TRIM37 - tripartite motif containing 37 Gene

Also Known as MUL; POB1; TEF3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4591

About TRIM37

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,967,201-59,106,880 (from NCBI)

This gene has 14 transcripts (splice variants), 206 orthologues, 80 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 19.8), brain (RPKM 14.1) and 23 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]

TRIM37 Products (11)

mRNA	Protein	Name
NM_001005207.5	NP_001005207.1	E3 ubiquitin-protein ligase TRIM37 isoform a
NM_001320987.3	NP_001307916.1	E3 ubiquitin-protein ligase TRIM37 isoform b
NM_001320988.3	NP_001307917.1	E3 ubiquitin-protein ligase TRIM37 isoform c
NM_001320989.3	NP_001307918.1	E3 ubiquitin-protein ligase TRIM37 isoform c
NM_001320990.3	NP_001307919.1	E3 ubiquitin-protein ligase TRIM37 isoform d
NM_001353082.2	NP_001340011.1	E3 ubiquitin-protein ligase TRIM37 isoform e
NM_001353083.2	NP_001340012.1	E3 ubiquitin-protein ligase TRIM37 isoform f
NM_001353084.2	NP_001340013.1	E3 ubiquitin-protein ligase TRIM37 isoform g
NM_001353085.2	NP_001340014.1	E3 ubiquitin-protein ligase TRIM37 isoform h
NM_001353086.2	NP_001340015.1	E3 ubiquitin-protein ligase TRIM37 isoform i
NM_015294.6	NP_056109.1	E3 ubiquitin-protein ligase TRIM37 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone H2AK119 ubiquitin ligase activity	IDA IDA: Inferred from direct assay	25470042	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11279055	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11279055	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA
enables tumor necrosis factor receptor binding	IPI IPI: Inferred from physical interaction	11279055	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	28724525	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11279055	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	15885686	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in aggresome assembly	IDA IDA: Inferred from direct assay	15885686	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	11279055	GOA
involved in negative regulation of centriole replication	IMP IMP: Inferred from mutant phenotype	23769972	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	25470042	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25470042	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	15885686	GOA
acts upstream of protein import into peroxisome matrix	IDA IDA: Inferred from direct assay	28724525	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	28724525	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	28724525	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	25470042	GOA
located in aggresome	IDA IDA: Inferred from direct assay	15885686	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23769972	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11279055	GOA
is active in peroxisomal membrane	IDA IDA: Inferred from direct assay	28724525	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	11938494	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM37 Protein Structure

zf-B_box

MATH

0
200
400
600
800
964 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIM37	RING-B-box-coiled-coil protein

