1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. TNO155

TNO155 

Cat. No.: HY-136173
Handling Instructions

TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors.

For research use only. We do not sell to patients.

TNO155 Chemical Structure

TNO155 Chemical Structure

CAS No. : 1801765-04-7

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Description

TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].

IC50 & Target

IC50: 0.011 µM (SHP2)[1]

In Vitro

TNO155 shows an IC50 of 0.008 µM in KYSE520 pERK assay and shows an IC50 of 0.100 µM in KYSE520 5-day cell proliferation assay. The off-target IC50 values are 18 µM, 6.9 µM, and 11 µM for Cav1.2, VMAT, and SST3, respectively[1].

In Vivo

The oral bioavailability in mouse, rat and money are 78%, 86%, and 60%, respectively[1].

Molecular Weight

421.95

Formula

C₁₈H₂₄ClN₇OS

CAS No.

1801765-04-7

SMILES

N[[email protected]@H]1[[email protected]](C)OCC12CCN(C3=NC(N)=C(SC4=C(Cl)C(N)=NC=C4)N=C3)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TNO155TNO 155TNO-155PhosphataseSHP2RTK-dependentmalignancyAberrantactivationBCSallostericEGFR-mutantNSCLCHNSCCCRCInhibitorinhibitorinhibit

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