1. GPCR/G Protein
  2. Adenosine Receptor
  3. Tonapofylline

Tonapofylline (Synonyms: BG 9928)

Cat. No.: HY-14873 Purity: >98.0%
Handling Instructions

Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.

For research use only. We do not sell to patients.

Tonapofylline Chemical Structure

Tonapofylline Chemical Structure

CAS No. : 340021-17-2

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5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure[1][2].

IC50 & Target

Ki: 7.4 nM (Human adenosine A1 receptor)[1]

In Vivo

Tonapofylline (BG 9928) (1 mg/kg; p.o., b.i.d, days 0-6) produces sustained reductions in post-Cisplatin serum creatinine and blood urea nitrogen levels, improves body weight recovery and significant attenuation of Cisplatin-induced (5.5 mg/kg) kidney pathology scores[3].

Animal Model: Female viral antigen-free Sprague-Dawley rats[3]
Dosage: 1 mg/kg
Administration: Oral administration; twice a day, days 0-6
Result: Produced sustained reductions in post-Cisplatin serum creatinine and blood urea nitrogen levels, improved body weight recovery and significant attenuation of Cisplatin-induced (5.5 mg/kg) kidney pathology scores.
Clinical Trial
Molecular Weight

416.51

Formula

C₂₂H₃₂N₄O₄

CAS No.

340021-17-2

SMILES

O=C(O)CCC1(CC2)CCC2(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)CC1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Tonapofylline
Cat. No.:
HY-14873
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