1. Protein Tyrosine Kinase/RTK
  2. PDGFR
    VEGFR
    c-Kit
  3. Toceranib-d8

Toceranib-d8 

Cat. No.: HY-10330S
Handling Instructions

Toceranib-d8 (SU11654-d8) is the deuterium labeled Toceranib. Toceranib (SU11654) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib (SU11654) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors.

For research use only. We do not sell to patients.

Toceranib-d8 Chemical Structure

Toceranib-d8 Chemical Structure

CAS No. : 1795134-78-9

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Description

Toceranib-d8 (SU11654-d8) is the deuterium labeled Toceranib. Toceranib (SU11654) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib (SU11654) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

404.51

Formula

C₂₂H₁₇D₈FN₄O₂

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Toceranib-d8
Cat. No.:
HY-10330S
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