Cat. No.: HY-Y1667

2,6-Dibromophenol

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca²⁺ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC₅₀ of 2.78 mg/L for Daphnia magna and a 96 h EC₅₀ of 9.90 mg/L for algae (Scenedesmus quadricauda).

For research use only. We do not sell to patients.

Purity: 99.76%
CAS No.: 608-33-3
Formula: C₆H₄Br₂O
Molecular Weight:251.91

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

2,6-Dibromophenol Chemical Structure

CAS No.: 608-33-3

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Calcium Channel Isoforms :

All Parasite Isoforms :

In Vitro

In the calcium signaling experiment of PC12 cells, 2,6-Dibromophenol (30 μM, 300 μM) has no significant effect on the increase of intracellular Ca²⁺ induced by K⁺^[1].
In the growth inhibition experiment of Scenedesmus quadricaudaa, ??2,6-Dibromophenol (1.0-20.0 mg/L; 96 h) inhibits cell growth in a concentration-dependent manner, with an EC₅₀ of 9.90 mg/L for 96 h^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

Scenedesmus quadricauda

Concentration:

1.0 mg/L, 2.0 mg/L, 5.0 mg/L, 10.0 mg/L, 15.0 mg/L, 20.0 mg/L

Incubation Time:

96 h

Result:

Significantly inhibited the growth of Scenedesmus quadricauda in a concentration-dependent manner.

Chemical Information

CAS No. 608-33-3

Appearance Solid

Molecular Weight 251.91

Formula C₆H₄Br₂O

Color White to off-white

SMILES

OC1=C(Br)C=CC=C1Br

Structure Classification

Phenols

Monophenols

Initial Source

Endogenous metabolite

Marine natural products

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Publications (1)

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Journal Impact Factor

Most Recent

Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (396.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.9697 mL

19.8484 mL

39.6967 mL

5 mM

0.7939 mL

3.9697 mL

7.9393 mL

10 mM

0.3970 mL

1.9848 mL

3.9697 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

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Molecular Weight Molecular Weight

Dilution Calculator

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:

To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO    40% PEG300    5% Tween-80    45% Saline
Solubility: ≥ 2.5 mg/mL (9.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

Protocol 2

Add each solvent one by one: 10% DMSO    90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

Protocol 3

Add each solvent one by one: 10% DMSO    90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg

Animal Weight (Per Animal) Animal Weight (Per Animal)
g

Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL

Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

%
+

+
%
Tween-80 + +

%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact
MedChemExpress (MCE) .

Tel: 609-228-6898
E-mail: [email protected]
Technical Support: [email protected]

Method for preparing in vivo working solution for animal experiments:
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Saline .

Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)

SDS (393 KB)

English - EN (393 KB)

Français - FR (393 KB)

Deutsch - DE (393 KB)

Norwegian - NO (393 KB)

Español - ES (393 KB)

Swedish - SV (393 KB)

Italian - IT (393 KB)

Korean - KR (393 KB)

Portuguese - PT (393 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. Hassenklöver T, et al. Bromophenols, both present in marine organisms and in industrial flame retardants, disturb cellular Ca2+ signaling in neuroendocrine cells (PC12). Aquat Toxicol. 2006 Jan 5;76(1):37-45. [Content Brief]

[2]. Li B, et al. Acute Toxicities of Bromophenols to Alga and Daphina: Comparative Species Sensitivity Distribution Between Standard and Dietary Supplementation Tests. J Toxicol. 2025 May 11;2025:3399746. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 3.9697 mL 19.8484 mL 39.6967 mL 99.2418 mL

5 mM 0.7939 mL 3.9697 mL 7.9393 mL 19.8484 mL

10 mM 0.3970 mL 1.9848 mL 3.9697 mL 9.9242 mL

15 mM 0.2646 mL 1.3232 mL 2.6464 mL 6.6161 mL

20 mM 0.1985 mL 0.9924 mL 1.9848 mL 4.9621 mL

25 mM 0.1588 mL 0.7939 mL 1.5879 mL 3.9697 mL

30 mM 0.1323 mL 0.6616 mL 1.3232 mL 3.3081 mL

40 mM 0.0992 mL 0.4962 mL 0.9924 mL 2.4810 mL

50 mM 0.0794 mL 0.3970 mL 0.7939 mL 1.9848 mL

60 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.6540 mL

80 mM 0.0496 mL 0.2481 mL 0.4962 mL 1.2405 mL

100 mM 0.0397 mL 0.1985 mL 0.3970 mL 0.9924 mL

2,6-Dibromophenol Related Classifications

HY-Y1667 Related Classifications

Membrane Transporter/Ion Channel Anti-infection Neuronal Signaling

Calcium Channel Parasite Fungal

Disease Areas

Infection Blood or Cardio-cerebrovascular Disease Neurological, Eye or Ear Disease Metabolic or Endocrine Disease

Cardiovascular Disease Fungal Infection Parasitic Infection

Hypertension

Natural Products

Disease Research Fields Phenols Endogenous metabolite Marine natural products

Metabolic Disease Monophenols

Reference Standards

Natural Product Standards

Phenols

Metabolic Disease

Powered by Bioz See more details on Bioz

Keywords

2,6-Dibromophenol
608-33-3
Calcium Channel
Parasite
Fungal
Inhibitor
inhibitor
inhibit

Your Recently Viewed Products

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.9697 mL	19.8484 mL	39.6967 mL	99.2418 mL
5 mM	0.7939 mL	3.9697 mL	7.9393 mL	19.8484 mL
10 mM	0.3970 mL	1.9848 mL	3.9697 mL	9.9242 mL
15 mM	0.2646 mL	1.3232 mL	2.6464 mL	6.6161 mL
20 mM	0.1985 mL	0.9924 mL	1.9848 mL	4.9621 mL
25 mM	0.1588 mL	0.7939 mL	1.5879 mL	3.9697 mL
30 mM	0.1323 mL	0.6616 mL	1.3232 mL	3.3081 mL
40 mM	0.0992 mL	0.4962 mL	0.9924 mL	2.4810 mL
50 mM	0.0794 mL	0.3970 mL	0.7939 mL	1.9848 mL
60 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.6540 mL
80 mM	0.0496 mL	0.2481 mL	0.4962 mL	1.2405 mL
100 mM	0.0397 mL	0.1985 mL	0.3970 mL	0.9924 mL

2,6-Dibromophenol

1 Cited Publications

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2,6-Dibromophenol

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Publications Citing Use of MedChemExpress (MCE) 2,6-Dibromophenol

All Calcium Channel Isoforms

All Parasite Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table