1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. TNO155

TNO155 

Cat. No.: HY-136173 Purity: 99.41%
Handling Instructions

TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors.

For research use only. We do not sell to patients.

TNO155 Chemical Structure

TNO155 Chemical Structure

CAS No. : 1801765-04-7

Size Price Stock Quantity
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].

IC50 & Target

IC50: 0.011 µM (SHP2)[1]

In Vitro

TNO155 shows an IC50 of 0.008 µM in KYSE520 pERK assay and shows an IC50 of 0.100 µM in KYSE520 5-day cell proliferation assay. The off-target IC50 values are 18 µM, 6.9 µM, and 11 µM for Cav1.2, VMAT, and SST3, respectively[1].

In Vivo

The oral bioavailability in mouse, rat and money are 78%, 86%, and 60%, respectively[1].

Molecular Weight

421.95

Formula

C₁₈H₂₄ClN₇OS

CAS No.

1801765-04-7

SMILES

N[[email protected]@H]1[[email protected]](C)OCC12CCN(C3=NC(N)=C(SC4=C(Cl)C(N)=NC=C4)N=C3)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (592.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3699 mL 11.8497 mL 23.6995 mL
5 mM 0.4740 mL 2.3699 mL 4.7399 mL
10 mM 0.2370 mL 1.1850 mL 2.3699 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TNO155TNO 155TNO-155PhosphataseSHP2RTK-dependentmalignancyAberrantactivationBCSallostericEGFR-mutantNSCLCHNSCCCRCInhibitorinhibitorinhibit

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TNO155
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HY-136173
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