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Cat. No.: HY-182323

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SGK1-IN-7

SGK1-IN-7 is a blood-brain barrier-permeable SGK1 inhibitor with an IC₅₀ of 0.72 μM. SGK1-IN-7 reduces the phosphorylation level of TAU protein at the Ser396 and Ser214 epitopes. SGK1-IN-7 antagonizes the toxicity induced by Okadaic acid (HY-N6785). SGK1-IN-7 can be used in the research of Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 3109982-58-0
Formula: C₁₉H₁₄Cl₂N₄O
Molecular Weight:385.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SGK1-IN-7 Chemical Structure

CAS No.: 3109982-58-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All SGK Isoforms :

In Vitro

SGK1-IN-7 (Compound 102) (6.25-50 μM; 30 min) is non-mutagenic and has a low cardiac safety risk, with no significant inhibition of hERG or Nav1.5 channels and moderate Cav1.2 inhibition (IC₅₀ = 12.1 μM)^[1].
SGK1-IN-7 (5 μM; 24 h) exerts significant neuroprotective effects in Okadaic acid-treated SH-SY5Y human neuroblastoma cells at 5 μM^[1].
SGK1-IN-7 (5 μM; 24 h) significantly reduces phosphorylation of tau at Ser396 and Ser214 sites in SH-SY5Y human neuroblastoma cells at 5 μM without altering total tau levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SH-SY5Y human neuroblastoma cells
Concentration:

5 μM
Incubation Time:

24 h (OA pre-treatment)
Result:

Significantly restored cell viability in OA-treated SH-SY5Y cells, showing a statistically significant neuroprotective effect compared to OA-only treatment.

Parmacokinetics

Species	Dose	Route	T_max (Plasma)	AUC_last	T_1/2	Bioavailability
Mice^[1]	2.5 mg/kg	i.v.	/	954.87 ng·h/mL	0.93 h	/
Mice^[1]	5 mg/kg	i.p.	0.25 h	793.15	1.24 h	/
Mice^[1]	10 mg/kg	p.o.	0.50 h	806.97 ng·h/mL	1.83 h	21 %

In Vivo

SGK1-IN-7 (Compound 102) (2.5-10 mg/kg; i.v., i.p., p.o.; single dose) exhibits dose-dependent plasma and brain exposure in male BALB/c mice, with brain-plasma ratios (brain-Kp) of 0.49, 0.18, and 0.25 following i.v., i.p., and p.o. single-dose administration, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3109982-58-0
Molecular Weight 385.25
Formula C₁₉H₁₄Cl₂N₄O
SMILES

O=C(C1=CN(C)C=C1C2=CC=C(Cl)C(Cl)=C2)NC3=CC4=C(NN=C4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Madruga E, et al. Brain Permeable SGK1 Inhibitors: A Promising Therapeutic Strategy for Neurodegenerative Diseases. J Med Chem. 2026;69(6):6790-6815. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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SGK1-IN-7

All SGK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SGK1-IN-7 Related Classifications

HY-182323 Related Classifications