TGFβ1-IN-5
TGFβ1-IN-5 is a TGF-β1 inhibitor with blood-brain barrier permeability. TGFβ1-IN-5 reduces extracellular TGF-β1 levels in glioblastoma cells. TGFβ1-IN-5 exerts antiproliferative, antimigratory and clonogenic inhibitory effects in glioblastoma cells while maintaining the viability of non-cancerous cells. TGFβ1-IN-5 can be used for the research of glioblastoma.
For research use only. We do not sell to patients.
- Formula: C31H25BrN2O3
- Molecular Weight:553.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
TGFβ1-IN-5 (Compound 3e) (0-100 μM; 24 h) exhibits moderately potent selective antiproliferative activity against U87 cells (IC50 = 41.09 μM), while showing no significant inhibitory effect on non-cancerous cells BEAS-2B and HUVEC[1].
TGFβ1-IN-5 (41 μM; 24 h) reduces extracellular TGF-β1 levels in U87 glioblastoma cells[1].
TGFβ1-IN-5 (20-80 μM; 24 h) reduces the number of U87 glioblastoma cells in a concentration-dependent manner, but exerts no significant effect on the number of non-cancerous HUVEC cells[1].
TGFβ1-IN-5 (41 μM; 72 h) significantly inhibits the migration of U87 glioblastoma cells in a time-dependent manner[1].
TGFβ1-IN-5 (41 μM; 5 days) inhibits the long-term clonogenic potential of U87 glioblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:U87 cells, BEAS-2B cells, HUVEC cells
-
Concentration:0,
1.5, 3.1, 6.2, 12.5, 25, 50, and 100 μM -
Incubation Time:24 h
-
Result:Showed moderate anti-proliferative activity in U87 cells with an IC50 of 41.09 μM.
Maintained high viability in non-cancerous cells, with IC50 values ≥96.60 μM in BEAS-2B and HUVEC cells.
Increased cell number in HUVEC and BEAS-2B cells at concentrations ≤3.125 μM.
Increased cell number in U87 cells at concentrations ≤12.5 μM.
-
Cell Line:human glioblastoma U87 cells
-
Concentration:41 μM
-
Incubation Time:24 h
-
Result:Caused a 5.5% decrease in extracellular TGF-β1 levels (88.90 pg/mL) compared to untreated control cells (94.11 pg/mL).
-
Cell Line:human glioblastoma U87 cells
-
Concentration:41 μM
-
Incubation Time:72 h
-
Result:Significantly delayed wound closure compared to control cells at all time points.
Chemical Information
-
Molecular Weight 553.45
-
Formula C31H25BrN2O3
-
SMILES
O=C(C1=CC=CC=C1)/C=C/C2=CC=C(N3C=[N+](CC4=CC=C(C(OC)=O)C=C4)C5=CC=CC=C35)C=C2.[Br-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz