3109982-58-0
3109982-58-0
Chemical Structure
SGK1-IN-7
- CAS No.: 3109982-58-0
- Formula:C19H14Cl2N4O
- Molecular Weight:385.25
InChIKey: XYXIXBHXJZWDHB-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C)C=C1C2=CC=C(Cl)C(Cl)=C2)NC3=CC4=C(NN=C4)C=C3
Biological Activity: SGK1-IN-7 is a blood-brain barrier-permeable SGK1 inhibitor with an IC50 of 0.72 μM. SGK1-IN-7 reduces the phosphorylation level of TAU protein at the Ser396 and Ser214 epitopes. SGK1-IN-7 antagonizes the toxicity induced by Okadaic acid (HY-N6785). SGK1-IN-7 can be used in the research of Alzheimer's disease[1].
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SGK1-IN-7 | SGK1-IN-7 is a blood-brain barrier-permeable SGK1 inhibitor with an IC50 of 0.72 μM. SGK1-IN-7 reduces the phosphorylation level of TAU protein at the Ser396 and Ser214 epitopes. SGK1-IN-7 antagonizes the toxicity induced by Okadaic acid (HY-N6785). SGK1-IN-7 can be used in the research of Alzheimer's disease. | |||||||||||||||||||||
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References
Keywords
