (YA5071) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SYK.

HY-P85379A

	SYK Antibody (YA5071)(PBS only) SLC22A1; OCT1; Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1	WB, ELISA	Human
	SYK Antibody (YA5071) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SYK.

HY-P85592

	ZAP70 Antibody (YA5284) 70 kDa zeta associated protein; 70 kDa zeta-associated protein; FLJ17670; FLJ17679; Selective T cell defect; SRK; STD; syk related tyrosine kinase; syk-related tyrosine kinase; Truncated ZAP kinase; Tyrosine protein kinase ZAP70; Tyrosine-protein kinase ZAP-70; TZK; ZAP 70; ZAP-70; ZAP70; ZAP70_HUMAN; Zeta chain associated protein kinase 70kD; Zeta chain associated protein kinase 70kDa; Zeta chain associated protein kinase 70kDa isoform 1; Zeta chain associated protein kinase 70kDa isoform 2; Zeta chain TCR associated protein kinase 70kD; Zeta chain TCR associated protein kinase 70kDa.	WB, IP	Human
	ZAP70 Antibody (YA5284) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ZAP70.

HY-P85831

	ZAP70 Antibody (YA5523) 70 kDa zeta associated protein; 70 kDa zeta-associated protein; FLJ17670; FLJ17679; Selective T cell defect; SRK; STD; syk related tyrosine kinase; syk-related tyrosine kinase; Truncated ZAP kinase; Tyrosine protein kinase ZAP70; Tyrosine-protein kinase ZAP-70; TZK; ZAP 70; ZAP70; ZAP70_HUMAN; Zeta chain associated protein kinase 70kD; Zeta chain associated protein kinase 70 kDa; Zeta chain associated protein kinase 70 kDa isoform 1; Zeta chain associated protein kinase 70 kDa isoform 2; Zeta chain of T cell receptor associated protein kinase 70; Zeta chain TCR associated protein kinase 70kD; Zeta chain TCR associated protein kinase 70 kDa	IHC-P, WB, ICC/IF, ELISA	Human, Mouse
	ZAP70 Antibody (YA5523) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZAP70.