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  4. Trypanothione synthetase-IN-1

Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S.

For research use only. We do not sell to patients.

Trypanothione synthetase-IN-1 Chemical Structure

Trypanothione synthetase-IN-1 Chemical Structure

CAS No. : 2355349-41-4

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Trypanothione synthetase-IN-1 Related Antibodies

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Description

Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S[1].

IC50 & Target

Leishmania

 

In Vitro

Trypanothione synthetase-IN-1 (Compound 1) (0-75 μM; 24 or 72 h) shows leishmanicidal activity with cytotoxicity[1].
Trypanothione synthetase-IN-1 competes with ATP and the polyamine substrate for binding to LiTryS[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trypanothione synthetase-IN-1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: L. infantum, HepG2
Concentration: 0-75 μM
Incubation Time: 24 h (L. infantum axenic amastigotes) or 72 h
Result: Showed leishmanicidal activity with EC50s of 21.5 ± 2.4 μM and 13.5 ± 0.9 μM against axenic amastigotes and intracellular amastigotes, respectively. Showed cytotoxicity with a CC50 of 15.9 ± 0.4 μM against HepG2 cells.
Molecular Weight

785.83

Formula

C40H38F3N7O5S
CAS No.
SMILES

[NH3+]CCCCC1=CN(C2=CC(OCCN3CCNC3=O)=C(C=C2)C4=NC(C5=CC=C(C=C5)OC6=CC=CC=C6)=C(C7=CC=CC=C7)S4)N=N1.O=C([O-])C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Trypanothione synthetase-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trypanothione synthetase-IN-12355349-41-4ParasiteleishmanicidalLeishmania infantumtrypanothione synthetaseTrySInhibitorinhibitorinhibit

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Trypanothione synthetase-IN-1
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