TRIM37 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM37	O94972	a8k932_human	Homo sapiens	A8K932	Validated Y2H	25416956
Intra	TRIM37	O94972	a8k932_human	Homo sapiens	A8K932	Y2H Array	25416956
Intra	TRIM37	O94972	FAM107A	Homo sapiens	O95990-3	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	FAM107A	Homo sapiens	O95990-3	Validated Y2H	25416956
Intra	TRIM37	O94972	FAM107A	Homo sapiens	O95990-3	Y2H Array	25416956
Intra	TRIM37	O94972	CDC20B	Homo sapiens	Q86Y33	Validated Y2H	25416956
Intra	TRIM37	O94972	DZIP1L	Homo sapiens	Q8IYY4	Validated Y2H	32296183
Intra	TRIM37	O94972	PNKP	Homo sapiens	Q96T60	Y2H Pooling	16189514
Intra	TRIM37	O94972	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	TRIM37	O94972	PNKP	Homo sapiens	Q96T60	BRET	38225382
Intra	TRIM37	O94972	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	TRIM37	O94972	CDC20B	Homo sapiens	Q86Y33-5	Validated Y2H	32296183
Intra	TRIM37	O94972	UBASH3A	Homo sapiens	P57075	Validated Y2H	25416956
Intra	TRIM37	O94972	UBASH3A	Homo sapiens	P57075	Y2H Array	25416956
Intra	TRIM37	O94972	UBASH3A	Homo sapiens	P57075	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	TRIM37	O94972	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	TRIM37	O94972	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	MCRS1	Homo sapiens	Q96EZ8	Y2H Pooling	16189514
Intra	TRIM37	O94972	DDX6	Homo sapiens	P26196	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	DDX6	Homo sapiens	P26196	Y2H Array	25416956
Intra	TRIM37	O94972	BYSL	Homo sapiens	Q13895	Validated Y2H	25416956
Intra	TRIM37	O94972	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	TRIM37	O94972	COPB1	Homo sapiens	P53618	Validated Y2H	32296183
Intra	TRIM37	O94972	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	32296183
Intra	TRIM37	O94972	CWF19L2	Homo sapiens	Q2TBE0	Validated Y2H	32296183
Intra	TRIM37	O94972	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	TRIM37	O94972	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	TRIM37	O94972	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
Intra	TRIM37	O94972	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	TRIM37	O94972	ZNF417	Homo sapiens	Q8TAU3	Y2H Pooling	16189514
Intra	TRIM37	O94972	RASD1	Homo sapiens	Q9Y272	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	RASD1	Homo sapiens	Q9Y272	Validated Y2H	25416956
Intra	TRIM37	O94972	RASD1	Homo sapiens	Q9Y272	Y2H Array	25416956
Intra	TRIM37	O94972	PRC1	Homo sapiens	O43663	Y2H Pooling	16189514
Intra	TRIM37	O94972	ELOA	Homo sapiens	Q14241	Validated Y2H	32296183
Intra	TRIM37	O94972	FAM50B	Homo sapiens	Q9Y247	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	TRIM37	O94972	SYTL4	Homo sapiens	Q96C24	Validated Y2H	32296183
Intra	TRIM37	O94972	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

TRIM37 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89595	TRIM37 Antibody (YA8939)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Mulibrey Nanism	MUL Muscle-Liver-Brain-Eye Nanism Pericardial Constriction And Growth Failure Perheentupa Syndrome Mulibrey Growth Disorder Mulibrey Nanism Syndrome Pericardial Constriction With Growth Failure Nanism Mulibrey
Acid-Labile Subunit Deficiency	Short Stature Due To Primary Acid-Labile Subunit Deficiency ACLSD Acid-Labile Subunit, Deficiency Of Decreased Levels Of Acid Labile Subunit Growth Disorders
Peroxisomal Disease	Peroxisomal Disorder Peroxisomal Disorders Peroxisomal Defects
Constrictive Pericarditis	Pericarditis, Constrictive Pericarditis Constrictive Pericarditis Calculosa Hutinel-Pick Syndrome Chronic Tamponade Chronic Pericardial Constriction Pick Syndrome Of Heart Pick Disease Of Heart Concretio Cordis Calcareous Pericarditis
Childhood Osteosarcoma	Pediatric Osteosarcoma
Three M Syndrome 1	3-M Syndrome Yakut Short Stature Syndrome 3m Syndrome Le Merrer Syndrome Dolichospondylic Dysplasia Gloomy Face Syndrome Three M Syndrome 3M1 3m Syndrome 1 Miller-Mckusick-Malvaux Syndrome 3-Msbn Three-M Slender-Boned Nanism Miller-Mckusick-Malvaux-Syndrome 3-M Syndrome 1 3m Syndrome-1 3m Syndrome, Type 1 Dwarfism Dwarfism Tall Vertebrae
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-149324	SP27		98.87%	Phase 4
HY-172737	RP-1664	Inhibitor	98.77%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15041	TRIM37 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIM37	RGD	RGD:1308349
Bos taurus	TRIM37	VGNC	VGNC:36332
Mus musculus	TRIM37	MGD	MGI:2153072
Macaca mulatta	TRIM37	VGNC	VGNC:79966
Felis catus	TRIM37	VGNC	VGNC:68360
Canis familiaris	TRIM37	VGNC	VGNC:47818
Others	TRIM37	NCBI