1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Senazodan hydrochloride

Senazodan hydrochloride  (Synonyms: MCI 154 hydrochloride)

Cat. No.: HY-101693A Purity: 99.74%
COA Handling Instructions

Senazodan (MCI 154) (hydrochloride), as a Ca2+ sensitiser, shows inhibition effect on PDE III.

For research use only. We do not sell to patients.

Senazodan hydrochloride Chemical Structure

Senazodan hydrochloride Chemical Structure

CAS No. : 98326-33-1

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Description

Senazodan (MCI 154) (hydrochloride), as a Ca2+ sensitiser, shows inhibition effect on PDE III[1][2].

IC50 & Target

PDE III[1]

In Vitro

Senazodan (hydrochloride) seems to affect directly the actin-myosin crossbridge kinetics, and increases myosin ATPase activity[1]. Senazodan (hydrochloride) produces a concentration-dependent increase in tension development. Senazodan (hydrochloride) enhances Ca2+ binding to myofilaments and to purified cardiac troponin C. Senazodan (hydrochloride) also enhances contractility in guinea-pig papillary muscles by inhibiting PDE III[2].Senazodan (0.1 nM~0.1 mM) (hydrochloride) shows that the contractile response of superior mesenteric arterie (SMA) to norepinephrine (NE) after hemorrhagic shock is significantly decreased as compared with the normal control group. Senazodan (0.01 mM) (hydrochloride) pretreatment prevents the effects of Ang II, and the concentration-response curve of Ca2+ is shifted to the right as compared with Ang II-alone group[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Senazodan (0.1~2.0 mg/kg; left femoral vein catheterization infusion) (hydrochloride) decreases the pressor effect of norepinephrine (NE)[3].
Senazodan (0.1 mg/kg; i.v.) (hydrochloride) makes LVSP, IP, MC, and Lo all increased significantly, while heart rate is not obviously changed and left ventricular end-diastolic pressure (LVEDP) is reduced remarkably[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (200~250 g)[3]
Dosage: 0.1~2.0 mg/kg
Administration: Left femoral vein catheterization infusion
Result: Decreased the pressor effect of norepinephrine (NE).
Animal Model: Rabbits[4]
Dosage: 0.1 mg/kg
Administration: I.v.
Result: LVSP, IP, MC, and Lo all were increased significantly while heart rate was not obviously changed and left ventricular end-diastolic pressure (LVEDP) was reduced remarkably.
Molecular Weight

302.76

Formula

C15H15ClN4O

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

[H]Cl.O=C1CCC(C2=CC=C(NC3=CC=NC=C3)C=C2)=NN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 67.5 mg/mL (222.95 mM; Need ultrasonic)

H2O : 25 mg/mL (82.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3029 mL 16.5147 mL 33.0295 mL
5 mM 0.6606 mL 3.3029 mL 6.6059 mL
10 mM 0.3303 mL 1.6515 mL 3.3029 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.26 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.74%

References
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Senazodan hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Senazodan hydrochloride
Cat. No.:
HY-101693A
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