Trypanothione synthetase-IN-1
Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S.
For research use only. We do not sell to patients.
- CAS No.: 2355349-41-4
- Formula: C40H38F3N7O5S
- Molecular Weight:785.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Leishmania |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
≥75 μM
Compound: 19c
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Cytotoxicity against human HepG2 cells incubated for 24 hrs by crystal violet staining based assay
Cytotoxicity against human HepG2 cells incubated for 24 hrs by crystal violet staining based assay
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[PMID: 33945281] |
| HepG2 | CC50 |
15.9 μM
Compound: 1
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Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation measured after 72 hrs by crystal violet staining based analysis
Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation measured after 72 hrs by crystal violet staining based analysis
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[PMID: 36075146] |
| THP-1 | EC50 |
>75 μM
Compound: 19c
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Cytotoxicity against human THP-1 cells by LDH assay
Cytotoxicity against human THP-1 cells by LDH assay
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[PMID: 33945281] |
Trypanothione synthetase-IN-1 (Compound 1) (0-75 μM; 24 or 72 h) shows leishmanicidal activity with cytotoxicity[1].
Trypanothione synthetase-IN-1 competes with ATP and the polyamine substrate for binding to LiTryS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L. infantum, HepG2
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Concentration:0-75 μM
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Incubation Time:24 h (L. infantum axenic amastigotes) or 72 h
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Result:Showed leishmanicidal activity with EC50s of 21.5 ± 2.4 μM and 13.5 ± 0.9 μM against axenic amastigotes and intracellular amastigotes, respectively. Showed cytotoxicity with a CC50 of 15.9 ± 0.4 μM against HepG2 cells.
Chemical Information
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CAS No. 2355349-41-4
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Molecular Weight 785.83
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Formula C40H38F3N7O5S
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SMILES
[NH3+]CCCCC1=CN(C2=CC(OCCN3CCNC3=O)=C(C=C2)C4=NC(C5=CC=C(C=C5)OC6=CC=CC=C6)=C(C7=CC=CC=C7)S4)N=N1.O=C([O-])C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trypanothione synthetase-IN-1 Related Classifications
HY-151148 Related Classifications
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