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Trypanothione synthetase-IN-1 

Cat. No.: HY-151148
Handling Instructions

Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S.

For research use only. We do not sell to patients.

Trypanothione synthetase-IN-1 Chemical Structure

Trypanothione synthetase-IN-1 Chemical Structure

CAS No. : 2355349-41-4

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Description

Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S[1].

IC50 & Target

IC50: 14.8 μM (LiTryS, triamine spermidine as polyamine S), 16.2 μM (LiTryS, glutathionylspermidine as polyamine S)[1]

In Vitro

Trypanothione synthetase-IN-1 (Compound 1) (0-75 μM; 24 or 72 h) shows leishmanicidal activity with cytotoxicity[1].
Trypanothione synthetase-IN-1 competes with ATP and the polyamine substrate for binding to LiTryS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: L. infantum, HepG2
Concentration: 0-75 μM
Incubation Time: 24 h (L. infantum axenic amastigotes) or 72 h
Result: Showed leishmanicidal activity with EC50s of 21.5 ± 2.4 μM and 13.5 ± 0.9 μM against axenic amastigotes and intracellular amastigotes, respectively. Showed cytotoxicity with a CC50 of 15.9 ± 0.4 μM against HepG2 cells.
Molecular Weight

785.83

Formula

C40H38F3N7O5S

CAS No.
SMILES

[NH3+]CCCCC1=CN(C2=CC(OCCN3CCNC3=O)=C(C=C2)C4=NC(C5=CC=C(C=C5)OC6=CC=CC=C6)=C(C7=CC=CC=C7)S4)N=N1.O=C([O-])C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Trypanothione synthetase-IN-1
Cat. No.:
HY-151148
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