1. Apoptosis
  2. Caspase
  3. ZYZ-488

ZYZ-488 

Cat. No.: HY-100472 Purity: 99.80%
Handling Instructions

ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3.

For research use only. We do not sell to patients.

ZYZ-488 Chemical Structure

ZYZ-488 Chemical Structure

CAS No. : 1470302-79-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3[1].

IC50 & Target

Apoptotic protease activating factor-1[1]

In Vitro

ZYZ-488 decreases apoptosis in hypoxic H9c2 cells. ZYZ-488 inhibits hypoxia induced Apaf-1-mediated activation of procaspase-9 and procaspase-3[1].
ZYZ-488 decreases myocardial enzyme release, inhibits cardiomyocyte apoptosis, and suppresses the activation of the downstream cascade of caspases[2].

In Vivo

ZYZ-488 (33.9-67.8 mg/kg; intramuscularly; for 3 days) protected against myocardial apoptosis[2].

Animal Model: Male C57BL/6 mice (8-10 weeks old)[2]
Dosage: myocardial infarction + ZYZ-488 (33.9 mg/kg); myocardial infraction + ZYZ-488 (67.8 mg/kg);
Administration: Intramuscularly; for 3 days
Result: Inhibited Apaf-1-mediated activation of procaspase-9 and procaspase-3.
Molecular Weight

487.46

Formula

C₂₀H₂₉N₃O₁₁

CAS No.

1470302-79-4

SMILES

O=C(OCCCCNC(N)=N)C(C=C1OC)=CC(OC)=C1O[[email protected]]2[[email protected]](O)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](C(O)=O)O2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (410.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0515 mL 10.2573 mL 20.5145 mL
5 mM 0.4103 mL 2.0515 mL 4.1029 mL
10 mM 0.2051 mL 1.0257 mL 2.0515 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (10.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (10.26 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (10.26 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.80%

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Keywords:

ZYZ-488ZYZ488ZYZ 488Caspasehypoxiaprocaspase-9procaspase-3myocardialcardiomyocyteInhibitorinhibitorinhibit

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Product Name:
ZYZ-488
Cat. No.:
HY-100472
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