2. TGF-beta/Smad
  3. TGF-β Receptor
  4. TGFβ1-IN-5

TGFβ1-IN-5 is a TGF-β1 inhibitor with blood-brain barrier permeability. TGFβ1-IN-5 reduces extracellular TGF-β1 levels in glioblastoma cells. TGFβ1-IN-5 exerts antiproliferative, antimigratory and clonogenic inhibitory effects in glioblastoma cells while maintaining the viability of non-cancerous cells. TGFβ1-IN-5 can be used for the research of glioblastoma.

For research use only. We do not sell to patients.

TGFβ1-IN-5

TGFβ1-IN-5 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

TGFβ1-IN-5 Related Antibodies

Top Publications Citing Use of Products

View All TGF-β Receptor Isoform Specific Products:

View All Isoforms
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B BMP

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TGFβ1-IN-5 is a TGF-β1 inhibitor with blood-brain barrier permeability. TGFβ1-IN-5 reduces extracellular TGF-β1 levels in glioblastoma cells. TGFβ1-IN-5 exerts antiproliferative, antimigratory and clonogenic inhibitory effects in glioblastoma cells while maintaining the viability of non-cancerous cells. TGFβ1-IN-5 can be used for the research of glioblastoma[1].

In Vitro

TGFβ1-IN-5 (Compound 3e) (0-100 μM; 24 h) exhibits moderately potent selective antiproliferative activity against U87 cells (IC50 = 41.09 μM), while showing no significant inhibitory effect on non-cancerous cells BEAS-2B and HUVEC[1].
TGFβ1-IN-5 (41 μM; 24 h) reduces extracellular TGF-β1 levels in U87 glioblastoma cells[1].
TGFβ1-IN-5 (20-80 μM; 24 h) reduces the number of U87 glioblastoma cells in a concentration-dependent manner, but exerts no significant effect on the number of non-cancerous HUVEC cells[1].
TGFβ1-IN-5 (41 μM; 72 h) significantly inhibits the migration of U87 glioblastoma cells in a time-dependent manner[1].
TGFβ1-IN-5 (41 μM; 5 days) inhibits the long-term clonogenic potential of U87 glioblastoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TGFβ1-IN-5 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: U87 cells, BEAS-2B cells, HUVEC cells
Concentration: 0,
1.5, 3.1, 6.2, 12.5, 25, 50, and 100 μM
Incubation Time: 24 h
Result: Showed moderate anti-proliferative activity in U87 cells with an IC50 of 41.09 μM.
Maintained high viability in non-cancerous cells, with IC50 values ≥96.60 μM in BEAS-2B and HUVEC cells.
Increased cell number in HUVEC and BEAS-2B cells at concentrations ≤3.125 μM.
Increased cell number in U87 cells at concentrations ≤12.5 μM.

ELISA Assay[1]

Cell Line: human glioblastoma U87 cells
Concentration: 41 μM
Incubation Time: 24 h
Result: Caused a 5.5% decrease in extracellular TGF-β1 levels (88.90 pg/mL) compared to untreated control cells (94.11 pg/mL).

Cell Migration Assay [1]

Cell Line: human glioblastoma U87 cells
Concentration: 41 μM
Incubation Time: 72 h
Result: Significantly delayed wound closure compared to control cells at all time points.
Molecular Weight

553.45

Formula

C31H25BrN2O3
SMILES

O=C(C1=CC=CC=C1)/C=C/C2=CC=C(N3C=[N+](CC4=CC=C(C(OC)=O)C=C4)C5=CC=CC=C35)C=C2.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TGFβ1-IN-5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGFβ1-IN-5TGF-β ReceptorTransforming growth factor beta receptorsCYP3A4TGF-β1HUVECTyr282LY2109761BEAS-2BHis283glioblastoma cellsU87 glioblastoma cellsTGF-β1 receptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TGFβ1-IN-5
Cat. No.:
HY-183258
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.